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Gene: PTRF |
Gene summary for PTRF |
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Gene information | Species | Human | Gene symbol | PTRF | Gene ID | 284119 |
Gene name | caveolae associated protein 1 | |
Gene Alias | CAVIN | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6NZI2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284119 | PTRF | LZE4T | Human | Esophagus | ESCC | 1.05e-04 | -5.14e-01 | 0.0811 |
284119 | PTRF | LZE8T | Human | Esophagus | ESCC | 4.47e-04 | -5.14e-01 | 0.067 |
284119 | PTRF | LZE20T | Human | Esophagus | ESCC | 3.50e-04 | -5.14e-01 | 0.0662 |
284119 | PTRF | LZE24T | Human | Esophagus | ESCC | 1.87e-07 | -5.14e-01 | 0.0596 |
284119 | PTRF | LZE6T | Human | Esophagus | ESCC | 4.12e-02 | -5.14e-01 | 0.0845 |
284119 | PTRF | P2T-E | Human | Esophagus | ESCC | 1.53e-24 | 6.47e-01 | 0.1177 |
284119 | PTRF | P4T-E | Human | Esophagus | ESCC | 1.03e-21 | 9.49e-01 | 0.1323 |
284119 | PTRF | P5T-E | Human | Esophagus | ESCC | 9.44e-29 | 8.20e-01 | 0.1327 |
284119 | PTRF | P8T-E | Human | Esophagus | ESCC | 2.83e-04 | 4.85e-01 | 0.0889 |
284119 | PTRF | P9T-E | Human | Esophagus | ESCC | 4.27e-14 | 8.54e-01 | 0.1131 |
284119 | PTRF | P10T-E | Human | Esophagus | ESCC | 1.63e-15 | 5.48e-01 | 0.116 |
284119 | PTRF | P11T-E | Human | Esophagus | ESCC | 3.24e-21 | 1.38e+00 | 0.1426 |
284119 | PTRF | P12T-E | Human | Esophagus | ESCC | 9.19e-50 | 1.35e+00 | 0.1122 |
284119 | PTRF | P15T-E | Human | Esophagus | ESCC | 3.57e-19 | 1.09e+00 | 0.1149 |
284119 | PTRF | P16T-E | Human | Esophagus | ESCC | 2.32e-45 | 1.19e+00 | 0.1153 |
284119 | PTRF | P17T-E | Human | Esophagus | ESCC | 1.25e-17 | 1.39e+00 | 0.1278 |
284119 | PTRF | P19T-E | Human | Esophagus | ESCC | 3.23e-14 | 2.03e+00 | 0.1662 |
284119 | PTRF | P20T-E | Human | Esophagus | ESCC | 1.98e-27 | 8.63e-01 | 0.1124 |
284119 | PTRF | P21T-E | Human | Esophagus | ESCC | 1.75e-51 | 1.86e+00 | 0.1617 |
284119 | PTRF | P22T-E | Human | Esophagus | ESCC | 1.96e-10 | 2.49e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTRF | SNV | Missense_Mutation | novel | c.981N>C | p.Lys327Asn | p.K327N | Q6NZI2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTRF | SNV | Missense_Mutation | c.797N>T | p.Thr266Met | p.T266M | Q6NZI2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
PTRF | SNV | Missense_Mutation | novel | c.1060N>C | p.Glu354Gln | p.E354Q | Q6NZI2 | protein_coding | tolerated(0.07) | benign(0.354) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
PTRF | SNV | Missense_Mutation | c.104N>T | p.Pro35Leu | p.P35L | Q6NZI2 | protein_coding | tolerated(0.12) | benign(0.001) | TCGA-D8-A1XV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTRF | SNV | Missense_Mutation | novel | c.941N>T | p.Ala314Val | p.A314V | Q6NZI2 | protein_coding | deleterious(0) | benign(0.242) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PTRF | SNV | Missense_Mutation | novel | c.838N>T | p.Arg280Cys | p.R280C | Q6NZI2 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-VS-A9V5-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
PTRF | SNV | Missense_Mutation | c.506G>A | p.Ser169Asn | p.S169N | Q6NZI2 | protein_coding | tolerated(0.14) | benign(0.092) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PTRF | SNV | Missense_Mutation | c.652N>A | p.Ala218Thr | p.A218T | Q6NZI2 | protein_coding | tolerated(0.1) | benign(0.214) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PTRF | SNV | Missense_Mutation | novel | c.586N>A | p.Ala196Thr | p.A196T | Q6NZI2 | protein_coding | tolerated(0.57) | benign(0) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTRF | SNV | Missense_Mutation | c.764N>T | p.Thr255Met | p.T255M | Q6NZI2 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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