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Gene: OTUD7A |
Gene summary for OTUD7A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | OTUD7A | Gene ID | 161725 |
| Gene name | OTU deubiquitinase 7A | |
| Gene Alias | C15orf16 | |
| Cytomap | 15q13.3 | |
| Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8TE49 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 161725 | OTUD7A | A014-C-040 | Human | Colorectum | FAP | 4.64e-06 | -6.25e-01 | -0.1184 |
| 161725 | OTUD7A | A002-C-201 | Human | Colorectum | FAP | 4.82e-16 | -4.80e-01 | 0.0324 |
| 161725 | OTUD7A | A002-C-203 | Human | Colorectum | FAP | 2.40e-17 | -4.78e-01 | 0.2786 |
| 161725 | OTUD7A | A001-C-119 | Human | Colorectum | FAP | 2.47e-05 | -3.00e-01 | -0.1557 |
| 161725 | OTUD7A | A001-C-108 | Human | Colorectum | FAP | 1.20e-25 | -4.90e-01 | -0.0272 |
| 161725 | OTUD7A | A002-C-205 | Human | Colorectum | FAP | 1.70e-23 | -5.55e-01 | -0.1236 |
| 161725 | OTUD7A | A001-C-104 | Human | Colorectum | FAP | 7.82e-13 | -4.38e-01 | 0.0184 |
| 161725 | OTUD7A | A015-C-005 | Human | Colorectum | FAP | 1.72e-12 | -5.64e-01 | -0.0336 |
| 161725 | OTUD7A | A015-C-006 | Human | Colorectum | FAP | 4.02e-19 | -6.68e-01 | -0.0994 |
| 161725 | OTUD7A | A015-C-106 | Human | Colorectum | FAP | 1.60e-18 | -4.63e-01 | -0.0511 |
| 161725 | OTUD7A | A002-C-114 | Human | Colorectum | FAP | 2.91e-17 | -4.13e-01 | -0.1561 |
| 161725 | OTUD7A | A015-C-104 | Human | Colorectum | FAP | 7.28e-29 | -5.02e-01 | -0.1899 |
| 161725 | OTUD7A | A001-C-014 | Human | Colorectum | FAP | 3.74e-19 | -4.82e-01 | 0.0135 |
| 161725 | OTUD7A | A002-C-016 | Human | Colorectum | FAP | 1.71e-23 | -4.98e-01 | 0.0521 |
| 161725 | OTUD7A | A015-C-002 | Human | Colorectum | FAP | 5.86e-13 | -5.48e-01 | -0.0763 |
| 161725 | OTUD7A | A001-C-007 | Human | Colorectum | CRC | 5.51e-07 | -5.68e-01 | 0.1899 |
| 161725 | OTUD7A | A001-C-203 | Human | Colorectum | FAP | 4.49e-12 | -3.30e-01 | -0.0481 |
| 161725 | OTUD7A | A002-C-116 | Human | Colorectum | FAP | 3.20e-33 | -5.92e-01 | -0.0452 |
| 161725 | OTUD7A | A014-C-008 | Human | Colorectum | FAP | 4.34e-17 | -6.63e-01 | -0.191 |
| 161725 | OTUD7A | A018-E-020 | Human | Colorectum | FAP | 1.55e-17 | -3.84e-01 | -0.2034 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0043122 | Colorectum | AD | regulation of I-kappaB kinase/NF-kappaB signaling | 76/3918 | 249/18723 | 2.17e-04 | 2.85e-03 | 76 |
| GO:0007249 | Colorectum | AD | I-kappaB kinase/NF-kappaB signaling | 82/3918 | 281/18723 | 6.09e-04 | 6.40e-03 | 82 |
| GO:00431221 | Colorectum | MSS | regulation of I-kappaB kinase/NF-kappaB signaling | 71/3467 | 249/18723 | 7.12e-05 | 1.21e-03 | 71 |
| GO:00072491 | Colorectum | MSS | I-kappaB kinase/NF-kappaB signaling | 77/3467 | 281/18723 | 1.51e-04 | 2.19e-03 | 77 |
| GO:0071108 | Colorectum | MSS | protein K48-linked deubiquitination | 13/3467 | 35/18723 | 7.38e-03 | 4.68e-02 | 13 |
| GO:00431222 | Colorectum | FAP | regulation of I-kappaB kinase/NF-kappaB signaling | 56/2622 | 249/18723 | 1.82e-04 | 2.69e-03 | 56 |
| GO:00072492 | Colorectum | FAP | I-kappaB kinase/NF-kappaB signaling | 58/2622 | 281/18723 | 1.37e-03 | 1.24e-02 | 58 |
| GO:00431223 | Colorectum | CRC | regulation of I-kappaB kinase/NF-kappaB signaling | 41/2078 | 249/18723 | 6.39e-03 | 4.64e-02 | 41 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| OTUD7A | SNV | Missense_Mutation | c.1720G>A | p.Glu574Lys | p.E574K | Q8TE49 | protein_coding | deleterious(0.01) | benign(0.339) | TCGA-A7-A26G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
| OTUD7A | SNV | Missense_Mutation | novel | c.689N>A | p.Arg230Gln | p.R230Q | Q8TE49 | protein_coding | deleterious(0.02) | probably_damaging(0.928) | TCGA-A7-A4SA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
| OTUD7A | SNV | Missense_Mutation | novel | c.1570C>A | p.Leu524Met | p.L524M | Q8TE49 | protein_coding | tolerated(0.15) | probably_damaging(0.996) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
| OTUD7A | SNV | Missense_Mutation | c.401C>T | p.Ala134Val | p.A134V | Q8TE49 | protein_coding | deleterious(0.05) | possibly_damaging(0.612) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | |
| OTUD7A | SNV | Missense_Mutation | c.1550N>C | p.Leu517Pro | p.L517P | Q8TE49 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
| OTUD7A | insertion | In_Frame_Ins | novel | c.1008_1009insAGTTTTATTGGAACAGAG | p.Ala336_Pro337insSerPheIleGlyThrGlu | p.A336_P337insSFIGTE | Q8TE49 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| OTUD7A | SNV | Missense_Mutation | rs147009957 | c.886N>C | p.Glu296Gln | p.E296Q | Q8TE49 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| OTUD7A | SNV | Missense_Mutation | c.922G>A | p.Val308Ile | p.V308I | Q8TE49 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-WL-A834-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
| OTUD7A | insertion | Frame_Shift_Ins | novel | c.797_798insT | p.Glu266AspfsTer31 | p.E266Dfs*31 | Q8TE49 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
| OTUD7A | SNV | Missense_Mutation | c.1876N>T | p.Arg626Cys | p.R626C | Q8TE49 | protein_coding | deleterious(0) | benign(0.01) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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