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Gene: PTGS2 |
Gene summary for PTGS2 |
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Gene information | Species | Human | Gene symbol | PTGS2 | Gene ID | 5743 |
Gene name | prostaglandin-endoperoxide synthase 2 | |
Gene Alias | COX-2 | |
Cytomap | 1q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P35354 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5743 | PTGS2 | P75T-E | Human | Esophagus | ESCC | 9.07e-04 | 5.52e-01 | 0.1125 |
5743 | PTGS2 | P79T-E | Human | Esophagus | ESCC | 3.23e-02 | 3.07e-01 | 0.1154 |
5743 | PTGS2 | P128T-E | Human | Esophagus | ESCC | 8.06e-08 | 7.48e-01 | 0.1241 |
5743 | PTGS2 | C04 | Human | Oral cavity | OSCC | 2.83e-13 | 1.15e+00 | 0.2633 |
5743 | PTGS2 | LP15 | Human | Oral cavity | LP | 4.15e-02 | 2.00e+00 | 0.2174 |
5743 | PTGS2 | EOLP-1 | Human | Oral cavity | EOLP | 1.17e-02 | 3.32e-01 | -0.0202 |
5743 | PTGS2 | NEOLP-1 | Human | Oral cavity | NEOLP | 3.11e-03 | 3.27e-01 | -0.0194 |
5743 | PTGS2 | SYSMH3 | Human | Oral cavity | OSCC | 2.47e-13 | 1.14e+00 | 0.2442 |
5743 | PTGS2 | GSM5252126_BPH283PrGF_Via | Human | Prostate | BPH | 1.44e-06 | 6.59e-01 | -0.1771 |
5743 | PTGS2 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 1.43e-22 | 1.53e+00 | -0.1972 |
5743 | PTGS2 | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 3.25e-02 | 5.90e-01 | -0.2126 |
5743 | PTGS2 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 2.48e-02 | 1.45e+00 | -0.2247 |
5743 | PTGS2 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 6.96e-11 | 3.19e+00 | -0.2027 |
5743 | PTGS2 | GSM5252134_BPH511PrG_Fcol_3GEX | Human | Prostate | BPH | 7.20e-08 | 8.21e-01 | -0.1433 |
5743 | PTGS2 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 3.26e-12 | 1.57e+00 | -0.1833 |
5743 | PTGS2 | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 1.15e-04 | 6.52e-01 | -0.23 |
5743 | PTGS2 | 047563_1562-all-cells | Human | Prostate | BPH | 4.87e-13 | 4.47e-01 | 0.0791 |
5743 | PTGS2 | 048752_1579-all-cells | Human | Prostate | BPH | 2.29e-07 | 2.32e-01 | 0.1008 |
5743 | PTGS2 | 052095_1628-all-cells | Human | Prostate | BPH | 3.43e-18 | 5.38e-01 | 0.1032 |
5743 | PTGS2 | Dong_P1 | Human | Prostate | Tumor | 2.85e-40 | 5.08e-01 | 0.035 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009719310 | Cervix | CC | intrinsic apoptotic signaling pathway | 85/2311 | 288/18723 | 4.56e-15 | 6.46e-12 | 85 |
GO:200123310 | Cervix | CC | regulation of apoptotic signaling pathway | 96/2311 | 356/18723 | 4.08e-14 | 3.05e-11 | 96 |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:005254810 | Cervix | CC | regulation of endopeptidase activity | 103/2311 | 432/18723 | 1.89e-11 | 5.14e-09 | 103 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:200124210 | Cervix | CC | regulation of intrinsic apoptotic signaling pathway | 52/2311 | 164/18723 | 5.06e-11 | 1.01e-08 | 52 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:000697910 | Cervix | CC | response to oxidative stress | 102/2311 | 446/18723 | 2.99e-10 | 4.36e-08 | 102 |
GO:190382910 | Cervix | CC | positive regulation of cellular protein localization | 72/2311 | 276/18723 | 3.20e-10 | 4.46e-08 | 72 |
GO:007149610 | Cervix | CC | cellular response to external stimulus | 78/2311 | 320/18723 | 1.82e-09 | 1.98e-07 | 78 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:00321035 | Cervix | CC | positive regulation of response to external stimulus | 95/2311 | 427/18723 | 5.44e-09 | 5.03e-07 | 95 |
GO:200011610 | Cervix | CC | regulation of cysteine-type endopeptidase activity | 61/2311 | 235/18723 | 8.69e-09 | 7.22e-07 | 61 |
GO:005122210 | Cervix | CC | positive regulation of protein transport | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:004328110 | Cervix | CC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 55/2311 | 209/18723 | 2.77e-08 | 1.95e-06 | 55 |
GO:004586110 | Cervix | CC | negative regulation of proteolysis | 80/2311 | 351/18723 | 2.88e-08 | 1.98e-06 | 80 |
GO:00069139 | Cervix | CC | nucleocytoplasmic transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501018 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0502218 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0516720 | Cervix | CC | Kaposi sarcoma-associated herpesvirus infection | 60/1267 | 194/8465 | 9.74e-09 | 1.58e-07 | 9.33e-08 | 60 |
