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Gene: OSBPL10 |
Gene summary for OSBPL10 |
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Gene information | Species | Human | Gene symbol | OSBPL10 | Gene ID | 114884 |
Gene name | oxysterol binding protein like 10 | |
Gene Alias | ORP10 | |
Cytomap | 3p23 | |
Gene Type | protein-coding | GO ID | GO:0006575 | UniProtAcc | Q9BXB5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114884 | OSBPL10 | A014-C-008 | Human | Colorectum | FAP | 5.46e-10 | -3.95e-01 | -0.191 |
114884 | OSBPL10 | A018-E-020 | Human | Colorectum | FAP | 2.22e-17 | -4.79e-01 | -0.2034 |
114884 | OSBPL10 | F034 | Human | Colorectum | FAP | 4.35e-08 | -2.31e-01 | -0.0665 |
114884 | OSBPL10 | AEH-subject1 | Human | Endometrium | AEH | 3.05e-16 | 3.96e-01 | -0.3059 |
114884 | OSBPL10 | AEH-subject2 | Human | Endometrium | AEH | 1.82e-12 | 4.56e-01 | -0.2525 |
114884 | OSBPL10 | AEH-subject3 | Human | Endometrium | AEH | 4.32e-05 | 2.69e-01 | -0.2576 |
114884 | OSBPL10 | AEH-subject4 | Human | Endometrium | AEH | 1.43e-06 | 3.66e-01 | -0.2657 |
114884 | OSBPL10 | AEH-subject5 | Human | Endometrium | AEH | 2.60e-05 | 2.53e-01 | -0.2953 |
114884 | OSBPL10 | EEC-subject1 | Human | Endometrium | EEC | 3.78e-09 | 3.73e-01 | -0.2682 |
114884 | OSBPL10 | EEC-subject2 | Human | Endometrium | EEC | 8.17e-20 | 4.85e-01 | -0.2607 |
114884 | OSBPL10 | EEC-subject3 | Human | Endometrium | EEC | 3.04e-10 | 4.38e-01 | -0.2525 |
114884 | OSBPL10 | EEC-subject4 | Human | Endometrium | EEC | 1.30e-04 | 2.36e-01 | -0.2571 |
114884 | OSBPL10 | EEC-subject5 | Human | Endometrium | EEC | 6.88e-35 | 7.70e-01 | -0.249 |
114884 | OSBPL10 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.70e-05 | 1.24e-01 | -0.1869 |
114884 | OSBPL10 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.51e-02 | 3.13e-02 | -0.1875 |
114884 | OSBPL10 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 3.28e-06 | 8.92e-02 | -0.1883 |
114884 | OSBPL10 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.22e-06 | 9.29e-02 | -0.1916 |
114884 | OSBPL10 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 9.43e-04 | 3.17e-01 | -0.2116 |
114884 | OSBPL10 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.37e-05 | 5.94e-01 | -0.2119 |
114884 | OSBPL10 | RNA-P3T-P3T-1 | Human | Lung | IAC | 3.77e-06 | 7.40e-01 | 0.1829 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006575 | Colorectum | AD | cellular modified amino acid metabolic process | 59/3918 | 188/18723 | 4.80e-04 | 5.27e-03 | 59 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:00068691 | Colorectum | FAP | lipid transport | 81/2622 | 398/18723 | 2.84e-04 | 3.76e-03 | 81 |
GO:00066502 | Colorectum | FAP | glycerophospholipid metabolic process | 62/2622 | 306/18723 | 1.54e-03 | 1.38e-02 | 62 |
GO:00108762 | Colorectum | FAP | lipid localization | 85/2622 | 448/18723 | 1.92e-03 | 1.63e-02 | 85 |
GO:00066442 | Colorectum | FAP | phospholipid metabolic process | 74/2622 | 383/18723 | 2.24e-03 | 1.83e-02 | 74 |
GO:0006658 | Colorectum | FAP | phosphatidylserine metabolic process | 9/2622 | 25/18723 | 5.01e-03 | 3.33e-02 | 9 |
GO:0015914 | Colorectum | FAP | phospholipid transport | 23/2622 | 96/18723 | 6.09e-03 | 3.82e-02 | 23 |
GO:00159142 | Lung | IAC | phospholipid transport | 20/2061 | 96/18723 | 3.58e-03 | 3.00e-02 | 20 |
GO:00157482 | Lung | IAC | organophosphate ester transport | 26/2061 | 140/18723 | 5.22e-03 | 3.97e-02 | 26 |
GO:001591411 | Lung | AIS | phospholipid transport | 18/1849 | 96/18723 | 5.64e-03 | 4.76e-02 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OSBPL10 | SNV | Missense_Mutation | novel | c.396C>A | p.Ser132Arg | p.S132R | Q9BXB5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A1G1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OSBPL10 | SNV | Missense_Mutation | c.1387N>T | p.Leu463Phe | p.L463F | Q9BXB5 | protein_coding | deleterious(0) | possibly_damaging(0.888) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
OSBPL10 | SNV | Missense_Mutation | rs780338081 | c.560N>A | p.Arg187Gln | p.R187Q | Q9BXB5 | protein_coding | deleterious(0.01) | possibly_damaging(0.897) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OSBPL10 | SNV | Missense_Mutation | c.1798C>G | p.Leu600Val | p.L600V | Q9BXB5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
OSBPL10 | SNV | Missense_Mutation | c.1361G>C | p.Arg454Thr | p.R454T | Q9BXB5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
OSBPL10 | SNV | Missense_Mutation | rs267599767 | c.500N>A | p.Arg167Gln | p.R167Q | Q9BXB5 | protein_coding | tolerated(0.97) | benign(0.075) | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
OSBPL10 | SNV | Missense_Mutation | c.1550N>T | p.Ala517Val | p.A517V | Q9BXB5 | protein_coding | tolerated(0.15) | benign(0.026) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
OSBPL10 | SNV | Missense_Mutation | rs74657729 | c.1277N>A | p.Arg426Gln | p.R426Q | Q9BXB5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OSBPL10 | SNV | Missense_Mutation | c.718N>A | p.Glu240Lys | p.E240K | Q9BXB5 | protein_coding | tolerated(0.07) | possibly_damaging(0.728) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
OSBPL10 | SNV | Missense_Mutation | rs140782910 | c.1537G>A | p.Glu513Lys | p.E513K | Q9BXB5 | protein_coding | tolerated(0.37) | benign(0.014) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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