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Gene: OAT |
Gene summary for OAT |
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Gene information | Species | Human | Gene symbol | OAT | Gene ID | 4942 |
Gene name | ornithine aminotransferase | |
Gene Alias | GACR | |
Cytomap | 10q26.13 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A0A140VJQ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4942 | OAT | HTA11_347_2000001011 | Human | Colorectum | AD | 7.57e-11 | 4.75e-01 | -0.1954 |
4942 | OAT | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.40e-06 | 5.38e-01 | -0.059 |
4942 | OAT | HTA11_7862_2000001011 | Human | Colorectum | AD | 8.23e-07 | 6.85e-01 | -0.0179 |
4942 | OAT | HTA11_866_3004761011 | Human | Colorectum | AD | 7.64e-06 | 4.62e-01 | 0.096 |
4942 | OAT | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.03e-05 | 7.59e-01 | 0.0131 |
4942 | OAT | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.75e-04 | 7.13e-01 | 0.0171 |
4942 | OAT | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.15e-13 | 5.92e-01 | 0.294 |
4942 | OAT | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.37e-03 | 1.30e+00 | 0.3487 |
4942 | OAT | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.33e-23 | 9.58e-01 | 0.3859 |
4942 | OAT | A018-E-020 | Human | Colorectum | FAP | 1.04e-02 | -1.10e-01 | -0.2034 |
4942 | OAT | LZE4T | Human | Esophagus | ESCC | 2.52e-06 | 6.66e-01 | 0.0811 |
4942 | OAT | LZE8T | Human | Esophagus | ESCC | 7.66e-04 | 1.01e-01 | 0.067 |
4942 | OAT | LZE20T | Human | Esophagus | ESCC | 8.75e-04 | 4.51e-02 | 0.0662 |
4942 | OAT | LZE24T | Human | Esophagus | ESCC | 6.14e-09 | 8.66e-01 | 0.0596 |
4942 | OAT | LZE21T | Human | Esophagus | ESCC | 7.02e-04 | -1.21e-02 | 0.0655 |
4942 | OAT | P2T-E | Human | Esophagus | ESCC | 2.07e-41 | 1.05e+00 | 0.1177 |
4942 | OAT | P4T-E | Human | Esophagus | ESCC | 3.02e-42 | 1.39e+00 | 0.1323 |
4942 | OAT | P5T-E | Human | Esophagus | ESCC | 3.53e-13 | 6.19e-01 | 0.1327 |
4942 | OAT | P8T-E | Human | Esophagus | ESCC | 3.63e-31 | 8.62e-01 | 0.0889 |
4942 | OAT | P9T-E | Human | Esophagus | ESCC | 3.94e-08 | 4.35e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00463946 | Breast | Precancer | carboxylic acid biosynthetic process | 32/1080 | 314/18723 | 1.30e-03 | 1.38e-02 | 32 |
GO:00160536 | Breast | Precancer | organic acid biosynthetic process | 32/1080 | 316/18723 | 1.44e-03 | 1.50e-02 | 32 |
GO:001605313 | Breast | IDC | organic acid biosynthetic process | 39/1434 | 316/18723 | 2.13e-03 | 1.99e-02 | 39 |
GO:004639413 | Breast | IDC | carboxylic acid biosynthetic process | 38/1434 | 314/18723 | 3.39e-03 | 2.83e-02 | 38 |
GO:001605322 | Breast | DCIS | organic acid biosynthetic process | 38/1390 | 316/18723 | 2.22e-03 | 2.04e-02 | 38 |
GO:004639422 | Breast | DCIS | carboxylic acid biosynthetic process | 37/1390 | 314/18723 | 3.56e-03 | 2.92e-02 | 37 |
GO:00065755 | Cervix | HSIL_HPV | cellular modified amino acid metabolic process | 16/737 | 188/18723 | 3.18e-03 | 2.89e-02 | 16 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0030258 | Colorectum | AD | lipid modification | 67/3918 | 212/18723 | 1.66e-04 | 2.27e-03 | 67 |
GO:0016054 | Colorectum | AD | organic acid catabolic process | 73/3918 | 240/18723 | 3.20e-04 | 3.81e-03 | 73 |
GO:0006575 | Colorectum | AD | cellular modified amino acid metabolic process | 59/3918 | 188/18723 | 4.80e-04 | 5.27e-03 | 59 |
GO:0043648 | Colorectum | AD | dicarboxylic acid metabolic process | 34/3918 | 96/18723 | 7.22e-04 | 7.28e-03 | 34 |
GO:0046395 | Colorectum | AD | carboxylic acid catabolic process | 70/3918 | 236/18723 | 9.06e-04 | 8.71e-03 | 70 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:00442821 | Colorectum | SER | small molecule catabolic process | 87/2897 | 376/18723 | 5.31e-05 | 1.27e-03 | 87 |
