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Gene: PCMTD1 |
Gene summary for PCMTD1 |
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Gene information | Species | Human | Gene symbol | PCMTD1 | Gene ID | 115294 |
Gene name | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | |
Gene Alias | PCMTD1 | |
Cytomap | 8q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | F5H1M8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
115294 | PCMTD1 | P20T-E | Human | Esophagus | ESCC | 3.29e-29 | 5.95e-01 | 0.1124 |
115294 | PCMTD1 | P21T-E | Human | Esophagus | ESCC | 3.64e-33 | 6.96e-01 | 0.1617 |
115294 | PCMTD1 | P22T-E | Human | Esophagus | ESCC | 9.24e-29 | 3.57e-01 | 0.1236 |
115294 | PCMTD1 | P23T-E | Human | Esophagus | ESCC | 2.20e-37 | 8.38e-01 | 0.108 |
115294 | PCMTD1 | P24T-E | Human | Esophagus | ESCC | 1.24e-22 | 5.78e-01 | 0.1287 |
115294 | PCMTD1 | P26T-E | Human | Esophagus | ESCC | 2.60e-34 | 5.39e-01 | 0.1276 |
115294 | PCMTD1 | P27T-E | Human | Esophagus | ESCC | 1.92e-35 | 6.85e-01 | 0.1055 |
115294 | PCMTD1 | P28T-E | Human | Esophagus | ESCC | 3.25e-29 | 6.27e-01 | 0.1149 |
115294 | PCMTD1 | P30T-E | Human | Esophagus | ESCC | 5.82e-40 | 1.28e+00 | 0.137 |
115294 | PCMTD1 | P31T-E | Human | Esophagus | ESCC | 2.42e-77 | 1.26e+00 | 0.1251 |
115294 | PCMTD1 | P32T-E | Human | Esophagus | ESCC | 1.22e-21 | 4.49e-01 | 0.1666 |
115294 | PCMTD1 | P36T-E | Human | Esophagus | ESCC | 8.13e-25 | 1.07e+00 | 0.1187 |
115294 | PCMTD1 | P37T-E | Human | Esophagus | ESCC | 1.44e-23 | 4.75e-01 | 0.1371 |
115294 | PCMTD1 | P38T-E | Human | Esophagus | ESCC | 2.88e-09 | 4.58e-01 | 0.127 |
115294 | PCMTD1 | P39T-E | Human | Esophagus | ESCC | 2.38e-20 | 3.44e-01 | 0.0894 |
115294 | PCMTD1 | P40T-E | Human | Esophagus | ESCC | 1.43e-07 | 1.90e-01 | 0.109 |
115294 | PCMTD1 | P42T-E | Human | Esophagus | ESCC | 1.07e-35 | 8.06e-01 | 0.1175 |
115294 | PCMTD1 | P44T-E | Human | Esophagus | ESCC | 5.95e-20 | 5.31e-01 | 0.1096 |
115294 | PCMTD1 | P47T-E | Human | Esophagus | ESCC | 2.26e-22 | 4.92e-01 | 0.1067 |
115294 | PCMTD1 | P48T-E | Human | Esophagus | ESCC | 2.13e-21 | 4.27e-01 | 0.0959 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:000647914 | Esophagus | ESCC | protein methylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:000821314 | Esophagus | ESCC | protein alkylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:00064791 | Liver | Cirrhotic | protein methylation | 61/4634 | 181/18723 | 4.13e-03 | 2.21e-02 | 61 |
GO:00082131 | Liver | Cirrhotic | protein alkylation | 61/4634 | 181/18723 | 4.13e-03 | 2.21e-02 | 61 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:00064792 | Liver | HCC | protein methylation | 111/7958 | 181/18723 | 2.36e-07 | 4.18e-06 | 111 |
GO:00082132 | Liver | HCC | protein alkylation | 111/7958 | 181/18723 | 2.36e-07 | 4.18e-06 | 111 |
GO:00064794 | Lung | IAC | protein methylation | 34/2061 | 181/18723 | 1.28e-03 | 1.45e-02 | 34 |
GO:00082134 | Lung | IAC | protein alkylation | 34/2061 | 181/18723 | 1.28e-03 | 1.45e-02 | 34 |
GO:000647911 | Lung | AIS | protein methylation | 29/1849 | 181/18723 | 6.16e-03 | 4.98e-02 | 29 |
GO:000821311 | Lung | AIS | protein alkylation | 29/1849 | 181/18723 | 6.16e-03 | 4.98e-02 | 29 |
GO:00064797 | Oral cavity | OSCC | protein methylation | 92/7305 | 181/18723 | 7.86e-04 | 4.26e-03 | 92 |
GO:00082137 | Oral cavity | OSCC | protein alkylation | 92/7305 | 181/18723 | 7.86e-04 | 4.26e-03 | 92 |
GO:00434142 | Oral cavity | OSCC | macromolecule methylation | 149/7305 | 316/18723 | 1.82e-03 | 8.60e-03 | 149 |
GO:00322591 | Oral cavity | OSCC | methylation | 168/7305 | 364/18723 | 3.03e-03 | 1.31e-02 | 168 |
GO:000647913 | Oral cavity | EOLP | protein methylation | 35/2218 | 181/18723 | 2.30e-03 | 1.42e-02 | 35 |
GO:000821313 | Oral cavity | EOLP | protein alkylation | 35/2218 | 181/18723 | 2.30e-03 | 1.42e-02 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCMTD1 | SNV | Missense_Mutation | c.485N>A | p.Arg162Gln | p.R162Q | Q96MG8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCMTD1 | SNV | Missense_Mutation | rs750606733 | c.274N>A | p.Gly92Arg | p.G92R | Q96MG8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCMTD1 | deletion | Frame_Shift_Del | novel | c.231delN | p.Lys77AsnfsTer18 | p.K77Nfs*18 | Q96MG8 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PCMTD1 | SNV | Missense_Mutation | c.599N>A | p.Arg200Gln | p.R200Q | Q96MG8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PCMTD1 | SNV | Missense_Mutation | c.695C>T | p.Ser232Phe | p.S232F | Q96MG8 | protein_coding | tolerated(0.34) | benign(0) | TCGA-AA-3712-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PCMTD1 | SNV | Missense_Mutation | c.668N>C | p.Ser223Thr | p.S223T | Q96MG8 | protein_coding | tolerated(0.57) | benign(0.007) | TCGA-AA-3989-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
PCMTD1 | SNV | Missense_Mutation | rs764485169 | c.755G>A | p.Arg252Gln | p.R252Q | Q96MG8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PCMTD1 | SNV | Missense_Mutation | c.19G>A | p.Ala7Thr | p.A7T | Q96MG8 | protein_coding | tolerated(0.18) | benign(0.258) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
PCMTD1 | SNV | Missense_Mutation | c.485N>A | p.Arg162Gln | p.R162Q | Q96MG8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PCMTD1 | SNV | Missense_Mutation | c.995N>C | p.Asn332Thr | p.N332T | Q96MG8 | protein_coding | tolerated(0.12) | possibly_damaging(0.493) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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