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Gene: PIP5K1B |
Gene summary for PIP5K1B |
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Gene information | Species | Human | Gene symbol | PIP5K1B | Gene ID | 8395 |
Gene name | phosphatidylinositol-4-phosphate 5-kinase type 1 beta | |
Gene Alias | MSS4 | |
Cytomap | 9q21.11 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | O14986 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8395 | PIP5K1B | A015-C-006 | Human | Colorectum | FAP | 8.26e-25 | -7.28e-01 | -0.0994 |
8395 | PIP5K1B | A015-C-106 | Human | Colorectum | FAP | 9.87e-08 | -3.30e-01 | -0.0511 |
8395 | PIP5K1B | A002-C-114 | Human | Colorectum | FAP | 4.21e-23 | -6.01e-01 | -0.1561 |
8395 | PIP5K1B | A015-C-104 | Human | Colorectum | FAP | 1.12e-34 | -6.95e-01 | -0.1899 |
8395 | PIP5K1B | A001-C-014 | Human | Colorectum | FAP | 1.47e-18 | -4.92e-01 | 0.0135 |
8395 | PIP5K1B | A002-C-016 | Human | Colorectum | FAP | 1.04e-28 | -4.25e-01 | 0.0521 |
8395 | PIP5K1B | A015-C-002 | Human | Colorectum | FAP | 8.07e-21 | -8.08e-01 | -0.0763 |
8395 | PIP5K1B | A001-C-203 | Human | Colorectum | FAP | 1.74e-05 | -2.29e-01 | -0.0481 |
8395 | PIP5K1B | A002-C-116 | Human | Colorectum | FAP | 1.33e-36 | -4.81e-01 | -0.0452 |
8395 | PIP5K1B | A014-C-008 | Human | Colorectum | FAP | 4.03e-22 | -8.01e-01 | -0.191 |
8395 | PIP5K1B | A018-E-020 | Human | Colorectum | FAP | 1.67e-27 | -6.59e-01 | -0.2034 |
8395 | PIP5K1B | F034 | Human | Colorectum | FAP | 4.04e-14 | -2.27e-01 | -0.0665 |
8395 | PIP5K1B | CRC-1-8810 | Human | Colorectum | CRC | 1.98e-06 | 2.98e-01 | 0.6257 |
8395 | PIP5K1B | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 4.95e-14 | 6.95e-01 | -0.2116 |
8395 | PIP5K1B | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 6.85e-03 | 5.47e-01 | -0.1941 |
8395 | PIP5K1B | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.72e-17 | 7.89e-01 | -0.2119 |
8395 | PIP5K1B | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.37e-02 | 1.06e-01 | -0.013 |
8395 | PIP5K1B | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.49e-03 | 2.02e-01 | -0.0121 |
8395 | PIP5K1B | Pat01-B | Human | Stomach | GC | 1.20e-39 | 7.38e-01 | 0.5754 |
8395 | PIP5K1B | Pat02-B | Human | Stomach | GC | 1.15e-36 | 4.00e-01 | 0.0368 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048017 | Colorectum | AD | inositol lipid-mediated signaling | 53/3918 | 182/18723 | 5.35e-03 | 3.52e-02 | 53 |
GO:0048015 | Colorectum | AD | phosphatidylinositol-mediated signaling | 52/3918 | 178/18723 | 5.37e-03 | 3.54e-02 | 52 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
GO:00480171 | Colorectum | SER | inositol lipid-mediated signaling | 42/2897 | 182/18723 | 4.36e-03 | 3.49e-02 | 42 |
GO:00450171 | Colorectum | SER | glycerolipid biosynthetic process | 55/2897 | 252/18723 | 4.47e-03 | 3.56e-02 | 55 |
GO:00480151 | Colorectum | SER | phosphatidylinositol-mediated signaling | 41/2897 | 178/18723 | 4.97e-03 | 3.86e-02 | 41 |
GO:00066501 | Colorectum | SER | glycerophospholipid metabolic process | 64/2897 | 306/18723 | 6.41e-03 | 4.60e-02 | 64 |
GO:0008654 | Colorectum | FAP | phospholipid biosynthetic process | 54/2622 | 253/18723 | 8.88e-04 | 9.08e-03 | 54 |
GO:00066502 | Colorectum | FAP | glycerophospholipid metabolic process | 62/2622 | 306/18723 | 1.54e-03 | 1.38e-02 | 62 |
GO:00066442 | Colorectum | FAP | phospholipid metabolic process | 74/2622 | 383/18723 | 2.24e-03 | 1.83e-02 | 74 |
GO:0046474 | Colorectum | FAP | glycerophospholipid biosynthetic process | 44/2622 | 211/18723 | 3.98e-03 | 2.76e-02 | 44 |
GO:00450172 | Colorectum | FAP | glycerolipid biosynthetic process | 50/2622 | 252/18723 | 6.32e-03 | 3.95e-02 | 50 |
GO:00086541 | Colorectum | CRC | phospholipid biosynthetic process | 49/2078 | 253/18723 | 7.07e-05 | 1.51e-03 | 49 |
