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Gene: R3HDM1 |
Gene summary for R3HDM1 |
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Gene information | Species | Human | Gene symbol | R3HDM1 | Gene ID | 23518 |
Gene name | R3H domain containing 1 | |
Gene Alias | R3HDM | |
Cytomap | 2q21.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q15032 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23518 | R3HDM1 | A015-C-104 | Human | Colorectum | FAP | 4.88e-33 | -5.28e-01 | -0.1899 |
23518 | R3HDM1 | A001-C-014 | Human | Colorectum | FAP | 2.28e-19 | -4.91e-01 | 0.0135 |
23518 | R3HDM1 | A002-C-016 | Human | Colorectum | FAP | 4.80e-27 | -4.62e-01 | 0.0521 |
23518 | R3HDM1 | A015-C-002 | Human | Colorectum | FAP | 5.81e-13 | -5.19e-01 | -0.0763 |
23518 | R3HDM1 | A001-C-203 | Human | Colorectum | FAP | 2.01e-19 | -3.77e-01 | -0.0481 |
23518 | R3HDM1 | A002-C-116 | Human | Colorectum | FAP | 1.34e-31 | -5.27e-01 | -0.0452 |
23518 | R3HDM1 | A014-C-008 | Human | Colorectum | FAP | 2.18e-14 | -4.63e-01 | -0.191 |
23518 | R3HDM1 | A018-E-020 | Human | Colorectum | FAP | 1.02e-21 | -5.15e-01 | -0.2034 |
23518 | R3HDM1 | F034 | Human | Colorectum | FAP | 2.05e-18 | -4.12e-01 | -0.0665 |
23518 | R3HDM1 | F072B | Human | Colorectum | FAP | 2.64e-15 | -4.99e-01 | 0.257 |
23518 | R3HDM1 | CRC-1-8810 | Human | Colorectum | CRC | 1.58e-02 | -1.48e-01 | 0.6257 |
23518 | R3HDM1 | CRC-3-11773 | Human | Colorectum | CRC | 4.76e-16 | -3.90e-01 | 0.2564 |
23518 | R3HDM1 | LZE2T | Human | Esophagus | ESCC | 2.98e-05 | 6.87e-01 | 0.082 |
23518 | R3HDM1 | LZE4T | Human | Esophagus | ESCC | 7.17e-07 | 3.40e-01 | 0.0811 |
23518 | R3HDM1 | LZE5T | Human | Esophagus | ESCC | 2.79e-03 | 2.59e-01 | 0.0514 |
23518 | R3HDM1 | LZE7T | Human | Esophagus | ESCC | 3.31e-12 | 5.14e-01 | 0.0667 |
23518 | R3HDM1 | LZE8T | Human | Esophagus | ESCC | 1.26e-04 | 2.05e-01 | 0.067 |
23518 | R3HDM1 | LZE24T | Human | Esophagus | ESCC | 1.04e-14 | 3.24e-01 | 0.0596 |
23518 | R3HDM1 | P1T-E | Human | Esophagus | ESCC | 1.16e-02 | 1.73e-01 | 0.0875 |
23518 | R3HDM1 | P2T-E | Human | Esophagus | ESCC | 9.90e-23 | 4.50e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
R3HDM1 | SNV | Missense_Mutation | c.522G>T | p.Leu174Phe | p.L174F | Q15032 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0YT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | arimidex | SD | |
R3HDM1 | SNV | Missense_Mutation | c.503N>T | p.Arg168Ile | p.R168I | Q15032 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
R3HDM1 | SNV | Missense_Mutation | c.11N>T | p.Ser4Phe | p.S4F | Q15032 | protein_coding | deleterious(0) | possibly_damaging(0.603) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
R3HDM1 | insertion | Frame_Shift_Ins | novel | c.1461_1462insGAGCCAATGCTTTTATGTAGTAACTGCATGTTATGCAATGT | p.Asn488GlufsTer23 | p.N488Efs*23 | Q15032 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
R3HDM1 | SNV | Missense_Mutation | rs778568401 | c.757C>T | p.Arg253Cys | p.R253C | Q15032 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
R3HDM1 | SNV | Missense_Mutation | c.1256G>A | p.Gly419Asp | p.G419D | Q15032 | protein_coding | deleterious(0.04) | probably_damaging(0.942) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
R3HDM1 | SNV | Missense_Mutation | c.577N>T | p.Pro193Ser | p.P193S | Q15032 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
R3HDM1 | SNV | Missense_Mutation | rs755222892 | c.239N>A | p.Arg80Gln | p.R80Q | Q15032 | protein_coding | deleterious(0) | benign(0.005) | TCGA-3L-AA1B-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
R3HDM1 | SNV | Missense_Mutation | rs747738172 | c.1318N>A | p.Ala440Thr | p.A440T | Q15032 | protein_coding | tolerated(0.6) | benign(0) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
R3HDM1 | SNV | Missense_Mutation | c.409N>G | p.Leu137Val | p.L137V | Q15032 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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