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Gene: PINLYP |
Gene summary for PINLYP |
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Gene information | Species | Human | Gene symbol | PINLYP | Gene ID | 390940 |
Gene name | phospholipase A2 inhibitor and LY6/PLAUR domain containing | |
Gene Alias | PINLYP | |
Cytomap | 19q13.31 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A6NC86 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
390940 | PINLYP | P47T-E | Human | Esophagus | ESCC | 4.65e-08 | 7.33e-02 | 0.1067 |
390940 | PINLYP | P48T-E | Human | Esophagus | ESCC | 6.93e-06 | 5.78e-02 | 0.0959 |
390940 | PINLYP | P49T-E | Human | Esophagus | ESCC | 2.33e-14 | 1.48e+00 | 0.1768 |
390940 | PINLYP | P52T-E | Human | Esophagus | ESCC | 2.75e-03 | 4.71e-02 | 0.1555 |
390940 | PINLYP | P54T-E | Human | Esophagus | ESCC | 4.62e-08 | 2.86e-01 | 0.0975 |
390940 | PINLYP | P57T-E | Human | Esophagus | ESCC | 2.67e-04 | 9.21e-02 | 0.0926 |
390940 | PINLYP | P65T-E | Human | Esophagus | ESCC | 4.84e-04 | 5.08e-02 | 0.0978 |
390940 | PINLYP | P74T-E | Human | Esophagus | ESCC | 2.05e-25 | 9.62e-01 | 0.1479 |
390940 | PINLYP | P79T-E | Human | Esophagus | ESCC | 2.69e-11 | 3.36e-01 | 0.1154 |
390940 | PINLYP | P80T-E | Human | Esophagus | ESCC | 2.88e-05 | 2.32e-01 | 0.155 |
390940 | PINLYP | P83T-E | Human | Esophagus | ESCC | 3.83e-17 | 8.00e-01 | 0.1738 |
390940 | PINLYP | P91T-E | Human | Esophagus | ESCC | 5.86e-05 | 5.35e-01 | 0.1828 |
390940 | PINLYP | P107T-E | Human | Esophagus | ESCC | 2.02e-18 | 6.05e-01 | 0.171 |
390940 | PINLYP | P128T-E | Human | Esophagus | ESCC | 1.06e-06 | 2.83e-01 | 0.1241 |
390940 | PINLYP | P130T-E | Human | Esophagus | ESCC | 1.26e-56 | 1.16e+00 | 0.1676 |
390940 | PINLYP | C04 | Human | Oral cavity | OSCC | 9.18e-04 | 4.69e-01 | 0.2633 |
390940 | PINLYP | C21 | Human | Oral cavity | OSCC | 6.82e-10 | 4.32e-01 | 0.2678 |
390940 | PINLYP | C30 | Human | Oral cavity | OSCC | 6.17e-21 | 1.01e+00 | 0.3055 |
390940 | PINLYP | C46 | Human | Oral cavity | OSCC | 1.01e-12 | 3.82e-01 | 0.1673 |
390940 | PINLYP | C51 | Human | Oral cavity | OSCC | 1.25e-02 | 2.88e-01 | 0.2674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PINLYP | SNV | Missense_Mutation | novel | c.149C>T | p.Pro50Leu | p.P50L | A6NC86 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PINLYP | SNV | Missense_Mutation | novel | c.603N>A | p.Met201Ile | p.M201I | A6NC86 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-D1-A2G0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PINLYP | deletion | Frame_Shift_Del | novel | c.339delN | p.Gly114AlafsTer7 | p.G114Afs*7 | A6NC86 | protein_coding | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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