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Gene: PPP1R14B |
Gene summary for PPP1R14B |
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Gene information | Species | Human | Gene symbol | PPP1R14B | Gene ID | 26472 |
Gene name | protein phosphatase 1 regulatory inhibitor subunit 14B | |
Gene Alias | PHI-1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q96C90 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26472 | PPP1R14B | M2 | Human | Breast | IDC | 1.69e-39 | 1.08e+00 | 0.21 |
26472 | PPP1R14B | NCCBC11 | Human | Breast | DCIS | 5.17e-04 | 2.12e-01 | 0.1232 |
26472 | PPP1R14B | NCCBC14 | Human | Breast | DCIS | 6.87e-26 | 4.38e-01 | 0.2021 |
26472 | PPP1R14B | NCCBC2 | Human | Breast | DCIS | 5.83e-04 | 3.44e-02 | 0.1554 |
26472 | PPP1R14B | NCCBC3 | Human | Breast | DCIS | 5.88e-06 | 2.12e-01 | 0.1198 |
26472 | PPP1R14B | NCCBC5 | Human | Breast | DCIS | 1.10e-14 | 7.31e-02 | 0.2046 |
26472 | PPP1R14B | NCCBC6 | Human | Breast | DCIS | 7.00e-04 | 3.90e-01 | 0.2095 |
26472 | PPP1R14B | P1 | Human | Breast | IDC | 4.96e-20 | -1.82e-01 | 0.1527 |
26472 | PPP1R14B | P2 | Human | Breast | IDC | 3.21e-22 | 5.10e-01 | 0.21 |
26472 | PPP1R14B | DCIS2 | Human | Breast | DCIS | 9.24e-51 | 5.01e-01 | 0.0085 |
26472 | PPP1R14B | CA_HPV_1 | Human | Cervix | CC | 4.35e-17 | 2.61e-01 | 0.0264 |
26472 | PPP1R14B | CA_HPV_3 | Human | Cervix | CC | 1.85e-02 | 2.06e-01 | 0.0414 |
26472 | PPP1R14B | CCI_1 | Human | Cervix | CC | 6.98e-09 | -7.31e-01 | 0.528 |
26472 | PPP1R14B | CCI_3 | Human | Cervix | CC | 3.32e-12 | -7.34e-01 | 0.516 |
26472 | PPP1R14B | CCII_1 | Human | Cervix | CC | 1.50e-19 | -7.66e-01 | 0.3249 |
26472 | PPP1R14B | sample3 | Human | Cervix | CC | 3.21e-05 | 1.86e-01 | 0.1387 |
26472 | PPP1R14B | L1 | Human | Cervix | CC | 1.10e-05 | 1.95e-01 | 0.0802 |
26472 | PPP1R14B | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.23e-12 | 2.32e-01 | 0.0155 |
26472 | PPP1R14B | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.31e-17 | 4.36e-01 | -0.1808 |
26472 | PPP1R14B | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.84e-04 | 2.80e-01 | 0.0216 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP1R14B | SNV | Missense_Mutation | novel | c.435N>C | p.Gln145His | p.Q145H | Q96C90 | protein_coding | deleterious(0.01) | possibly_damaging(0.864) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
PPP1R14B | SNV | Missense_Mutation | c.262N>A | p.Glu88Lys | p.E88K | Q96C90 | protein_coding | deleterious(0.02) | possibly_damaging(0.538) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
PPP1R14B | SNV | Missense_Mutation | novel | c.148N>C | p.Val50Leu | p.V50L | Q96C90 | protein_coding | tolerated(0.7) | benign(0.189) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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