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Gene: PPIL3 |
Gene summary for PPIL3 |
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Gene information | Species | Human | Gene symbol | PPIL3 | Gene ID | 53938 |
Gene name | peptidylprolyl isomerase like 3 | |
Gene Alias | CYPJ | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | A0A0S2Z5A8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
53938 | PPIL3 | P23T-E | Human | Esophagus | ESCC | 3.99e-15 | 2.76e-01 | 0.108 |
53938 | PPIL3 | P24T-E | Human | Esophagus | ESCC | 2.92e-15 | 1.67e-01 | 0.1287 |
53938 | PPIL3 | P26T-E | Human | Esophagus | ESCC | 1.50e-19 | 3.07e-01 | 0.1276 |
53938 | PPIL3 | P27T-E | Human | Esophagus | ESCC | 6.61e-16 | 3.10e-01 | 0.1055 |
53938 | PPIL3 | P28T-E | Human | Esophagus | ESCC | 1.61e-09 | 1.78e-01 | 0.1149 |
53938 | PPIL3 | P30T-E | Human | Esophagus | ESCC | 9.01e-14 | 5.52e-01 | 0.137 |
53938 | PPIL3 | P31T-E | Human | Esophagus | ESCC | 3.24e-19 | 2.65e-01 | 0.1251 |
53938 | PPIL3 | P32T-E | Human | Esophagus | ESCC | 3.82e-20 | 4.13e-01 | 0.1666 |
53938 | PPIL3 | P36T-E | Human | Esophagus | ESCC | 2.09e-06 | 1.83e-01 | 0.1187 |
53938 | PPIL3 | P37T-E | Human | Esophagus | ESCC | 1.04e-17 | 1.80e-01 | 0.1371 |
53938 | PPIL3 | P38T-E | Human | Esophagus | ESCC | 1.58e-03 | 2.00e-01 | 0.127 |
53938 | PPIL3 | P39T-E | Human | Esophagus | ESCC | 2.92e-15 | 3.08e-01 | 0.0894 |
53938 | PPIL3 | P40T-E | Human | Esophagus | ESCC | 2.54e-06 | 1.43e-01 | 0.109 |
53938 | PPIL3 | P42T-E | Human | Esophagus | ESCC | 2.57e-14 | 3.18e-01 | 0.1175 |
53938 | PPIL3 | P44T-E | Human | Esophagus | ESCC | 1.15e-05 | 8.89e-02 | 0.1096 |
53938 | PPIL3 | P47T-E | Human | Esophagus | ESCC | 4.25e-05 | 6.10e-02 | 0.1067 |
53938 | PPIL3 | P48T-E | Human | Esophagus | ESCC | 1.27e-04 | 1.92e-01 | 0.0959 |
53938 | PPIL3 | P49T-E | Human | Esophagus | ESCC | 3.54e-05 | 5.30e-01 | 0.1768 |
53938 | PPIL3 | P52T-E | Human | Esophagus | ESCC | 8.26e-18 | 4.16e-01 | 0.1555 |
53938 | PPIL3 | P54T-E | Human | Esophagus | ESCC | 3.99e-17 | 3.65e-01 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:001820816 | Esophagus | ESCC | peptidyl-proline modification | 46/8552 | 58/18723 | 1.59e-07 | 2.51e-06 | 46 |
GO:000041313 | Esophagus | ESCC | protein peptidyl-prolyl isomerization | 32/8552 | 42/18723 | 5.52e-05 | 4.27e-04 | 32 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:000037519 | Oral cavity | OSCC | RNA splicing, via transesterification reactions | 225/7305 | 324/18723 | 5.20e-29 | 2.99e-26 | 225 |
GO:000037719 | Oral cavity | OSCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:000039819 | Oral cavity | OSCC | mRNA splicing, via spliceosome | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:000645718 | Oral cavity | OSCC | protein folding | 154/7305 | 212/18723 | 1.89e-23 | 4.60e-21 | 154 |
GO:00182088 | Oral cavity | OSCC | peptidyl-proline modification | 42/7305 | 58/18723 | 2.49e-07 | 3.92e-06 | 42 |
GO:00004134 | Oral cavity | OSCC | protein peptidyl-prolyl isomerization | 28/7305 | 42/18723 | 2.61e-04 | 1.67e-03 | 28 |
GO:0008380110 | Oral cavity | LP | RNA splicing | 237/4623 | 434/18723 | 1.82e-41 | 3.79e-38 | 237 |
GO:0000375110 | Oral cavity | LP | RNA splicing, via transesterification reactions | 181/4623 | 324/18723 | 1.36e-33 | 1.70e-30 | 181 |
GO:0000377110 | Oral cavity | LP | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
GO:0000398110 | Oral cavity | LP | mRNA splicing, via spliceosome | 179/4623 | 320/18723 | 2.48e-33 | 2.22e-30 | 179 |
GO:000645719 | Oral cavity | LP | protein folding | 125/4623 | 212/18723 | 1.62e-26 | 8.45e-24 | 125 |
GO:001820815 | Oral cavity | LP | peptidyl-proline modification | 28/4623 | 58/18723 | 8.35e-05 | 1.07e-03 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPIL3 | SNV | Missense_Mutation | c.219N>T | p.Lys73Asn | p.K73N | Q9H2H8 | protein_coding | tolerated(0.28) | benign(0.413) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PPIL3 | SNV | Missense_Mutation | c.242N>T | p.Glu81Val | p.E81V | Q9H2H8 | protein_coding | deleterious(0.03) | benign(0.036) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PPIL3 | SNV | Missense_Mutation | c.241N>A | p.Glu81Lys | p.E81K | Q9H2H8 | protein_coding | deleterious(0.04) | benign(0.197) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PPIL3 | SNV | Missense_Mutation | c.332N>T | p.Lys111Ile | p.K111I | Q9H2H8 | protein_coding | deleterious(0.01) | possibly_damaging(0.856) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PPIL3 | SNV | Missense_Mutation | rs369410002 | c.466A>G | p.Ile156Val | p.I156V | Q9H2H8 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPIL3 | SNV | Missense_Mutation | rs61730410 | c.361N>A | p.Val121Ile | p.V121I | Q9H2H8 | protein_coding | tolerated(0.58) | benign(0.026) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPIL3 | SNV | Missense_Mutation | c.307T>G | p.Ser103Ala | p.S103A | Q9H2H8 | protein_coding | deleterious(0.04) | possibly_damaging(0.809) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PPIL3 | SNV | Missense_Mutation | novel | c.485N>A | p.Pro162Gln | p.P162Q | Q9H2H8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PPIL3 | SNV | Missense_Mutation | c.318N>A | p.Phe106Leu | p.F106L | Q9H2H8 | protein_coding | deleterious(0) | possibly_damaging(0.68) | TCGA-78-7542-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PPIL3 | SNV | Missense_Mutation | c.238N>T | p.Ser80Cys | p.S80C | Q9H2H8 | protein_coding | deleterious(0.03) | possibly_damaging(0.748) | TCGA-70-6723-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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