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Gene: PIN4 |
Gene summary for PIN4 |
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Gene information | Species | Human | Gene symbol | PIN4 | Gene ID | 5303 |
Gene name | peptidylprolyl cis/trans isomerase, NIMA-interacting 4 | |
Gene Alias | EPVH | |
Cytomap | Xq13.1 | |
Gene Type | protein-coding | GO ID | GO:0000413 | UniProtAcc | Q9Y237 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5303 | PIN4 | DCIS2 | Human | Breast | DCIS | 1.54e-50 | 6.28e-02 | 0.0085 |
5303 | PIN4 | AEH-subject1 | Human | Endometrium | AEH | 4.62e-06 | -2.10e-01 | -0.3059 |
5303 | PIN4 | AEH-subject2 | Human | Endometrium | AEH | 6.11e-04 | -2.15e-01 | -0.2525 |
5303 | PIN4 | AEH-subject3 | Human | Endometrium | AEH | 1.08e-08 | -2.15e-01 | -0.2576 |
5303 | PIN4 | AEH-subject4 | Human | Endometrium | AEH | 2.94e-05 | -3.07e-01 | -0.2657 |
5303 | PIN4 | AEH-subject5 | Human | Endometrium | AEH | 3.01e-10 | -3.53e-01 | -0.2953 |
5303 | PIN4 | EEC-subject1 | Human | Endometrium | EEC | 1.26e-17 | -3.31e-01 | -0.2682 |
5303 | PIN4 | EEC-subject2 | Human | Endometrium | EEC | 1.00e-07 | -2.68e-01 | -0.2607 |
5303 | PIN4 | EEC-subject3 | Human | Endometrium | EEC | 8.19e-33 | -3.74e-01 | -0.2525 |
5303 | PIN4 | EEC-subject4 | Human | Endometrium | EEC | 3.61e-08 | -3.15e-01 | -0.2571 |
5303 | PIN4 | EEC-subject5 | Human | Endometrium | EEC | 7.13e-11 | -3.37e-01 | -0.249 |
5303 | PIN4 | GSM5276934 | Human | Endometrium | EEC | 3.96e-15 | -3.88e-01 | -0.0913 |
5303 | PIN4 | GSM5276937 | Human | Endometrium | EEC | 2.42e-06 | -3.36e-01 | -0.0897 |
5303 | PIN4 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.04e-23 | -3.03e-01 | -0.1869 |
5303 | PIN4 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.23e-20 | -2.84e-01 | -0.1875 |
5303 | PIN4 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 5.33e-23 | -2.23e-01 | -0.1883 |
5303 | PIN4 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.59e-29 | -2.78e-01 | -0.1934 |
5303 | PIN4 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 4.65e-32 | -2.50e-01 | -0.1917 |
5303 | PIN4 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 9.79e-36 | -3.44e-01 | -0.1916 |
5303 | PIN4 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 4.65e-03 | 2.44e-02 | -0.1269 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00422549 | Breast | Precancer | ribosome biogenesis | 52/1080 | 299/18723 | 7.35e-13 | 1.51e-10 | 52 |
GO:00063646 | Breast | Precancer | rRNA processing | 35/1080 | 225/18723 | 7.90e-08 | 4.60e-06 | 35 |
GO:00160726 | Breast | Precancer | rRNA metabolic process | 36/1080 | 236/18723 | 8.59e-08 | 4.84e-06 | 36 |
GO:00344705 | Breast | Precancer | ncRNA processing | 42/1080 | 395/18723 | 9.91e-05 | 1.83e-03 | 42 |
GO:00346604 | Breast | Precancer | ncRNA metabolic process | 45/1080 | 485/18723 | 1.15e-03 | 1.26e-02 | 45 |
GO:00182085 | Breast | Precancer | peptidyl-proline modification | 10/1080 | 58/18723 | 1.62e-03 | 1.65e-02 | 10 |
GO:002261314 | Breast | IDC | ribonucleoprotein complex biogenesis | 83/1434 | 463/18723 | 2.01e-13 | 5.20e-11 | 83 |
