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Gene: PROCR |
Gene summary for PROCR |
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Gene information | Species | Human | Gene symbol | PROCR | Gene ID | 10544 |
Gene name | protein C receptor | |
Gene Alias | CCCA | |
Cytomap | 20q11.22 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | Q9UNN8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10544 | PROCR | P37T-E | Human | Esophagus | ESCC | 1.29e-22 | 4.80e-01 | 0.1371 |
10544 | PROCR | P38T-E | Human | Esophagus | ESCC | 3.82e-04 | 1.51e-01 | 0.127 |
10544 | PROCR | P42T-E | Human | Esophagus | ESCC | 1.26e-02 | 1.74e-01 | 0.1175 |
10544 | PROCR | P47T-E | Human | Esophagus | ESCC | 5.01e-11 | 6.07e-02 | 0.1067 |
10544 | PROCR | P49T-E | Human | Esophagus | ESCC | 1.35e-09 | 1.12e+00 | 0.1768 |
10544 | PROCR | P52T-E | Human | Esophagus | ESCC | 2.57e-13 | 4.43e-01 | 0.1555 |
10544 | PROCR | P56T-E | Human | Esophagus | ESCC | 1.19e-03 | 5.88e-01 | 0.1613 |
10544 | PROCR | P61T-E | Human | Esophagus | ESCC | 9.66e-11 | 3.55e-01 | 0.099 |
10544 | PROCR | P62T-E | Human | Esophagus | ESCC | 2.11e-04 | 1.79e-01 | 0.1302 |
10544 | PROCR | P74T-E | Human | Esophagus | ESCC | 1.57e-11 | 4.32e-01 | 0.1479 |
10544 | PROCR | P75T-E | Human | Esophagus | ESCC | 9.06e-16 | 5.71e-01 | 0.1125 |
10544 | PROCR | P76T-E | Human | Esophagus | ESCC | 4.87e-07 | 2.03e-01 | 0.1207 |
10544 | PROCR | P79T-E | Human | Esophagus | ESCC | 4.05e-23 | 5.64e-01 | 0.1154 |
10544 | PROCR | P80T-E | Human | Esophagus | ESCC | 3.78e-22 | 7.66e-01 | 0.155 |
10544 | PROCR | P82T-E | Human | Esophagus | ESCC | 1.90e-04 | 3.70e-01 | 0.1072 |
10544 | PROCR | P83T-E | Human | Esophagus | ESCC | 2.67e-22 | 9.00e-01 | 0.1738 |
10544 | PROCR | P89T-E | Human | Esophagus | ESCC | 1.14e-18 | 1.46e+00 | 0.1752 |
10544 | PROCR | P91T-E | Human | Esophagus | ESCC | 1.77e-22 | 2.24e+00 | 0.1828 |
10544 | PROCR | P107T-E | Human | Esophagus | ESCC | 2.78e-28 | 7.24e-01 | 0.171 |
10544 | PROCR | P126T-E | Human | Esophagus | ESCC | 3.85e-02 | 3.41e-01 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:004206020 | Oral cavity | OSCC | wound healing | 237/7305 | 422/18723 | 4.51e-13 | 2.18e-11 | 237 |
GO:005087819 | Oral cavity | OSCC | regulation of body fluid levels | 179/7305 | 379/18723 | 6.19e-04 | 3.50e-03 | 179 |
GO:00075969 | Oral cavity | OSCC | blood coagulation | 102/7305 | 217/18723 | 9.69e-03 | 3.43e-02 | 102 |
GO:00075999 | Oral cavity | OSCC | hemostasis | 103/7305 | 222/18723 | 1.45e-02 | 4.73e-02 | 103 |
GO:00508179 | Oral cavity | OSCC | coagulation | 103/7305 | 222/18723 | 1.45e-02 | 4.73e-02 | 103 |
GO:0042060110 | Oral cavity | LP | wound healing | 139/4623 | 422/18723 | 7.10e-05 | 9.48e-04 | 139 |
GO:004206026 | Oral cavity | EOLP | wound healing | 99/2218 | 422/18723 | 1.18e-11 | 1.85e-09 | 99 |
GO:005081715 | Oral cavity | EOLP | coagulation | 43/2218 | 222/18723 | 7.59e-04 | 6.09e-03 | 43 |
GO:000759615 | Oral cavity | EOLP | blood coagulation | 42/2218 | 217/18723 | 8.81e-04 | 6.76e-03 | 42 |
