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Gene: PRAP1 |
Gene summary for PRAP1 |
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Gene information | Species | Human | Gene symbol | PRAP1 | Gene ID | 118471 |
Gene name | proline rich acidic protein 1 | |
Gene Alias | PRO1195 | |
Cytomap | 10q26.3 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | A6XND8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
118471 | PRAP1 | S027 | Human | Liver | HCC | 5.76e-10 | 1.01e+00 | 0.2446 |
118471 | PRAP1 | S028 | Human | Liver | HCC | 1.34e-40 | 1.44e+00 | 0.2503 |
118471 | PRAP1 | S029 | Human | Liver | HCC | 5.24e-56 | 2.13e+00 | 0.2581 |
118471 | PRAP1 | Pat01-B | Human | Stomach | GC | 1.23e-102 | 1.82e+00 | 0.5754 |
118471 | PRAP1 | Pat02-B | Human | Stomach | GC | 1.87e-35 | 8.10e-01 | 0.0368 |
118471 | PRAP1 | Pat03-B | Human | Stomach | GC | 3.14e-62 | 1.46e+00 | 0.3693 |
118471 | PRAP1 | Pat04-B | Human | Stomach | GC | 2.07e-05 | 2.67e-01 | -0.1483 |
118471 | PRAP1 | Pat05-B | Human | Stomach | GC | 5.89e-16 | 7.88e-01 | -0.0353 |
118471 | PRAP1 | Pat07-B | Human | Stomach | GC | 5.61e-12 | 6.22e-01 | 0.0935 |
118471 | PRAP1 | Pat08-B | Human | Stomach | GC | 2.56e-24 | 9.83e-01 | 0.0182 |
118471 | PRAP1 | Pat09-B | Human | Stomach | GC | 8.28e-03 | 1.65e-01 | -0.0359 |
118471 | PRAP1 | Pat10-B | Human | Stomach | GC | 1.20e-19 | 9.84e-01 | 0.084 |
118471 | PRAP1 | Pat12-B | Human | Stomach | GC | 2.17e-10 | 3.63e-01 | 0.0325 |
118471 | PRAP1 | Pat13-B | Human | Stomach | GC | 3.56e-04 | 2.22e-01 | 0.0555 |
118471 | PRAP1 | Pat16-B | Human | Stomach | GC | 2.61e-20 | 7.24e-01 | 0.1918 |
118471 | PRAP1 | Pat17-B | Human | Stomach | GC | 1.32e-60 | 1.51e+00 | 0.3109 |
118471 | PRAP1 | Pat18-B | Human | Stomach | GC | 2.85e-04 | 2.64e-01 | -0.0432 |
118471 | PRAP1 | Pat19-B | Human | Stomach | GC | 1.36e-16 | 5.79e-01 | 0.0826 |
118471 | PRAP1 | Pat24-B | Human | Stomach | GC | 4.15e-03 | 2.01e-01 | -0.1184 |
118471 | PRAP1 | Pat25-A | Human | Stomach | CAG with IM | 8.81e-05 | 2.34e-01 | -0.1648 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:2001252 | Colorectum | AD | positive regulation of chromosome organization | 35/3918 | 82/18723 | 6.90e-06 | 1.72e-04 | 35 |
GO:0072331 | Colorectum | AD | signal transduction by p53 class mediator | 58/3918 | 163/18723 | 1.04e-05 | 2.40e-04 | 58 |
GO:0033044 | Colorectum | AD | regulation of chromosome organization | 60/3918 | 187/18723 | 2.25e-04 | 2.94e-03 | 60 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0071481 | Colorectum | AD | cellular response to X-ray | 8/3918 | 14/18723 | 3.23e-03 | 2.38e-02 | 8 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:0030330 | Colorectum | AD | DNA damage response, signal transduction by p53 class mediator | 25/3918 | 72/18723 | 4.65e-03 | 3.16e-02 | 25 |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:0045842 | Colorectum | AD | positive regulation of mitotic metaphase/anaphase transition | 8/3918 | 15/18723 | 5.67e-03 | 3.64e-02 | 8 |
GO:1901970 | Colorectum | AD | positive regulation of mitotic sister chromatid separation | 8/3918 | 15/18723 | 5.67e-03 | 3.64e-02 | 8 |
GO:1905820 | Colorectum | AD | positive regulation of chromosome separation | 9/3918 | 18/18723 | 5.82e-03 | 3.67e-02 | 9 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:0045931 | Colorectum | AD | positive regulation of mitotic cell cycle | 37/3918 | 121/18723 | 7.88e-03 | 4.73e-02 | 37 |
GO:00106391 | Colorectum | SER | negative regulation of organelle organization | 90/2897 | 348/18723 | 3.14e-07 | 1.69e-05 | 90 |
GO:20012521 | Colorectum | SER | positive regulation of chromosome organization | 27/2897 | 82/18723 | 6.44e-05 | 1.49e-03 | 27 |
GO:00723311 | Colorectum | SER | signal transduction by p53 class mediator | 43/2897 | 163/18723 | 2.22e-04 | 3.90e-03 | 43 |
GO:0022600 | Colorectum | SER | digestive system process | 29/2897 | 104/18723 | 8.57e-04 | 1.05e-02 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa041402 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041403 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa041404 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa041405 | Colorectum | MSS | Autophagy - animal | 45/1875 | 141/8465 | 4.42e-03 | 1.90e-02 | 1.16e-02 | 45 |
hsa041406 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa0414011 | Liver | Cirrhotic | Autophagy - animal | 65/2530 | 141/8465 | 3.10e-05 | 2.47e-04 | 1.52e-04 | 65 |
hsa0414021 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa0414031 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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