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Gene: PCSK7 |
Gene summary for PCSK7 |
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Gene information | Species | Human | Gene symbol | PCSK7 | Gene ID | 9159 |
Gene name | proprotein convertase subtilisin/kexin type 7 | |
Gene Alias | LPC | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q16549 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9159 | PCSK7 | A002-C-016 | Human | Colorectum | FAP | 6.63e-20 | -3.87e-01 | 0.0521 |
9159 | PCSK7 | A015-C-002 | Human | Colorectum | FAP | 3.83e-07 | -2.89e-01 | -0.0763 |
9159 | PCSK7 | A001-C-203 | Human | Colorectum | FAP | 1.14e-11 | -3.00e-01 | -0.0481 |
9159 | PCSK7 | A002-C-116 | Human | Colorectum | FAP | 1.35e-29 | -3.70e-01 | -0.0452 |
9159 | PCSK7 | A014-C-008 | Human | Colorectum | FAP | 1.98e-09 | -3.44e-01 | -0.191 |
9159 | PCSK7 | A018-E-020 | Human | Colorectum | FAP | 6.01e-14 | -2.92e-01 | -0.2034 |
9159 | PCSK7 | F034 | Human | Colorectum | FAP | 1.20e-18 | -3.27e-01 | -0.0665 |
9159 | PCSK7 | F072B | Human | Colorectum | FAP | 1.70e-12 | -3.16e-01 | 0.257 |
9159 | PCSK7 | CRC-1-8810 | Human | Colorectum | CRC | 1.77e-13 | -4.36e-01 | 0.6257 |
9159 | PCSK7 | CRC-3-11773 | Human | Colorectum | CRC | 1.35e-13 | -3.40e-01 | 0.2564 |
9159 | PCSK7 | LZE4T | Human | Esophagus | ESCC | 5.87e-07 | 2.14e-01 | 0.0811 |
9159 | PCSK7 | LZE7T | Human | Esophagus | ESCC | 1.00e-10 | 4.24e-01 | 0.0667 |
9159 | PCSK7 | LZE8T | Human | Esophagus | ESCC | 6.30e-07 | 2.27e-01 | 0.067 |
9159 | PCSK7 | LZE20T | Human | Esophagus | ESCC | 1.23e-03 | 1.70e-01 | 0.0662 |
9159 | PCSK7 | LZE24T | Human | Esophagus | ESCC | 3.79e-13 | 3.29e-01 | 0.0596 |
9159 | PCSK7 | LZE21T | Human | Esophagus | ESCC | 2.44e-06 | 2.62e-01 | 0.0655 |
9159 | PCSK7 | LZE6T | Human | Esophagus | ESCC | 1.18e-03 | 2.58e-01 | 0.0845 |
9159 | PCSK7 | P1T-E | Human | Esophagus | ESCC | 7.79e-05 | 2.93e-01 | 0.0875 |
9159 | PCSK7 | P2T-E | Human | Esophagus | ESCC | 2.96e-17 | 1.54e-01 | 0.1177 |
9159 | PCSK7 | P4T-E | Human | Esophagus | ESCC | 2.64e-18 | 4.27e-01 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
GO:0016485 | Colorectum | AD | protein processing | 63/3918 | 225/18723 | 6.77e-03 | 4.19e-02 | 63 |
GO:00516041 | Colorectum | SER | protein maturation | 73/2897 | 294/18723 | 1.82e-05 | 5.38e-04 | 73 |
GO:00164851 | Colorectum | SER | protein processing | 55/2897 | 225/18723 | 2.84e-04 | 4.67e-03 | 55 |
GO:00516042 | Colorectum | MSS | protein maturation | 75/3467 | 294/18723 | 1.70e-03 | 1.53e-02 | 75 |
GO:00164852 | Colorectum | MSS | protein processing | 57/3467 | 225/18723 | 6.60e-03 | 4.38e-02 | 57 |
GO:00516044 | Colorectum | CRC | protein maturation | 47/2078 | 294/18723 | 6.52e-03 | 4.70e-02 | 47 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:00516046 | Liver | Cirrhotic | protein maturation | 121/4634 | 294/18723 | 3.54e-10 | 1.68e-08 | 121 |
GO:00164853 | Liver | Cirrhotic | protein processing | 85/4634 | 225/18723 | 9.01e-06 | 1.32e-04 | 85 |
GO:004244511 | Liver | Cirrhotic | hormone metabolic process | 73/4634 | 218/18723 | 2.22e-03 | 1.36e-02 | 73 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:001648511 | Liver | HCC | protein processing | 121/7958 | 225/18723 | 4.01e-04 | 2.71e-03 | 121 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:00164856 | Oral cavity | OSCC | protein processing | 121/7305 | 225/18723 | 4.56e-06 | 5.23e-05 | 121 |
GO:005160416 | Oral cavity | LP | protein maturation | 122/4623 | 294/18723 | 1.37e-10 | 7.72e-09 | 122 |
GO:001648513 | Oral cavity | LP | protein processing | 83/4623 | 225/18723 | 2.87e-05 | 4.52e-04 | 83 |
GO:005160432 | Oral cavity | NEOLP | protein maturation | 50/2005 | 294/18723 | 6.46e-04 | 5.47e-03 | 50 |
GO:001648521 | Oral cavity | NEOLP | protein processing | 39/2005 | 225/18723 | 1.68e-03 | 1.17e-02 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCSK7 | SNV | Missense_Mutation | rs775499699 | c.1679N>A | p.Arg560His | p.R560H | Q16549 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCSK7 | SNV | Missense_Mutation | c.1337N>T | p.Arg446Leu | p.R446L | Q16549 | protein_coding | tolerated(0.31) | benign(0.059) | TCGA-C8-A131-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
PCSK7 | SNV | Missense_Mutation | c.133N>C | p.Asp45His | p.D45H | Q16549 | protein_coding | tolerated_low_confidence(0.11) | benign(0.037) | TCGA-DG-A2KH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PCSK7 | SNV | Missense_Mutation | c.2114N>G | p.His705Arg | p.H705R | Q16549 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-EA-A4BA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
PCSK7 | SNV | Missense_Mutation | c.1342N>C | p.Glu448Gln | p.E448Q | Q16549 | protein_coding | deleterious(0.02) | benign(0.045) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCSK7 | SNV | Missense_Mutation | c.1058N>T | p.Ala353Val | p.A353V | Q16549 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-FU-A3TX-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCSK7 | SNV | Missense_Mutation | novel | c.283N>G | p.His95Asp | p.H95D | Q16549 | protein_coding | tolerated(0.09) | possibly_damaging(0.649) | TCGA-A6-5659-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PCSK7 | SNV | Missense_Mutation | rs199777458 | c.692N>A | p.Arg231Gln | p.R231Q | Q16549 | protein_coding | deleterious(0) | probably_damaging(0.938) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PCSK7 | SNV | Missense_Mutation | c.356N>T | p.Ala119Val | p.A119V | Q16549 | protein_coding | tolerated(0.23) | benign(0.013) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PCSK7 | SNV | Missense_Mutation | c.1535N>C | p.Val512Ala | p.V512A | Q16549 | protein_coding | tolerated(0.06) | possibly_damaging(0.604) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9159 | PCSK7 | ENZYME, PROTEASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | inhibitor | 252166868 | ||
9159 | PCSK7 | ENZYME, PROTEASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | inhibitor | 252166858 |
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