hsa0516318 | Cervix | CC | Human cytomegalovirus infection | 65/1267 | 225/8465 | 4.59e-08 | 6.47e-07 | 3.83e-07 | 65 |
hsa0465718 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0472318 | Cervix | CC | Retrograde endocannabinoid signaling | 42/1267 | 148/8465 | 1.79e-05 | 1.42e-04 | 8.40e-05 | 42 |
hsa052226 | Cervix | CC | Small cell lung cancer | 29/1267 | 92/8465 | 4.38e-05 | 3.09e-04 | 1.83e-04 | 29 |
hsa051657 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa0514014 | Cervix | CC | Leishmaniasis | 21/1267 | 77/8465 | 3.65e-03 | 1.34e-02 | 7.91e-03 | 21 |
hsa046686 | Cervix | CC | TNF signaling pathway | 28/1267 | 114/8465 | 4.60e-03 | 1.62e-02 | 9.59e-03 | 28 |
hsa046254 | Cervix | CC | C-type lectin receptor signaling pathway | 25/1267 | 104/8465 | 9.52e-03 | 2.94e-02 | 1.74e-02 | 25 |
hsa049218 | Cervix | CC | Oxytocin signaling pathway | 34/1267 | 154/8465 | 1.12e-02 | 3.42e-02 | 2.02e-02 | 34 |
hsa0501019 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0502219 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa05167110 | Cervix | CC | Kaposi sarcoma-associated herpesvirus infection | 60/1267 | 194/8465 | 9.74e-09 | 1.58e-07 | 9.33e-08 | 60 |
hsa0516319 | Cervix | CC | Human cytomegalovirus infection | 65/1267 | 225/8465 | 4.59e-08 | 6.47e-07 | 3.83e-07 | 65 |
hsa0465719 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0472319 | Cervix | CC | Retrograde endocannabinoid signaling | 42/1267 | 148/8465 | 1.79e-05 | 1.42e-04 | 8.40e-05 | 42 |
hsa0522213 | Cervix | CC | Small cell lung cancer | 29/1267 | 92/8465 | 4.38e-05 | 3.09e-04 | 1.83e-04 | 29 |
hsa0516512 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTGS2 | SNV | Missense_Mutation | novel | c.1298N>A | p.Val433Glu | p.V433E | P35354 | protein_coding | deleterious(0.01) | benign(0.219) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTGS2 | SNV | Missense_Mutation | rs200204426 | c.898G>A | p.Asp300Asn | p.D300N | P35354 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTGS2 | SNV | Missense_Mutation | c.112G>A | p.Asp38Asn | p.D38N | P35354 | protein_coding | tolerated(0.1) | benign(0.014) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
PTGS2 | SNV | Missense_Mutation | c.691C>T | p.Arg231Cys | p.R231C | P35354 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A1QZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PTGS2 | SNV | Missense_Mutation | c.297N>A | p.Met99Ile | p.M99I | P35354 | protein_coding | deleterious(0) | possibly_damaging(0.672) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
PTGS2 | SNV | Missense_Mutation | novel | c.1565G>A | p.Gly522Asp | p.G522D | P35354 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PTGS2 | SNV | Missense_Mutation | c.1358G>A | p.Arg453His | p.R453H | P35354 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PTGS2 | SNV | Missense_Mutation | rs200132172 | c.284G>A | p.Arg95Gln | p.R95Q | P35354 | protein_coding | tolerated(0.11) | benign(0.028) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PTGS2 | SNV | Missense_Mutation | c.1738N>G | p.Asn580Asp | p.N580D | P35354 | protein_coding | tolerated(0.11) | benign(0.205) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTGS2 | SNV | Missense_Mutation | novel | c.1492N>G | p.Pro498Ala | p.P498A | P35354 | protein_coding | tolerated(0.19) | benign(0.011) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | Tolmetin | TOLMETIN | ||
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL599 | MELOXICAM | |
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | IBUPROFEN | IBUPROFEN | ||
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | PHENYLBUTAZONE | PHENYLBUTAZONE | ||
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | NEPAFENAC | NEPAFENAC | ||
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL2105683 | NAPROXEN ETEMESIL | |
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | atenolol | ATENOLOL | ||
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL876 | MECLOFENAMATE SODIUM | |
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | OXAPROZIN | OXAPROZIN | ||
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | KETOPROFEN | KETOPROFEN |
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