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Gene: OSER1 |
Gene summary for OSER1 |
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Gene information | Species | Human | Gene symbol | OSER1 | Gene ID | 51526 |
Gene name | oxidative stress responsive serine rich 1 | |
Gene Alias | C20orf111 | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | Q9NX31 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51526 | OSER1 | P22T-E | Human | Esophagus | ESCC | 4.14e-20 | 3.49e-01 | 0.1236 |
51526 | OSER1 | P23T-E | Human | Esophagus | ESCC | 2.48e-23 | 1.02e+00 | 0.108 |
51526 | OSER1 | P24T-E | Human | Esophagus | ESCC | 1.89e-15 | 4.03e-01 | 0.1287 |
51526 | OSER1 | P26T-E | Human | Esophagus | ESCC | 2.09e-83 | 1.77e+00 | 0.1276 |
51526 | OSER1 | P27T-E | Human | Esophagus | ESCC | 1.14e-15 | 4.55e-01 | 0.1055 |
51526 | OSER1 | P28T-E | Human | Esophagus | ESCC | 2.13e-14 | 4.71e-01 | 0.1149 |
51526 | OSER1 | P30T-E | Human | Esophagus | ESCC | 5.62e-23 | 1.40e+00 | 0.137 |
51526 | OSER1 | P31T-E | Human | Esophagus | ESCC | 1.22e-46 | 1.04e+00 | 0.1251 |
51526 | OSER1 | P32T-E | Human | Esophagus | ESCC | 1.03e-13 | 4.56e-01 | 0.1666 |
51526 | OSER1 | P36T-E | Human | Esophagus | ESCC | 2.04e-10 | 6.65e-01 | 0.1187 |
51526 | OSER1 | P37T-E | Human | Esophagus | ESCC | 9.62e-15 | 3.03e-01 | 0.1371 |
51526 | OSER1 | P39T-E | Human | Esophagus | ESCC | 1.55e-19 | 5.57e-01 | 0.0894 |
51526 | OSER1 | P40T-E | Human | Esophagus | ESCC | 1.57e-10 | 2.95e-01 | 0.109 |
51526 | OSER1 | P42T-E | Human | Esophagus | ESCC | 5.88e-14 | 5.16e-01 | 0.1175 |
51526 | OSER1 | P44T-E | Human | Esophagus | ESCC | 1.86e-06 | 1.18e-01 | 0.1096 |
51526 | OSER1 | P47T-E | Human | Esophagus | ESCC | 1.06e-32 | 8.68e-01 | 0.1067 |
51526 | OSER1 | P48T-E | Human | Esophagus | ESCC | 3.67e-20 | 5.83e-01 | 0.0959 |
51526 | OSER1 | P49T-E | Human | Esophagus | ESCC | 6.78e-13 | 1.42e+00 | 0.1768 |
51526 | OSER1 | P52T-E | Human | Esophagus | ESCC | 2.08e-17 | 9.13e-01 | 0.1555 |
51526 | OSER1 | P54T-E | Human | Esophagus | ESCC | 4.43e-18 | 8.09e-01 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:0000302111 | Esophagus | ESCC | response to reactive oxygen species | 150/8552 | 222/18723 | 3.06e-11 | 1.02e-09 | 150 |
GO:0042542111 | Esophagus | ESCC | response to hydrogen peroxide | 102/8552 | 146/18723 | 2.64e-09 | 5.81e-08 | 102 |
GO:003461420 | Esophagus | ESCC | cellular response to reactive oxygen species | 103/8552 | 155/18723 | 1.34e-07 | 2.17e-06 | 103 |
GO:00703018 | Esophagus | ESCC | cellular response to hydrogen peroxide | 68/8552 | 98/18723 | 1.70e-06 | 2.03e-05 | 68 |
GO:000697912 | Liver | Cirrhotic | response to oxidative stress | 196/4634 | 446/18723 | 2.80e-19 | 5.86e-17 | 196 |
GO:006219712 | Liver | Cirrhotic | cellular response to chemical stress | 147/4634 | 337/18723 | 1.84e-14 | 1.72e-12 | 147 |
GO:003459912 | Liver | Cirrhotic | cellular response to oxidative stress | 127/4634 | 288/18723 | 4.29e-13 | 3.32e-11 | 127 |
GO:000030212 | Liver | Cirrhotic | response to reactive oxygen species | 100/4634 | 222/18723 | 2.92e-11 | 1.73e-09 | 100 |
