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Gene: OGFR |
Gene summary for OGFR |
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Gene information | Species | Human | Gene symbol | OGFR | Gene ID | 11054 |
Gene name | opioid growth factor receptor | |
Gene Alias | OGFR | |
Cytomap | 20q13.33 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | Q9NZT2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11054 | OGFR | P21T-E | Human | Esophagus | ESCC | 6.25e-46 | 7.49e-01 | 0.1617 |
11054 | OGFR | P22T-E | Human | Esophagus | ESCC | 2.01e-26 | 4.88e-01 | 0.1236 |
11054 | OGFR | P23T-E | Human | Esophagus | ESCC | 1.54e-39 | 8.34e-01 | 0.108 |
11054 | OGFR | P24T-E | Human | Esophagus | ESCC | 5.49e-41 | 8.47e-01 | 0.1287 |
11054 | OGFR | P26T-E | Human | Esophagus | ESCC | 5.00e-47 | 7.24e-01 | 0.1276 |
11054 | OGFR | P27T-E | Human | Esophagus | ESCC | 2.37e-17 | 3.55e-01 | 0.1055 |
11054 | OGFR | P28T-E | Human | Esophagus | ESCC | 1.10e-35 | 7.51e-01 | 0.1149 |
11054 | OGFR | P30T-E | Human | Esophagus | ESCC | 1.90e-21 | 6.97e-01 | 0.137 |
11054 | OGFR | P31T-E | Human | Esophagus | ESCC | 4.34e-47 | 8.99e-01 | 0.1251 |
11054 | OGFR | P32T-E | Human | Esophagus | ESCC | 4.24e-32 | 6.04e-01 | 0.1666 |
11054 | OGFR | P36T-E | Human | Esophagus | ESCC | 3.27e-29 | 9.38e-01 | 0.1187 |
11054 | OGFR | P37T-E | Human | Esophagus | ESCC | 8.24e-24 | 4.22e-01 | 0.1371 |
11054 | OGFR | P38T-E | Human | Esophagus | ESCC | 6.58e-04 | 2.23e-01 | 0.127 |
11054 | OGFR | P39T-E | Human | Esophagus | ESCC | 3.02e-23 | 3.58e-01 | 0.0894 |
11054 | OGFR | P40T-E | Human | Esophagus | ESCC | 9.58e-16 | 4.63e-01 | 0.109 |
11054 | OGFR | P42T-E | Human | Esophagus | ESCC | 3.15e-18 | 4.89e-01 | 0.1175 |
11054 | OGFR | P44T-E | Human | Esophagus | ESCC | 8.12e-11 | 3.05e-01 | 0.1096 |
11054 | OGFR | P47T-E | Human | Esophagus | ESCC | 8.23e-27 | 5.50e-01 | 0.1067 |
11054 | OGFR | P48T-E | Human | Esophagus | ESCC | 2.55e-21 | 4.77e-01 | 0.0959 |
11054 | OGFR | P49T-E | Human | Esophagus | ESCC | 3.02e-17 | 1.48e+00 | 0.1768 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604919 | Esophagus | HGIN | cell growth | 93/2587 | 482/18723 | 4.49e-04 | 6.62e-03 | 93 |
GO:000155818 | Esophagus | HGIN | regulation of cell growth | 76/2587 | 414/18723 | 5.40e-03 | 4.42e-02 | 76 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:001604911 | Liver | Cirrhotic | cell growth | 160/4634 | 482/18723 | 1.50e-05 | 2.07e-04 | 160 |
GO:000155811 | Liver | Cirrhotic | regulation of cell growth | 132/4634 | 414/18723 | 5.53e-04 | 4.36e-03 | 132 |
GO:001604921 | Liver | HCC | cell growth | 269/7958 | 482/18723 | 1.84e-09 | 5.35e-08 | 269 |
GO:000155821 | Liver | HCC | regulation of cell growth | 228/7958 | 414/18723 | 1.34e-07 | 2.55e-06 | 228 |
GO:001604917 | Oral cavity | OSCC | cell growth | 268/7305 | 482/18723 | 6.55e-14 | 3.51e-12 | 268 |
GO:000155816 | Oral cavity | OSCC | regulation of cell growth | 228/7305 | 414/18723 | 1.74e-11 | 6.09e-10 | 228 |
GO:001604918 | Oral cavity | LP | cell growth | 155/4623 | 482/18723 | 1.08e-04 | 1.31e-03 | 155 |
GO:000155817 | Oral cavity | LP | regulation of cell growth | 134/4623 | 414/18723 | 2.25e-04 | 2.41e-03 | 134 |
GO:001604925 | Skin | cSCC | cell growth | 173/4864 | 482/18723 | 7.21e-07 | 1.34e-05 | 173 |
GO:000155824 | Skin | cSCC | regulation of cell growth | 140/4864 | 414/18723 | 2.07e-04 | 1.72e-03 | 140 |
GO:0016049112 | Thyroid | PTC | cell growth | 225/5968 | 482/18723 | 4.75e-12 | 2.07e-10 | 225 |
GO:0001558111 | Thyroid | PTC | regulation of cell growth | 188/5968 | 414/18723 | 4.13e-09 | 1.09e-07 | 188 |
GO:001604927 | Thyroid | ATC | cell growth | 241/6293 | 482/18723 | 4.27e-14 | 2.35e-12 | 241 |
GO:000155826 | Thyroid | ATC | regulation of cell growth | 201/6293 | 414/18723 | 1.57e-10 | 4.76e-09 | 201 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OGFR | deletion | Frame_Shift_Del | novel | c.276delN | p.Asn93ThrfsTer2 | p.N93Tfs*2 | Q9NZT2 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
OGFR | SNV | Missense_Mutation | rs774947493 | c.877N>T | p.Arg293Trp | p.R293W | Q9NZT2 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
OGFR | SNV | Missense_Mutation | rs749941602 | c.1409N>T | p.Ala470Val | p.A470V | Q9NZT2 | protein_coding | tolerated(0.53) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
OGFR | SNV | Missense_Mutation | c.799C>T | p.Arg267Cys | p.R267C | Q9NZT2 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AA-3496-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OGFR | SNV | Missense_Mutation | rs564432812 | c.1231G>A | p.Ala411Thr | p.A411T | Q9NZT2 | protein_coding | deleterious(0) | possibly_damaging(0.484) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
OGFR | SNV | Missense_Mutation | c.980N>A | p.Gly327Asp | p.G327D | Q9NZT2 | protein_coding | tolerated(0.14) | possibly_damaging(0.673) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
OGFR | SNV | Missense_Mutation | rs777605843 | c.731G>A | p.Arg244Gln | p.R244Q | Q9NZT2 | protein_coding | tolerated(0.6) | benign(0.001) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OGFR | SNV | Missense_Mutation | rs373078338 | c.964G>A | p.Glu322Lys | p.E322K | Q9NZT2 | protein_coding | tolerated(0.34) | benign(0.001) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
OGFR | deletion | Frame_Shift_Del | c.1971delN | p.Glu659ArgfsTer55 | p.E659Rfs*55 | Q9NZT2 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
OGFR | SNV | Missense_Mutation | novel | c.1921N>G | p.Thr641Ala | p.T641A | Q9NZT2 | protein_coding | deleterious_low_confidence(0.03) | benign(0.056) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11054 | OGFR | NA | INNO-105 | |||
11054 | OGFR | NA | IRT-102 |
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