GO:000759915 | Oral cavity | EOLP | hemostasis | 42/2218 | 222/18723 | 1.40e-03 | 9.58e-03 | 42 |
GO:0050878110 | Oral cavity | EOLP | regulation of body fluid levels | 63/2218 | 379/18723 | 3.36e-03 | 1.94e-02 | 63 |
GO:004206033 | Oral cavity | NEOLP | wound healing | 106/2005 | 422/18723 | 1.93e-17 | 1.91e-14 | 106 |
GO:005081722 | Oral cavity | NEOLP | coagulation | 48/2005 | 222/18723 | 1.51e-06 | 3.77e-05 | 48 |
GO:000759621 | Oral cavity | NEOLP | blood coagulation | 47/2005 | 217/18723 | 1.84e-06 | 4.44e-05 | 47 |
GO:000759921 | Oral cavity | NEOLP | hemostasis | 47/2005 | 222/18723 | 3.57e-06 | 7.85e-05 | 47 |
GO:005087825 | Oral cavity | NEOLP | regulation of body fluid levels | 70/2005 | 379/18723 | 3.62e-06 | 7.94e-05 | 70 |
GO:00508184 | Oral cavity | NEOLP | regulation of coagulation | 16/2005 | 71/18723 | 2.95e-03 | 1.81e-02 | 16 |
GO:004206029 | Skin | cSCC | wound healing | 152/4864 | 422/18723 | 2.66e-06 | 4.26e-05 | 152 |
GO:004206034 | Thyroid | ATC | wound healing | 210/6293 | 422/18723 | 3.33e-12 | 1.37e-10 | 210 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PROCR | SNV | Missense_Mutation | novel | c.201N>G | p.Ile67Met | p.I67M | Q9UNN8 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
PROCR | SNV | Missense_Mutation | novel | c.545T>G | p.Leu182Arg | p.L182R | Q9UNN8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
PROCR | SNV | Missense_Mutation | rs762831201 | c.611N>A | p.Thr204Lys | p.T204K | Q9UNN8 | protein_coding | tolerated(0.19) | possibly_damaging(0.555) | TCGA-A8-A06R-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
PROCR | SNV | Missense_Mutation | c.6G>T | p.Leu2Phe | p.L2F | Q9UNN8 | protein_coding | tolerated_low_confidence(0.2) | possibly_damaging(0.605) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PROCR | SNV | Missense_Mutation | c.390N>A | p.Phe130Leu | p.F130L | Q9UNN8 | protein_coding | deleterious(0) | possibly_damaging(0.776) | TCGA-AN-A0AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PROCR | SNV | Missense_Mutation | rs762831201 | c.611N>A | p.Thr204Lys | p.T204K | Q9UNN8 | protein_coding | tolerated(0.19) | possibly_damaging(0.555) | TCGA-AR-A1AP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
PROCR | SNV | Missense_Mutation | rs762831201 | c.611C>A | p.Thr204Lys | p.T204K | Q9UNN8 | protein_coding | tolerated(0.19) | possibly_damaging(0.555) | TCGA-BH-A1EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PROCR | SNV | Missense_Mutation | rs762831201 | c.611N>A | p.Thr204Lys | p.T204K | Q9UNN8 | protein_coding | tolerated(0.19) | possibly_damaging(0.555) | TCGA-C8-A12X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PROCR | SNV | Missense_Mutation | rs762831201 | c.611C>A | p.Thr204Lys | p.T204K | Q9UNN8 | protein_coding | tolerated(0.19) | possibly_damaging(0.555) | TCGA-D8-A1XG-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PROCR | SNV | Missense_Mutation | c.517N>T | p.Arg173Cys | p.R173C | Q9UNN8 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10544 | PROCR | DRUGGABLE GENOME, CELL SURFACE | GED-APC |
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