GO:004254212 | Liver | Cirrhotic | response to hydrogen peroxide | 71/4634 | 146/18723 | 3.40e-10 | 1.63e-08 | 71 |
GO:00346147 | Liver | Cirrhotic | cellular response to reactive oxygen species | 70/4634 | 155/18723 | 2.27e-08 | 7.91e-07 | 70 |
GO:00703012 | Liver | Cirrhotic | cellular response to hydrogen peroxide | 46/4634 | 98/18723 | 1.49e-06 | 2.93e-05 | 46 |
GO:000697922 | Liver | HCC | response to oxidative stress | 281/7958 | 446/18723 | 9.75e-19 | 1.24e-16 | 281 |
GO:006219722 | Liver | HCC | cellular response to chemical stress | 216/7958 | 337/18723 | 6.86e-16 | 5.44e-14 | 216 |
GO:003459922 | Liver | HCC | cellular response to oxidative stress | 183/7958 | 288/18723 | 3.65e-13 | 1.93e-11 | 183 |
GO:000030222 | Liver | HCC | response to reactive oxygen species | 144/7958 | 222/18723 | 1.24e-11 | 5.09e-10 | 144 |
GO:004254222 | Liver | HCC | response to hydrogen peroxide | 100/7958 | 146/18723 | 1.79e-10 | 6.15e-09 | 100 |
GO:003461412 | Liver | HCC | cellular response to reactive oxygen species | 102/7958 | 155/18723 | 3.70e-09 | 9.89e-08 | 102 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OSER1 | SNV | Missense_Mutation | c.180N>A | p.Asp60Glu | p.D60E | Q9NX31 | protein_coding | tolerated(1) | benign(0.068) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
OSER1 | SNV | Missense_Mutation | rs781381485 | c.719N>T | p.Ser240Leu | p.S240L | Q9NX31 | protein_coding | tolerated(0.08) | benign(0.062) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
OSER1 | SNV | Missense_Mutation | rs373020907 | c.235N>T | p.Arg79Cys | p.R79C | Q9NX31 | protein_coding | tolerated(0.07) | probably_damaging(0.968) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
OSER1 | SNV | Missense_Mutation | c.145N>T | p.Asp49Tyr | p.D49Y | Q9NX31 | protein_coding | deleterious(0.03) | probably_damaging(0.916) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
OSER1 | SNV | Missense_Mutation | rs777251819 | c.415G>A | p.Asp139Asn | p.D139N | Q9NX31 | protein_coding | tolerated(0.12) | benign(0.027) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OSER1 | SNV | Missense_Mutation | c.226N>G | p.Thr76Ala | p.T76A | Q9NX31 | protein_coding | deleterious(0.02) | possibly_damaging(0.492) | TCGA-AG-3728-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | CR | |
OSER1 | SNV | Missense_Mutation | novel | c.633N>A | p.Asp211Glu | p.D211E | Q9NX31 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OSER1 | SNV | Missense_Mutation | novel | c.773G>A | p.Arg258Gln | p.R258Q | Q9NX31 | protein_coding | deleterious(0.03) | benign(0.116) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
OSER1 | SNV | Missense_Mutation | c.639N>C | p.Glu213Asp | p.E213D | Q9NX31 | protein_coding | deleterious(0.01) | probably_damaging(0.912) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
OSER1 | SNV | Missense_Mutation | c.217G>A | p.Ala73Thr | p.A73T | Q9NX31 | protein_coding | tolerated(0.35) | benign(0.01) | TCGA-AP-A0LD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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