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Gene: PIGZ |
Gene summary for PIGZ |
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Gene information | Species | Human | Gene symbol | PIGZ | Gene ID | 80235 |
Gene name | phosphatidylinositol glycan anchor biosynthesis class Z | |
Gene Alias | GPI-MT-IV | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | B4DL68 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80235 | PIGZ | A002-C-203 | Human | Colorectum | FAP | 7.06e-05 | -2.99e-01 | 0.2786 |
80235 | PIGZ | A001-C-119 | Human | Colorectum | FAP | 6.86e-09 | -5.41e-01 | -0.1557 |
80235 | PIGZ | A001-C-108 | Human | Colorectum | FAP | 9.27e-10 | -1.90e-01 | -0.0272 |
80235 | PIGZ | A002-C-205 | Human | Colorectum | FAP | 1.61e-20 | -5.14e-01 | -0.1236 |
80235 | PIGZ | A001-C-104 | Human | Colorectum | FAP | 2.97e-04 | -1.17e-01 | 0.0184 |
80235 | PIGZ | A015-C-005 | Human | Colorectum | FAP | 3.12e-03 | -2.71e-01 | -0.0336 |
80235 | PIGZ | A015-C-006 | Human | Colorectum | FAP | 5.30e-14 | -4.50e-01 | -0.0994 |
80235 | PIGZ | A015-C-106 | Human | Colorectum | FAP | 3.41e-09 | -1.57e-01 | -0.0511 |
80235 | PIGZ | A002-C-114 | Human | Colorectum | FAP | 2.63e-14 | -4.02e-01 | -0.1561 |
80235 | PIGZ | A015-C-104 | Human | Colorectum | FAP | 9.95e-21 | -3.34e-01 | -0.1899 |
80235 | PIGZ | A015-C-202 | Human | Colorectum | FAP | 9.95e-05 | 3.49e-01 | -0.0849 |
80235 | PIGZ | A001-C-014 | Human | Colorectum | FAP | 3.75e-09 | -3.10e-01 | 0.0135 |
80235 | PIGZ | A002-C-016 | Human | Colorectum | FAP | 8.63e-20 | -4.74e-01 | 0.0521 |
80235 | PIGZ | A015-C-002 | Human | Colorectum | FAP | 1.71e-09 | -2.73e-01 | -0.0763 |
80235 | PIGZ | A001-C-007 | Human | Colorectum | CRC | 1.60e-05 | -5.18e-01 | 0.1899 |
80235 | PIGZ | A001-C-203 | Human | Colorectum | FAP | 1.07e-07 | -2.06e-01 | -0.0481 |
80235 | PIGZ | A002-C-116 | Human | Colorectum | FAP | 8.72e-26 | -4.86e-01 | -0.0452 |
80235 | PIGZ | A014-C-008 | Human | Colorectum | FAP | 6.03e-10 | -2.12e-01 | -0.191 |
80235 | PIGZ | A018-E-020 | Human | Colorectum | FAP | 4.95e-15 | -2.61e-01 | -0.2034 |
80235 | PIGZ | F034 | Human | Colorectum | FAP | 5.57e-18 | -4.88e-01 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
GO:00450171 | Colorectum | SER | glycerolipid biosynthetic process | 55/2897 | 252/18723 | 4.47e-03 | 3.56e-02 | 55 |
GO:00066501 | Colorectum | SER | glycerophospholipid metabolic process | 64/2897 | 306/18723 | 6.41e-03 | 4.60e-02 | 64 |
GO:0008654 | Colorectum | FAP | phospholipid biosynthetic process | 54/2622 | 253/18723 | 8.88e-04 | 9.08e-03 | 54 |
GO:00066502 | Colorectum | FAP | glycerophospholipid metabolic process | 62/2622 | 306/18723 | 1.54e-03 | 1.38e-02 | 62 |
GO:00066442 | Colorectum | FAP | phospholipid metabolic process | 74/2622 | 383/18723 | 2.24e-03 | 1.83e-02 | 74 |
GO:00700851 | Colorectum | FAP | glycosylation | 50/2622 | 240/18723 | 2.30e-03 | 1.85e-02 | 50 |
GO:0046474 | Colorectum | FAP | glycerophospholipid biosynthetic process | 44/2622 | 211/18723 | 3.98e-03 | 2.76e-02 | 44 |
GO:00450172 | Colorectum | FAP | glycerolipid biosynthetic process | 50/2622 | 252/18723 | 6.32e-03 | 3.95e-02 | 50 |
GO:00086541 | Colorectum | CRC | phospholipid biosynthetic process | 49/2078 | 253/18723 | 7.07e-05 | 1.51e-03 | 49 |
GO:00066503 | Colorectum | CRC | glycerophospholipid metabolic process | 55/2078 | 306/18723 | 2.10e-04 | 3.55e-03 | 55 |
GO:00450173 | Colorectum | CRC | glycerolipid biosynthetic process | 47/2078 | 252/18723 | 2.47e-04 | 4.06e-03 | 47 |
GO:00066443 | Colorectum | CRC | phospholipid metabolic process | 65/2078 | 383/18723 | 3.21e-04 | 4.95e-03 | 65 |
GO:00464741 | Colorectum | CRC | glycerophospholipid biosynthetic process | 40/2078 | 211/18723 | 4.91e-04 | 7.02e-03 | 40 |
GO:00464861 | Colorectum | CRC | glycerolipid metabolic process | 64/2078 | 392/18723 | 1.01e-03 | 1.19e-02 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa005632 | Esophagus | ESCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 21/4205 | 26/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 21 |
hsa0056311 | Esophagus | ESCC | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 21/4205 | 26/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 21 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PIGZ | SNV | Missense_Mutation | rs202160888 | c.604C>T | p.Arg202Cys | p.R202C | Q86VD9 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-A8-A08X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | PD |
PIGZ | SNV | Missense_Mutation | rs752266694 | c.488N>G | p.Ser163Cys | p.S163C | Q86VD9 | protein_coding | deleterious(0.01) | possibly_damaging(0.754) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
PIGZ | SNV | Missense_Mutation | c.700N>A | p.Ala234Thr | p.A234T | Q86VD9 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PIGZ | insertion | Frame_Shift_Ins | novel | c.1431_1432insACCCA | p.Leu478ThrfsTer24 | p.L478Tfs*24 | Q86VD9 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
PIGZ | insertion | Frame_Shift_Ins | novel | c.1429_1430insACAATATGACAGA | p.Gly477AspfsTer19 | p.G477Dfs*19 | Q86VD9 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
PIGZ | deletion | Frame_Shift_Del | c.457delN | p.Ala153ArgfsTer44 | p.A153Rfs*44 | Q86VD9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
PIGZ | deletion | Frame_Shift_Del | rs774420515 | c.1467delN | p.Thr490LeufsTer10 | p.T490Lfs*10 | Q86VD9 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
PIGZ | SNV | Missense_Mutation | c.1267N>A | p.Gly423Ser | p.G423S | Q86VD9 | protein_coding | deleterious(0.03) | possibly_damaging(0.548) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PIGZ | SNV | Missense_Mutation | novel | c.1320N>T | p.Glu440Asp | p.E440D | Q86VD9 | protein_coding | tolerated(0.62) | benign(0.062) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PIGZ | deletion | Frame_Shift_Del | rs774420515 | c.1467delN | p.Thr490LeufsTer10 | p.T490Lfs*10 | Q86VD9 | protein_coding | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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