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Gene: PIGBOS1 |
Gene summary for PIGBOS1 |
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Gene information | Species | Human | Gene symbol | PIGBOS1 | Gene ID | 101928527 |
Gene name | PIGB opposite strand 1 | |
Gene Alias | HP06981 | |
Cytomap | 15q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | A0A0B4J2F0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
101928527 | PIGBOS1 | P20T-E | Human | Esophagus | ESCC | 1.24e-20 | 3.53e-01 | 0.1124 |
101928527 | PIGBOS1 | P21T-E | Human | Esophagus | ESCC | 8.30e-15 | 1.57e-01 | 0.1617 |
101928527 | PIGBOS1 | P22T-E | Human | Esophagus | ESCC | 5.44e-25 | 4.00e-01 | 0.1236 |
101928527 | PIGBOS1 | P23T-E | Human | Esophagus | ESCC | 2.15e-24 | 5.89e-01 | 0.108 |
101928527 | PIGBOS1 | P24T-E | Human | Esophagus | ESCC | 4.04e-13 | 2.13e-01 | 0.1287 |
101928527 | PIGBOS1 | P26T-E | Human | Esophagus | ESCC | 2.73e-26 | 3.74e-01 | 0.1276 |
101928527 | PIGBOS1 | P27T-E | Human | Esophagus | ESCC | 8.56e-13 | 1.59e-01 | 0.1055 |
101928527 | PIGBOS1 | P28T-E | Human | Esophagus | ESCC | 1.17e-15 | 2.79e-01 | 0.1149 |
101928527 | PIGBOS1 | P30T-E | Human | Esophagus | ESCC | 7.73e-15 | 4.90e-01 | 0.137 |
101928527 | PIGBOS1 | P31T-E | Human | Esophagus | ESCC | 7.44e-21 | 3.07e-01 | 0.1251 |
101928527 | PIGBOS1 | P32T-E | Human | Esophagus | ESCC | 1.37e-23 | 3.92e-01 | 0.1666 |
101928527 | PIGBOS1 | P36T-E | Human | Esophagus | ESCC | 2.56e-12 | 2.17e-01 | 0.1187 |
101928527 | PIGBOS1 | P37T-E | Human | Esophagus | ESCC | 2.60e-10 | 2.23e-01 | 0.1371 |
101928527 | PIGBOS1 | P39T-E | Human | Esophagus | ESCC | 5.01e-09 | 2.00e-01 | 0.0894 |
101928527 | PIGBOS1 | P42T-E | Human | Esophagus | ESCC | 2.20e-23 | 4.50e-01 | 0.1175 |
101928527 | PIGBOS1 | P44T-E | Human | Esophagus | ESCC | 4.63e-07 | 2.01e-01 | 0.1096 |
101928527 | PIGBOS1 | P47T-E | Human | Esophagus | ESCC | 2.47e-17 | 2.55e-01 | 0.1067 |
101928527 | PIGBOS1 | P48T-E | Human | Esophagus | ESCC | 1.43e-14 | 2.38e-01 | 0.0959 |
101928527 | PIGBOS1 | P49T-E | Human | Esophagus | ESCC | 9.49e-04 | 3.58e-01 | 0.1768 |
101928527 | PIGBOS1 | P52T-E | Human | Esophagus | ESCC | 1.73e-24 | 4.14e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034976111 | Esophagus | ESCC | response to endoplasmic reticulum stress | 192/8552 | 256/18723 | 7.15e-22 | 1.30e-19 | 192 |
GO:0035966111 | Esophagus | ESCC | response to topologically incorrect protein | 125/8552 | 159/18723 | 1.44e-17 | 1.27e-15 | 125 |
GO:0006986111 | Esophagus | ESCC | response to unfolded protein | 107/8552 | 137/18723 | 7.01e-15 | 3.87e-13 | 107 |
GO:0035967111 | Esophagus | ESCC | cellular response to topologically incorrect protein | 90/8552 | 116/18723 | 1.94e-12 | 8.11e-11 | 90 |
GO:0034620111 | Esophagus | ESCC | cellular response to unfolded protein | 74/8552 | 96/18723 | 3.10e-10 | 8.66e-09 | 74 |
GO:003096818 | Esophagus | ESCC | endoplasmic reticulum unfolded protein response | 59/8552 | 74/18723 | 1.90e-09 | 4.36e-08 | 59 |
GO:1905897111 | Esophagus | ESCC | regulation of response to endoplasmic reticulum stress | 63/8552 | 82/18723 | 8.16e-09 | 1.66e-07 | 63 |
GO:190010110 | Esophagus | ESCC | regulation of endoplasmic reticulum unfolded protein response | 24/8552 | 30/18723 | 1.27e-04 | 8.67e-04 | 24 |
GO:00349767 | Liver | Cirrhotic | response to endoplasmic reticulum stress | 130/4634 | 256/18723 | 1.72e-19 | 3.86e-17 | 130 |
GO:00359667 | Liver | Cirrhotic | response to topologically incorrect protein | 91/4634 | 159/18723 | 2.07e-18 | 3.60e-16 | 91 |
GO:00069867 | Liver | Cirrhotic | response to unfolded protein | 79/4634 | 137/18723 | 1.99e-16 | 2.49e-14 | 79 |
GO:00359677 | Liver | Cirrhotic | cellular response to topologically incorrect protein | 64/4634 | 116/18723 | 2.20e-12 | 1.62e-10 | 64 |
GO:00346207 | Liver | Cirrhotic | cellular response to unfolded protein | 54/4634 | 96/18723 | 4.16e-11 | 2.42e-09 | 54 |
GO:00309686 | Liver | Cirrhotic | endoplasmic reticulum unfolded protein response | 43/4634 | 74/18723 | 9.86e-10 | 4.48e-08 | 43 |
GO:19058977 | Liver | Cirrhotic | regulation of response to endoplasmic reticulum stress | 46/4634 | 82/18723 | 1.28e-09 | 5.56e-08 | 46 |
GO:19001015 | Liver | Cirrhotic | regulation of endoplasmic reticulum unfolded protein response | 19/4634 | 30/18723 | 8.57e-06 | 1.27e-04 | 19 |
GO:003497612 | Liver | HCC | response to endoplasmic reticulum stress | 189/7958 | 256/18723 | 1.43e-24 | 4.06e-22 | 189 |
GO:003596612 | Liver | HCC | response to topologically incorrect protein | 123/7958 | 159/18723 | 2.60e-19 | 3.44e-17 | 123 |
GO:000698612 | Liver | HCC | response to unfolded protein | 103/7958 | 137/18723 | 6.50e-15 | 4.48e-13 | 103 |
GO:003596712 | Liver | HCC | cellular response to topologically incorrect protein | 89/7958 | 116/18723 | 5.61e-14 | 3.39e-12 | 89 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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