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Gene: PDZD2 |
Gene summary for PDZD2 |
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Gene information | Species | Human | Gene symbol | PDZD2 | Gene ID | 23037 |
Gene name | PDZ domain containing 2 | |
Gene Alias | AIPC | |
Cytomap | 5p13.3 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | A0A024RE15 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23037 | PDZD2 | P56T-E | Human | Esophagus | ESCC | 1.21e-03 | 7.45e-01 | 0.1613 |
23037 | PDZD2 | P57T-E | Human | Esophagus | ESCC | 2.59e-02 | 6.48e-02 | 0.0926 |
23037 | PDZD2 | P62T-E | Human | Esophagus | ESCC | 1.88e-13 | 3.28e-01 | 0.1302 |
23037 | PDZD2 | P65T-E | Human | Esophagus | ESCC | 1.90e-13 | 3.42e-01 | 0.0978 |
23037 | PDZD2 | P74T-E | Human | Esophagus | ESCC | 1.39e-08 | 3.60e-01 | 0.1479 |
23037 | PDZD2 | P75T-E | Human | Esophagus | ESCC | 9.21e-08 | 2.11e-01 | 0.1125 |
23037 | PDZD2 | P76T-E | Human | Esophagus | ESCC | 6.29e-05 | 1.88e-01 | 0.1207 |
23037 | PDZD2 | P80T-E | Human | Esophagus | ESCC | 2.24e-11 | 4.85e-01 | 0.155 |
23037 | PDZD2 | P82T-E | Human | Esophagus | ESCC | 1.47e-06 | 4.62e-01 | 0.1072 |
23037 | PDZD2 | P84T-E | Human | Esophagus | ESCC | 8.70e-09 | 8.80e-01 | 0.0933 |
23037 | PDZD2 | P89T-E | Human | Esophagus | ESCC | 1.59e-02 | 2.50e-01 | 0.1752 |
23037 | PDZD2 | P127T-E | Human | Esophagus | ESCC | 9.60e-08 | 2.53e-01 | 0.0826 |
23037 | PDZD2 | P130T-E | Human | Esophagus | ESCC | 4.23e-22 | 5.84e-01 | 0.1676 |
23037 | PDZD2 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.37e-10 | 6.15e-01 | -0.2116 |
23037 | PDZD2 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 4.40e-04 | 5.85e-01 | -0.2107 |
23037 | PDZD2 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.10e-06 | 4.94e-01 | -0.2119 |
23037 | PDZD2 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 8.15e-03 | 7.71e-01 | -0.0296 |
23037 | PDZD2 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 4.27e-03 | 6.32e-01 | -0.0263 |
23037 | PDZD2 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.73e-14 | 5.68e-01 | -0.0166 |
23037 | PDZD2 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 5.95e-18 | 5.58e-01 | -0.0132 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDZD2 | SNV | Missense_Mutation | c.7537N>A | p.Glu2513Lys | p.E2513K | O15018 | protein_coding | deleterious(0) | benign(0.265) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PDZD2 | SNV | Missense_Mutation | novel | c.5095N>T | p.Val1699Phe | p.V1699F | O15018 | protein_coding | deleterious(0.02) | benign(0.188) | TCGA-AC-A3TM-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
PDZD2 | SNV | Missense_Mutation | c.194N>G | p.Glu65Gly | p.E65G | O15018 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-AO-A0J8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
PDZD2 | SNV | Missense_Mutation | rs768167722 | c.7709G>A | p.Arg2570Lys | p.R2570K | O15018 | protein_coding | tolerated(0.16) | benign(0.071) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDZD2 | SNV | Missense_Mutation | rs372658069 | c.2435N>A | p.Arg812Gln | p.R812Q | O15018 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AR-A1AI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD |
PDZD2 | SNV | Missense_Mutation | c.4741C>T | p.Arg1581Cys | p.R1581C | O15018 | protein_coding | tolerated(0.2) | benign(0.424) | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||
PDZD2 | SNV | Missense_Mutation | rs777626634 | c.193N>A | p.Glu65Lys | p.E65K | O15018 | protein_coding | tolerated(0.08) | benign(0.223) | TCGA-BH-A0EA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | CR |
PDZD2 | SNV | Missense_Mutation | c.5855N>A | p.Arg1952Lys | p.R1952K | O15018 | protein_coding | tolerated(1) | benign(0) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
PDZD2 | SNV | Missense_Mutation | rs150231394 | c.7049N>A | p.Arg2350Gln | p.R2350Q | O15018 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
PDZD2 | SNV | Missense_Mutation | c.7294N>C | p.Glu2432Gln | p.E2432Q | O15018 | protein_coding | tolerated(0.08) | possibly_damaging(0.598) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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