GO:004225414 | Breast | IDC | ribosome biogenesis | 52/1434 | 299/18723 | 1.90e-08 | 1.32e-06 | 52 |
GO:000636414 | Breast | IDC | rRNA processing | 35/1434 | 225/18723 | 4.59e-05 | 1.03e-03 | 35 |
GO:001607214 | Breast | IDC | rRNA metabolic process | 36/1434 | 236/18723 | 5.48e-05 | 1.17e-03 | 36 |
GO:001820812 | Breast | IDC | peptidyl-proline modification | 13/1434 | 58/18723 | 3.59e-04 | 5.18e-03 | 13 |
GO:002261324 | Breast | DCIS | ribonucleoprotein complex biogenesis | 83/1390 | 463/18723 | 3.65e-14 | 1.09e-11 | 83 |
GO:004225423 | Breast | DCIS | ribosome biogenesis | 52/1390 | 299/18723 | 6.73e-09 | 5.44e-07 | 52 |
GO:000636422 | Breast | DCIS | rRNA processing | 35/1390 | 225/18723 | 2.41e-05 | 5.62e-04 | 35 |
GO:001607222 | Breast | DCIS | rRNA metabolic process | 36/1390 | 236/18723 | 2.86e-05 | 6.42e-04 | 36 |
GO:001820821 | Breast | DCIS | peptidyl-proline modification | 13/1390 | 58/18723 | 2.65e-04 | 4.03e-03 | 13 |
GO:003447011 | Breast | DCIS | ncRNA processing | 44/1390 | 395/18723 | 4.56e-03 | 3.49e-02 | 44 |
GO:002261316 | Endometrium | AEH | ribonucleoprotein complex biogenesis | 107/2100 | 463/18723 | 1.43e-13 | 4.08e-11 | 107 |
GO:004225416 | Endometrium | AEH | ribosome biogenesis | 67/2100 | 299/18723 | 1.95e-08 | 1.18e-06 | 67 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PIN4 | SNV | Missense_Mutation | c.261N>A | p.Met87Ile | p.M87I | Q9Y237 | protein_coding | tolerated(0.23) | benign(0.015) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
PIN4 | SNV | Missense_Mutation | novel | c.113G>A | p.Gly38Glu | p.G38E | Q9Y237 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PIN4 | insertion | Frame_Shift_Ins | novel | c.309_310insT | p.Gly104TrpfsTer3 | p.G104Wfs*3 | Q9Y237 | protein_coding | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
PIN4 | SNV | Missense_Mutation | novel | c.185N>T | p.Ala62Val | p.A62V | Q9Y237 | protein_coding | deleterious(0.02) | possibly_damaging(0.602) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PIN4 | SNV | Missense_Mutation | c.191N>G | p.Lys64Arg | p.K64R | Q9Y237 | protein_coding | deleterious(0.03) | possibly_damaging(0.732) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PIN4 | SNV | Missense_Mutation | rs756299765 | c.457G>A | p.Glu153Lys | p.E153K | Q9Y237 | protein_coding | deleterious(0.03) | possibly_damaging(0.88) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PIN4 | SNV | Missense_Mutation | novel | c.374N>T | p.Ala125Val | p.A125V | Q9Y237 | protein_coding | deleterious(0.03) | benign(0.24) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
PIN4 | SNV | Missense_Mutation | c.353N>A | p.Pro118Gln | p.P118Q | Q9Y237 | protein_coding | tolerated(0.05) | possibly_damaging(0.844) | TCGA-FV-A3I1-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PIN4 | SNV | Missense_Mutation | c.156N>T | p.Lys52Asn | p.K52N | Q9Y237 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
PIN4 | SNV | Missense_Mutation | novel | c.80C>A | p.Pro27Gln | p.P27Q | Q9Y237 | protein_coding | deleterious(0) | possibly_damaging(0.68) | TCGA-39-5039-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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