GO:0046486 | Colorectum | SER | glycerolipid metabolic process | 82/2897 | 392/18723 | 2.26e-03 | 2.17e-02 | 82 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00330 | Colorectum | AD | Arginine and proline metabolism | 23/2092 | 50/8465 | 8.27e-04 | 5.90e-03 | 3.76e-03 | 23 |
hsa003301 | Colorectum | AD | Arginine and proline metabolism | 23/2092 | 50/8465 | 8.27e-04 | 5.90e-03 | 3.76e-03 | 23 |
hsa003302 | Colorectum | SER | Arginine and proline metabolism | 17/1580 | 50/8465 | 7.12e-03 | 3.77e-02 | 2.74e-02 | 17 |
hsa003303 | Colorectum | SER | Arginine and proline metabolism | 17/1580 | 50/8465 | 7.12e-03 | 3.77e-02 | 2.74e-02 | 17 |
hsa003304 | Colorectum | MSS | Arginine and proline metabolism | 23/1875 | 50/8465 | 1.52e-04 | 1.24e-03 | 7.61e-04 | 23 |
hsa003305 | Colorectum | MSS | Arginine and proline metabolism | 23/1875 | 50/8465 | 1.52e-04 | 1.24e-03 | 7.61e-04 | 23 |
hsa0033021 | Liver | HCC | Arginine and proline metabolism | 33/4020 | 50/8465 | 6.28e-03 | 1.77e-02 | 9.83e-03 | 33 |
hsa0033031 | Liver | HCC | Arginine and proline metabolism | 33/4020 | 50/8465 | 6.28e-03 | 1.77e-02 | 9.83e-03 | 33 |
hsa0033010 | Oral cavity | OSCC | Arginine and proline metabolism | 30/3704 | 50/8465 | 1.50e-02 | 3.26e-02 | 1.66e-02 | 30 |
hsa0033013 | Oral cavity | OSCC | Arginine and proline metabolism | 30/3704 | 50/8465 | 1.50e-02 | 3.26e-02 | 1.66e-02 | 30 |
hsa0033023 | Oral cavity | LP | Arginine and proline metabolism | 26/2418 | 50/8465 | 3.94e-04 | 2.08e-03 | 1.34e-03 | 26 |
hsa0033033 | Oral cavity | LP | Arginine and proline metabolism | 26/2418 | 50/8465 | 3.94e-04 | 2.08e-03 | 1.34e-03 | 26 |
hsa003309 | Prostate | BPH | Arginine and proline metabolism | 18/1718 | 50/8465 | 7.17e-03 | 2.32e-02 | 1.43e-02 | 18 |
hsa0033012 | Prostate | BPH | Arginine and proline metabolism | 18/1718 | 50/8465 | 7.17e-03 | 2.32e-02 | 1.43e-02 | 18 |
hsa0033022 | Prostate | Tumor | Arginine and proline metabolism | 19/1791 | 50/8465 | 4.73e-03 | 1.67e-02 | 1.03e-02 | 19 |
hsa0033032 | Prostate | Tumor | Arginine and proline metabolism | 19/1791 | 50/8465 | 4.73e-03 | 1.67e-02 | 1.03e-02 | 19 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OAT | SNV | Missense_Mutation | novel | c.310C>G | p.Gln104Glu | p.Q104E | P04181 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A3QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OAT | SNV | Missense_Mutation | novel | c.989N>A | p.Cys330Tyr | p.C330Y | P04181 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-PE-A5DC-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
OAT | insertion | In_Frame_Ins | novel | c.842_843insTTGTTT | p.Glu281delinsAspCysLeu | p.E281delinsDCL | P04181 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
OAT | deletion | Frame_Shift_Del | novel | c.841delN | p.Glu281LysfsTer7 | p.E281Kfs*7 | P04181 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
OAT | SNV | Missense_Mutation | rs763064048 | c.1111G>A | p.Val371Ile | p.V371I | P04181 | protein_coding | tolerated(0.11) | benign(0.101) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
OAT | SNV | Missense_Mutation | rs121965054 | c.1180T>C | p.Cys394Arg | p.C394R | P04181 | protein_coding | tolerated(0.06) | benign(0.291) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
OAT | SNV | Missense_Mutation | rs121965044 | c.1250N>T | p.Pro417Leu | p.P417L | P04181 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
OAT | SNV | Missense_Mutation | c.1022N>G | p.Glu341Gly | p.E341G | P04181 | protein_coding | tolerated(0.13) | benign(0.38) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
OAT | SNV | Missense_Mutation | novel | c.965N>T | p.Thr322Ile | p.T322I | P04181 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OAT | SNV | Missense_Mutation | rs1804030 | c.460N>T | p.Arg154Cys | p.R154C | P04181 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4942 | OAT | ENZYME, DRUGGABLE GENOME | GABACULINE | GABACULINE | 26288681 |
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