![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RABL2B |
Gene summary for RABL2B |
![]() |
Gene information | Species | Human | Gene symbol | RABL2B | Gene ID | 11158 |
Gene name | RAB, member of RAS oncogene family like 2B | |
Gene Alias | RABL2B | |
Cytomap | 22q13.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9UNT1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11158 | RABL2B | P24T-E | Human | Esophagus | ESCC | 4.28e-14 | 3.31e-01 | 0.1287 |
11158 | RABL2B | P26T-E | Human | Esophagus | ESCC | 3.29e-16 | 3.24e-01 | 0.1276 |
11158 | RABL2B | P27T-E | Human | Esophagus | ESCC | 3.93e-09 | 1.81e-01 | 0.1055 |
11158 | RABL2B | P28T-E | Human | Esophagus | ESCC | 2.05e-17 | 3.22e-01 | 0.1149 |
11158 | RABL2B | P30T-E | Human | Esophagus | ESCC | 4.73e-17 | 6.35e-01 | 0.137 |
11158 | RABL2B | P31T-E | Human | Esophagus | ESCC | 2.63e-16 | 2.15e-01 | 0.1251 |
11158 | RABL2B | P32T-E | Human | Esophagus | ESCC | 2.29e-25 | 4.72e-01 | 0.1666 |
11158 | RABL2B | P36T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.72e-01 | 0.1187 |
11158 | RABL2B | P37T-E | Human | Esophagus | ESCC | 1.32e-11 | 2.58e-01 | 0.1371 |
11158 | RABL2B | P39T-E | Human | Esophagus | ESCC | 1.92e-06 | 1.22e-01 | 0.0894 |
11158 | RABL2B | P40T-E | Human | Esophagus | ESCC | 1.12e-07 | 2.44e-01 | 0.109 |
11158 | RABL2B | P42T-E | Human | Esophagus | ESCC | 4.37e-15 | 4.75e-01 | 0.1175 |
11158 | RABL2B | P44T-E | Human | Esophagus | ESCC | 8.49e-12 | 2.84e-01 | 0.1096 |
11158 | RABL2B | P47T-E | Human | Esophagus | ESCC | 6.25e-10 | 2.05e-01 | 0.1067 |
11158 | RABL2B | P48T-E | Human | Esophagus | ESCC | 1.15e-04 | 2.02e-01 | 0.0959 |
11158 | RABL2B | P52T-E | Human | Esophagus | ESCC | 6.70e-16 | 3.02e-01 | 0.1555 |
11158 | RABL2B | P54T-E | Human | Esophagus | ESCC | 1.94e-08 | 1.08e-01 | 0.0975 |
11158 | RABL2B | P56T-E | Human | Esophagus | ESCC | 1.09e-14 | 1.28e+00 | 0.1613 |
11158 | RABL2B | P57T-E | Human | Esophagus | ESCC | 9.25e-12 | 2.42e-01 | 0.0926 |
11158 | RABL2B | P61T-E | Human | Esophagus | ESCC | 7.85e-12 | 2.24e-01 | 0.099 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
GO:001097013 | Esophagus | ESCC | transport along microtubule | 107/8552 | 155/18723 | 3.17e-09 | 6.80e-08 | 107 |
GO:003150314 | Esophagus | ESCC | protein-containing complex localization | 139/8552 | 220/18723 | 1.14e-07 | 1.85e-06 | 139 |
GO:00991114 | Esophagus | ESCC | microtubule-based transport | 115/8552 | 190/18723 | 2.54e-05 | 2.15e-04 | 115 |
GO:003070510 | Oral cavity | OSCC | cytoskeleton-dependent intracellular transport | 113/7305 | 195/18723 | 6.03e-08 | 1.09e-06 | 113 |
GO:00315034 | Oral cavity | OSCC | protein-containing complex localization | 123/7305 | 220/18723 | 2.54e-07 | 4.00e-06 | 123 |
GO:00109706 | Oral cavity | OSCC | transport along microtubule | 88/7305 | 155/18723 | 5.35e-06 | 6.02e-05 | 88 |
GO:00991113 | Oral cavity | OSCC | microtubule-based transport | 96/7305 | 190/18723 | 7.92e-04 | 4.27e-03 | 96 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RABL2B | SNV | Missense_Mutation | c.660N>C | p.Gln220His | p.Q220H | Q9UNT1 | protein_coding | deleterious(0.05) | benign(0.192) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
RABL2B | SNV | Missense_Mutation | novel | c.34N>C | p.Asp12His | p.D12H | Q9UNT1 | protein_coding | deleterious(0) | possibly_damaging(0.849) | TCGA-C8-A278-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD |
RABL2B | SNV | Missense_Mutation | c.155N>A | p.Ser52Tyr | p.S52Y | Q9UNT1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1XU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RABL2B | SNV | Missense_Mutation | rs782241181 | c.388N>A | p.Val130Met | p.V130M | Q9UNT1 | protein_coding | deleterious(0.04) | possibly_damaging(0.757) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RABL2B | SNV | Missense_Mutation | novel | c.497N>C | p.Val166Ala | p.V166A | Q9UNT1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RABL2B | SNV | Missense_Mutation | novel | c.320N>G | p.Val107Gly | p.V107G | Q9UNT1 | protein_coding | deleterious(0.01) | benign(0.358) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RABL2B | SNV | Missense_Mutation | novel | c.401A>C | p.Lys134Thr | p.K134T | Q9UNT1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RABL2B | SNV | Missense_Mutation | novel | c.476C>T | p.Ser159Leu | p.S159L | Q9UNT1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
RABL2B | SNV | Missense_Mutation | novel | c.476N>T | p.Ser159Leu | p.S159L | Q9UNT1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
RABL2B | SNV | Missense_Mutation | c.554G>A | p.Arg185Gln | p.R185Q | Q9UNT1 | protein_coding | tolerated(0.2) | benign(0.024) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |