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Gene: PHF21A |
Gene summary for PHF21A |
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Gene information | Species | Human | Gene symbol | PHF21A | Gene ID | 51317 |
Gene name | PHD finger protein 21A | |
Gene Alias | BHC80 | |
Cytomap | 11p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q96BD5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51317 | PHF21A | P22T-E | Human | Esophagus | ESCC | 6.49e-16 | 2.81e-01 | 0.1236 |
51317 | PHF21A | P23T-E | Human | Esophagus | ESCC | 8.28e-04 | 1.78e-01 | 0.108 |
51317 | PHF21A | P24T-E | Human | Esophagus | ESCC | 3.18e-09 | 1.03e-01 | 0.1287 |
51317 | PHF21A | P26T-E | Human | Esophagus | ESCC | 1.49e-12 | 2.64e-01 | 0.1276 |
51317 | PHF21A | P27T-E | Human | Esophagus | ESCC | 8.12e-15 | 2.63e-01 | 0.1055 |
51317 | PHF21A | P28T-E | Human | Esophagus | ESCC | 8.67e-16 | 2.98e-01 | 0.1149 |
51317 | PHF21A | P30T-E | Human | Esophagus | ESCC | 2.78e-10 | 3.19e-01 | 0.137 |
51317 | PHF21A | P31T-E | Human | Esophagus | ESCC | 8.53e-17 | 2.87e-01 | 0.1251 |
51317 | PHF21A | P32T-E | Human | Esophagus | ESCC | 2.63e-11 | 2.57e-01 | 0.1666 |
51317 | PHF21A | P36T-E | Human | Esophagus | ESCC | 9.46e-07 | 2.83e-01 | 0.1187 |
51317 | PHF21A | P37T-E | Human | Esophagus | ESCC | 4.49e-13 | 2.76e-01 | 0.1371 |
51317 | PHF21A | P39T-E | Human | Esophagus | ESCC | 7.21e-07 | 1.37e-01 | 0.0894 |
51317 | PHF21A | P40T-E | Human | Esophagus | ESCC | 5.15e-07 | 2.81e-01 | 0.109 |
51317 | PHF21A | P42T-E | Human | Esophagus | ESCC | 1.37e-13 | 3.21e-01 | 0.1175 |
51317 | PHF21A | P47T-E | Human | Esophagus | ESCC | 2.09e-13 | 1.82e-01 | 0.1067 |
51317 | PHF21A | P48T-E | Human | Esophagus | ESCC | 6.49e-16 | 2.77e-01 | 0.0959 |
51317 | PHF21A | P49T-E | Human | Esophagus | ESCC | 1.25e-03 | 5.87e-01 | 0.1768 |
51317 | PHF21A | P52T-E | Human | Esophagus | ESCC | 1.73e-15 | 2.66e-01 | 0.1555 |
51317 | PHF21A | P54T-E | Human | Esophagus | ESCC | 3.89e-09 | 2.38e-01 | 0.0975 |
51317 | PHF21A | P56T-E | Human | Esophagus | ESCC | 3.05e-04 | 5.31e-01 | 0.1613 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00063255 | Liver | NAFLD | chromatin organization | 64/1882 | 409/18723 | 2.31e-04 | 3.89e-03 | 64 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:00063256 | Lung | IAC | chromatin organization | 69/2061 | 409/18723 | 2.01e-04 | 3.53e-03 | 69 |
GO:000632512 | Lung | AIS | chromatin organization | 62/1849 | 409/18723 | 4.24e-04 | 7.29e-03 | 62 |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
GO:000632515 | Oral cavity | EOLP | chromatin organization | 84/2218 | 409/18723 | 2.68e-07 | 8.16e-06 | 84 |
GO:000632521 | Oral cavity | NEOLP | chromatin organization | 70/2005 | 409/18723 | 4.97e-05 | 6.83e-04 | 70 |
GO:00063259 | Prostate | BPH | chromatin organization | 101/3107 | 409/18723 | 1.52e-05 | 1.94e-04 | 101 |
GO:000632514 | Prostate | Tumor | chromatin organization | 104/3246 | 409/18723 | 2.02e-05 | 2.62e-04 | 104 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHF21A | SNV | Missense_Mutation | novel | c.1907C>T | p.Ser636Phe | p.S636F | Q96BD5 | protein_coding | deleterious(0.01) | possibly_damaging(0.876) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
PHF21A | SNV | Missense_Mutation | c.985G>C | p.Glu329Gln | p.E329Q | Q96BD5 | protein_coding | tolerated(0.39) | possibly_damaging(0.836) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PHF21A | insertion | Frame_Shift_Ins | novel | c.1708_1709insCTGCTTTCTCCTCCTCACCATACCTACCCATGGCATGCAGATTT | p.Leu570ProfsTer22 | p.L570Pfs*22 | Q96BD5 | protein_coding | TCGA-B6-A0IC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PHF21A | SNV | Missense_Mutation | c.1033N>A | p.Glu345Lys | p.E345K | Q96BD5 | protein_coding | tolerated(0.33) | benign(0.023) | TCGA-DS-A0VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PHF21A | SNV | Missense_Mutation | rs149898933 | c.2012C>T | p.Ala671Val | p.A671V | Q96BD5 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-LP-A5U2-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
PHF21A | SNV | Missense_Mutation | novel | c.817N>C | p.Thr273Pro | p.T273P | Q96BD5 | protein_coding | tolerated(0.2) | benign(0) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PHF21A | SNV | Missense_Mutation | rs532473580 | c.928N>G | p.Thr310Ala | p.T310A | Q96BD5 | protein_coding | tolerated(0.3) | benign(0) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PHF21A | SNV | Missense_Mutation | rs370627435 | c.1868G>A | p.Arg623His | p.R623H | Q96BD5 | protein_coding | tolerated(0.06) | possibly_damaging(0.82) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHF21A | SNV | Missense_Mutation | novel | c.890C>T | p.Thr297Met | p.T297M | Q96BD5 | protein_coding | deleterious(0.02) | possibly_damaging(0.799) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PHF21A | SNV | Missense_Mutation | c.1508N>A | p.Cys503Tyr | p.C503Y | Q96BD5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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