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Gene: PFDN1 |
Gene summary for PFDN1 |
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Gene information | Species | Human | Gene symbol | PFDN1 | Gene ID | 5201 |
Gene name | prefoldin subunit 1 | |
Gene Alias | ||
Cytomap | 5q31.3 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | O60925 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5201 | PFDN1 | P17T-E | Human | Esophagus | ESCC | 9.39e-16 | 7.86e-01 | 0.1278 |
5201 | PFDN1 | P19T-E | Human | Esophagus | ESCC | 1.55e-10 | 8.42e-01 | 0.1662 |
5201 | PFDN1 | P20T-E | Human | Esophagus | ESCC | 3.30e-39 | 7.89e-01 | 0.1124 |
5201 | PFDN1 | P21T-E | Human | Esophagus | ESCC | 2.34e-36 | 6.87e-01 | 0.1617 |
5201 | PFDN1 | P22T-E | Human | Esophagus | ESCC | 1.05e-45 | 7.45e-01 | 0.1236 |
5201 | PFDN1 | P23T-E | Human | Esophagus | ESCC | 5.24e-32 | 6.48e-01 | 0.108 |
5201 | PFDN1 | P24T-E | Human | Esophagus | ESCC | 8.65e-30 | 5.97e-01 | 0.1287 |
5201 | PFDN1 | P26T-E | Human | Esophagus | ESCC | 7.97e-41 | 6.58e-01 | 0.1276 |
5201 | PFDN1 | P27T-E | Human | Esophagus | ESCC | 2.78e-20 | 3.81e-01 | 0.1055 |
5201 | PFDN1 | P28T-E | Human | Esophagus | ESCC | 4.81e-40 | 5.70e-01 | 0.1149 |
5201 | PFDN1 | P30T-E | Human | Esophagus | ESCC | 4.57e-23 | 7.29e-01 | 0.137 |
5201 | PFDN1 | P31T-E | Human | Esophagus | ESCC | 1.38e-21 | 3.68e-01 | 0.1251 |
5201 | PFDN1 | P32T-E | Human | Esophagus | ESCC | 6.83e-65 | 1.20e+00 | 0.1666 |
5201 | PFDN1 | P36T-E | Human | Esophagus | ESCC | 4.98e-32 | 1.07e+00 | 0.1187 |
5201 | PFDN1 | P37T-E | Human | Esophagus | ESCC | 3.98e-24 | 4.91e-01 | 0.1371 |
5201 | PFDN1 | P38T-E | Human | Esophagus | ESCC | 1.68e-15 | 7.00e-01 | 0.127 |
5201 | PFDN1 | P39T-E | Human | Esophagus | ESCC | 9.64e-17 | 2.51e-01 | 0.0894 |
5201 | PFDN1 | P40T-E | Human | Esophagus | ESCC | 5.65e-14 | 3.08e-01 | 0.109 |
5201 | PFDN1 | P42T-E | Human | Esophagus | ESCC | 2.57e-18 | 3.79e-01 | 0.1175 |
5201 | PFDN1 | P44T-E | Human | Esophagus | ESCC | 2.59e-18 | 3.10e-01 | 0.1096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
GO:190590616 | Esophagus | ESCC | regulation of amyloid fibril formation | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
GO:190590716 | Esophagus | ESCC | negative regulation of amyloid fibril formation | 11/8552 | 13/18723 | 4.76e-03 | 1.85e-02 | 11 |
GO:00064577 | Liver | Cirrhotic | protein folding | 114/4634 | 212/18723 | 9.23e-20 | 2.31e-17 | 114 |
GO:190290312 | Liver | Cirrhotic | regulation of supramolecular fiber organization | 148/4634 | 383/18723 | 8.85e-10 | 4.08e-08 | 148 |
GO:19900003 | Liver | Cirrhotic | amyloid fibril formation | 19/4634 | 34/18723 | 1.01e-04 | 1.05e-03 | 19 |
GO:1905907 | Liver | Cirrhotic | negative regulation of amyloid fibril formation | 10/4634 | 13/18723 | 1.14e-04 | 1.14e-03 | 10 |
GO:19029046 | Liver | Cirrhotic | negative regulation of supramolecular fiber organization | 63/4634 | 167/18723 | 1.29e-04 | 1.26e-03 | 63 |
GO:1905906 | Liver | Cirrhotic | regulation of amyloid fibril formation | 11/4634 | 16/18723 | 2.58e-04 | 2.30e-03 | 11 |
GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
GO:190290322 | Liver | HCC | regulation of supramolecular fiber organization | 224/7958 | 383/18723 | 1.54e-10 | 5.33e-09 | 224 |
GO:199000011 | Liver | HCC | amyloid fibril formation | 24/7958 | 34/18723 | 8.62e-04 | 5.13e-03 | 24 |
GO:190290412 | Liver | HCC | negative regulation of supramolecular fiber organization | 90/7958 | 167/18723 | 1.90e-03 | 9.69e-03 | 90 |
GO:19059071 | Liver | HCC | negative regulation of amyloid fibril formation | 11/7958 | 13/18723 | 2.38e-03 | 1.16e-02 | 11 |
GO:19059061 | Liver | HCC | regulation of amyloid fibril formation | 12/7958 | 16/18723 | 8.74e-03 | 3.40e-02 | 12 |
GO:000645718 | Oral cavity | OSCC | protein folding | 154/7305 | 212/18723 | 1.89e-23 | 4.60e-21 | 154 |
GO:190290320 | Oral cavity | OSCC | regulation of supramolecular fiber organization | 211/7305 | 383/18723 | 9.45e-11 | 2.88e-09 | 211 |
GO:19059067 | Oral cavity | OSCC | regulation of amyloid fibril formation | 13/7305 | 16/18723 | 7.05e-04 | 3.89e-03 | 13 |
GO:19059077 | Oral cavity | OSCC | negative regulation of amyloid fibril formation | 11/7305 | 13/18723 | 1.02e-03 | 5.29e-03 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PFDN1 | SNV | Missense_Mutation | c.43N>C | p.Glu15Gln | p.E15Q | O60925 | protein_coding | tolerated(0.05) | possibly_damaging(0.566) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PFDN1 | SNV | Missense_Mutation | c.185N>G | p.Glu62Gly | p.E62G | O60925 | protein_coding | deleterious(0) | possibly_damaging(0.872) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PFDN1 | SNV | Missense_Mutation | rs763185306 | c.119C>T | p.Thr40Met | p.T40M | O60925 | protein_coding | tolerated(0.09) | benign(0.081) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PFDN1 | SNV | Missense_Mutation | c.80T>C | p.Val27Ala | p.V27A | O60925 | protein_coding | tolerated(0.07) | benign(0.006) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PFDN1 | SNV | Missense_Mutation | rs757466775 | c.313N>A | p.Val105Ile | p.V105I | O60925 | protein_coding | tolerated(0.2) | benign(0.048) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PFDN1 | SNV | Missense_Mutation | novel | c.52N>T | p.Ala18Ser | p.A18S | O60925 | protein_coding | tolerated(0.34) | benign(0.062) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PFDN1 | SNV | Missense_Mutation | c.197G>T | p.Arg66Ile | p.R66I | O60925 | protein_coding | deleterious(0.02) | benign(0.376) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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