GO:00066503 | Colorectum | CRC | glycerophospholipid metabolic process | 55/2078 | 306/18723 | 2.10e-04 | 3.55e-03 | 55 |
GO:00450173 | Colorectum | CRC | glycerolipid biosynthetic process | 47/2078 | 252/18723 | 2.47e-04 | 4.06e-03 | 47 |
GO:00066443 | Colorectum | CRC | phospholipid metabolic process | 65/2078 | 383/18723 | 3.21e-04 | 4.95e-03 | 65 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa04666 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa04810 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa04510 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa046661 | Colorectum | AD | Fc gamma R-mediated phagocytosis | 46/2092 | 97/8465 | 9.10e-07 | 1.22e-05 | 7.77e-06 | 46 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa048101 | Colorectum | AD | Regulation of actin cytoskeleton | 75/2092 | 229/8465 | 3.36e-03 | 1.76e-02 | 1.12e-02 | 75 |
hsa045101 | Colorectum | AD | Focal adhesion | 67/2092 | 203/8465 | 4.40e-03 | 2.17e-02 | 1.38e-02 | 67 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa046662 | Colorectum | SER | Fc gamma R-mediated phagocytosis | 39/1580 | 97/8465 | 5.84e-07 | 9.70e-06 | 7.04e-06 | 39 |
hsa051352 | Colorectum | SER | Yersinia infection | 43/1580 | 137/8465 | 2.15e-04 | 2.10e-03 | 1.52e-03 | 43 |
hsa048102 | Colorectum | SER | Regulation of actin cytoskeleton | 60/1580 | 229/8465 | 2.74e-03 | 2.02e-02 | 1.47e-02 | 60 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa046663 | Colorectum | SER | Fc gamma R-mediated phagocytosis | 39/1580 | 97/8465 | 5.84e-07 | 9.70e-06 | 7.04e-06 | 39 |
hsa051353 | Colorectum | SER | Yersinia infection | 43/1580 | 137/8465 | 2.15e-04 | 2.10e-03 | 1.52e-03 | 43 |
hsa048103 | Colorectum | SER | Regulation of actin cytoskeleton | 60/1580 | 229/8465 | 2.74e-03 | 2.02e-02 | 1.47e-02 | 60 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa046664 | Colorectum | MSS | Fc gamma R-mediated phagocytosis | 45/1875 | 97/8465 | 9.30e-08 | 1.56e-06 | 9.55e-07 | 45 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PIP5K1B | SNV | Missense_Mutation | rs781715849 | c.644G>A | p.Arg215His | p.R215H | O14986 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PIP5K1B | SNV | Missense_Mutation | rs766949478 | c.623C>T | p.Thr208Met | p.T208M | O14986 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-E9-A245-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
PIP5K1B | SNV | Missense_Mutation | novel | c.622N>G | p.Thr208Ala | p.T208A | O14986 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PIP5K1B | deletion | Frame_Shift_Del | novel | c.646delN | p.Glu217ArgfsTer12 | p.E217Rfs*12 | O14986 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PIP5K1B | SNV | Missense_Mutation | rs775224955 | c.1612N>A | p.Val538Ile | p.V538I | O14986 | protein_coding | tolerated_low_confidence(0.23) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PIP5K1B | SNV | Missense_Mutation | c.778N>C | p.Glu260Gln | p.E260Q | O14986 | protein_coding | tolerated(0.34) | benign(0.145) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PIP5K1B | SNV | Missense_Mutation | novel | c.953N>A | p.Gly318Glu | p.G318E | O14986 | protein_coding | tolerated(0.08) | benign(0.062) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
PIP5K1B | SNV | Missense_Mutation | c.739G>A | p.Ala247Thr | p.A247T | O14986 | protein_coding | deleterious(0.01) | benign(0.298) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
PIP5K1B | SNV | Missense_Mutation | c.157N>A | p.Leu53Ile | p.L53I | O14986 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PIP5K1B | SNV | Missense_Mutation | rs746948673 | c.706G>A | p.Glu236Lys | p.E236K | O14986 | protein_coding | tolerated(0.08) | benign(0.063) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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