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Gene: PDLIM3 |
Gene summary for PDLIM3 |
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Gene information | Species | Human | Gene symbol | PDLIM3 | Gene ID | 27295 |
Gene name | PDZ and LIM domain 3 | |
Gene Alias | ALP | |
Cytomap | 4q35.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q53GG5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27295 | PDLIM3 | P16T-E | Human | Esophagus | ESCC | 2.65e-03 | -5.98e-02 | 0.1153 |
27295 | PDLIM3 | P19T-E | Human | Esophagus | ESCC | 1.01e-03 | 2.28e+00 | 0.1662 |
27295 | PDLIM3 | P23T-E | Human | Esophagus | ESCC | 7.09e-11 | 1.03e+00 | 0.108 |
27295 | PDLIM3 | P24T-E | Human | Esophagus | ESCC | 8.29e-13 | 4.40e-01 | 0.1287 |
27295 | PDLIM3 | P26T-E | Human | Esophagus | ESCC | 1.93e-02 | 1.59e-01 | 0.1276 |
27295 | PDLIM3 | P28T-E | Human | Esophagus | ESCC | 1.14e-02 | 1.56e-01 | 0.1149 |
27295 | PDLIM3 | P32T-E | Human | Esophagus | ESCC | 5.36e-10 | 5.34e-01 | 0.1666 |
27295 | PDLIM3 | P44T-E | Human | Esophagus | ESCC | 6.49e-07 | 1.31e+00 | 0.1096 |
27295 | PDLIM3 | P47T-E | Human | Esophagus | ESCC | 3.75e-04 | 8.78e-01 | 0.1067 |
27295 | PDLIM3 | P48T-E | Human | Esophagus | ESCC | 1.01e-05 | 2.88e-01 | 0.0959 |
27295 | PDLIM3 | P49T-E | Human | Esophagus | ESCC | 9.20e-10 | 1.34e+00 | 0.1768 |
27295 | PDLIM3 | P57T-E | Human | Esophagus | ESCC | 5.49e-16 | 6.53e-01 | 0.0926 |
27295 | PDLIM3 | P65T-E | Human | Esophagus | ESCC | 4.75e-02 | 3.19e-01 | 0.0978 |
27295 | PDLIM3 | P74T-E | Human | Esophagus | ESCC | 8.00e-13 | 3.36e-01 | 0.1479 |
27295 | PDLIM3 | P76T-E | Human | Esophagus | ESCC | 1.80e-26 | 8.99e-01 | 0.1207 |
27295 | PDLIM3 | P79T-E | Human | Esophagus | ESCC | 2.46e-20 | 8.84e-01 | 0.1154 |
27295 | PDLIM3 | P107T-E | Human | Esophagus | ESCC | 4.00e-04 | 3.61e-01 | 0.171 |
27295 | PDLIM3 | P127T-E | Human | Esophagus | ESCC | 2.12e-04 | -8.06e-02 | 0.0826 |
27295 | PDLIM3 | P130T-E | Human | Esophagus | ESCC | 2.61e-78 | 2.65e+00 | 0.1676 |
27295 | PDLIM3 | HCC1_Meng | Human | Liver | HCC | 2.19e-22 | -6.80e-03 | 0.0246 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDLIM3 | SNV | Missense_Mutation | rs764191858 | c.1030N>T | p.His344Tyr | p.H344Y | Q53GG5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
PDLIM3 | SNV | Missense_Mutation | rs539118406 | c.800N>A | p.Arg267His | p.R267H | Q53GG5 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-D8-A73X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
PDLIM3 | SNV | Missense_Mutation | novel | c.812N>A | p.Thr271Lys | p.T271K | Q53GG5 | protein_coding | deleterious(0.04) | benign(0.393) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PDLIM3 | SNV | Missense_Mutation | rs747243505 | c.677N>T | p.Ser226Leu | p.S226L | Q53GG5 | protein_coding | tolerated(0.25) | benign(0.015) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDLIM3 | SNV | Missense_Mutation | c.378N>A | p.Phe126Leu | p.F126L | Q53GG5 | protein_coding | tolerated(0.05) | benign(0.442) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PDLIM3 | SNV | Missense_Mutation | c.460A>G | p.Ser154Gly | p.S154G | Q53GG5 | protein_coding | tolerated(0.12) | probably_damaging(0.952) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PDLIM3 | SNV | Missense_Mutation | rs866105307 | c.392G>A | p.Arg131Gln | p.R131Q | Q53GG5 | protein_coding | tolerated(0.6) | benign(0.007) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDLIM3 | SNV | Missense_Mutation | novel | c.283G>A | p.Asp95Asn | p.D95N | Q53GG5 | protein_coding | deleterious(0.01) | benign(0.119) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDLIM3 | SNV | Missense_Mutation | rs775988516 | c.722N>A | p.Arg241Gln | p.R241Q | Q53GG5 | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDLIM3 | SNV | Missense_Mutation | rs751951109 | c.365N>A | p.Arg122Gln | p.R122Q | Q53GG5 | protein_coding | tolerated(0.11) | possibly_damaging(0.666) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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