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Gene: PRELID2 |
Gene summary for PRELID2 |
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Gene information | Species | Human | Gene symbol | PRELID2 | Gene ID | 153768 |
Gene name | PRELI domain containing 2 | |
Gene Alias | PRELID2 | |
Cytomap | 5q32 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8N945 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
153768 | PRELID2 | A002-C-205 | Human | Colorectum | FAP | 3.97e-27 | -6.29e-01 | -0.1236 |
153768 | PRELID2 | A001-C-104 | Human | Colorectum | FAP | 5.65e-10 | -6.15e-01 | 0.0184 |
153768 | PRELID2 | A015-C-005 | Human | Colorectum | FAP | 4.15e-04 | -3.82e-01 | -0.0336 |
153768 | PRELID2 | A015-C-006 | Human | Colorectum | FAP | 4.31e-19 | -6.32e-01 | -0.0994 |
153768 | PRELID2 | A015-C-106 | Human | Colorectum | FAP | 1.80e-07 | -2.22e-01 | -0.0511 |
153768 | PRELID2 | A002-C-114 | Human | Colorectum | FAP | 3.84e-18 | -4.10e-01 | -0.1561 |
153768 | PRELID2 | A015-C-104 | Human | Colorectum | FAP | 1.10e-29 | -6.09e-01 | -0.1899 |
153768 | PRELID2 | A001-C-014 | Human | Colorectum | FAP | 3.93e-18 | -5.92e-01 | 0.0135 |
153768 | PRELID2 | A002-C-016 | Human | Colorectum | FAP | 2.39e-15 | -9.06e-02 | 0.0521 |
153768 | PRELID2 | A015-C-002 | Human | Colorectum | FAP | 1.47e-16 | -6.30e-01 | -0.0763 |
153768 | PRELID2 | A001-C-007 | Human | Colorectum | CRC | 1.29e-08 | -7.42e-01 | 0.1899 |
153768 | PRELID2 | A001-C-203 | Human | Colorectum | FAP | 5.43e-11 | -3.39e-01 | -0.0481 |
153768 | PRELID2 | A002-C-116 | Human | Colorectum | FAP | 1.69e-34 | -4.02e-01 | -0.0452 |
153768 | PRELID2 | A014-C-008 | Human | Colorectum | FAP | 8.22e-19 | -6.69e-01 | -0.191 |
153768 | PRELID2 | A018-E-020 | Human | Colorectum | FAP | 1.77e-18 | -3.34e-02 | -0.2034 |
153768 | PRELID2 | F034 | Human | Colorectum | FAP | 1.16e-15 | -2.93e-01 | -0.0665 |
153768 | PRELID2 | F072B | Human | Colorectum | FAP | 2.91e-20 | 4.05e-01 | 0.257 |
153768 | PRELID2 | CRC-1-8810 | Human | Colorectum | CRC | 1.18e-05 | -3.88e-01 | 0.6257 |
153768 | PRELID2 | CRC-3-11773 | Human | Colorectum | CRC | 9.36e-05 | -3.46e-01 | 0.2564 |
153768 | PRELID2 | LZE4T | Human | Esophagus | ESCC | 6.42e-08 | 1.75e-01 | 0.0811 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:00068691 | Colorectum | FAP | lipid transport | 81/2622 | 398/18723 | 2.84e-04 | 3.76e-03 | 81 |
GO:00108762 | Colorectum | FAP | lipid localization | 85/2622 | 448/18723 | 1.92e-03 | 1.63e-02 | 85 |
GO:0015914 | Colorectum | FAP | phospholipid transport | 23/2622 | 96/18723 | 6.09e-03 | 3.82e-02 | 23 |
GO:00068692 | Colorectum | CRC | lipid transport | 63/2078 | 398/18723 | 2.36e-03 | 2.26e-02 | 63 |
GO:00108763 | Colorectum | CRC | lipid localization | 68/2078 | 448/18723 | 4.60e-03 | 3.58e-02 | 68 |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:01200092 | Liver | HCC | intermembrane lipid transfer | 33/7958 | 48/18723 | 2.12e-04 | 1.63e-03 | 33 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
GO:00159142 | Lung | IAC | phospholipid transport | 20/2061 | 96/18723 | 3.58e-03 | 3.00e-02 | 20 |
GO:00157482 | Lung | IAC | organophosphate ester transport | 26/2061 | 140/18723 | 5.22e-03 | 3.97e-02 | 26 |
GO:001591411 | Lung | AIS | phospholipid transport | 18/1849 | 96/18723 | 5.64e-03 | 4.76e-02 | 18 |
GO:00157483 | Oral cavity | EOLP | organophosphate ester transport | 28/2218 | 140/18723 | 3.66e-03 | 2.05e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRELID2 | SNV | Missense_Mutation | novel | c.209C>T | p.Ser70Phe | p.S70F | Q8N945 | protein_coding | tolerated_low_confidence(0.71) | benign(0.001) | TCGA-DS-A7WH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PRELID2 | SNV | Missense_Mutation | c.220C>G | p.Leu74Val | p.L74V | Q8N945 | protein_coding | tolerated_low_confidence(0.58) | benign(0.113) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PRELID2 | SNV | Missense_Mutation | c.244N>A | p.Val82Met | p.V82M | Q8N945 | protein_coding | tolerated(0.11) | possibly_damaging(0.682) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
PRELID2 | SNV | Missense_Mutation | novel | c.551N>T | p.Gly184Val | p.G184V | Q8N945 | protein_coding | deleterious(0.01) | probably_damaging(0.965) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
PRELID2 | SNV | Missense_Mutation | rs761566160 | c.115N>G | p.Ile39Val | p.I39V | Q8N945 | protein_coding | tolerated(0.47) | benign(0.003) | TCGA-B5-A1MZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PRELID2 | SNV | Missense_Mutation | novel | c.348G>T | p.Gln116His | p.Q116H | Q8N945 | protein_coding | tolerated(0.08) | probably_damaging(0.927) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PRELID2 | SNV | Missense_Mutation | novel | c.16G>A | p.Asp6Asn | p.D6N | Q8N945 | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PRELID2 | SNV | Missense_Mutation | novel | c.382N>A | p.Glu128Lys | p.E128K | Q8N945 | protein_coding | tolerated(0.21) | possibly_damaging(0.872) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRELID2 | SNV | Missense_Mutation | novel | c.302G>T | p.Arg101Leu | p.R101L | Q8N945 | protein_coding | deleterious(0.02) | benign(0.134) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRELID2 | SNV | Missense_Mutation | novel | c.95N>C | p.Lys32Thr | p.K32T | Q8N945 | protein_coding | deleterious(0.02) | possibly_damaging(0.832) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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