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Gene: NUTM2B-AS1 |
Gene summary for NUTM2B-AS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NUTM2B-AS1 | Gene ID | 101060691 |
Gene name | NUTM2B antisense RNA 1 | |
Gene Alias | OPML1 | |
Cytomap | 10q22.3 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
101060691 | NUTM2B-AS1 | F007 | Human | Colorectum | FAP | 4.00e-08 | -5.82e-01 | 0.1176 |
101060691 | NUTM2B-AS1 | A001-C-207 | Human | Colorectum | FAP | 3.26e-06 | -3.55e-01 | 0.1278 |
101060691 | NUTM2B-AS1 | A015-C-203 | Human | Colorectum | FAP | 8.75e-42 | -7.96e-01 | -0.1294 |
101060691 | NUTM2B-AS1 | A015-C-204 | Human | Colorectum | FAP | 1.36e-13 | -5.79e-01 | -0.0228 |
101060691 | NUTM2B-AS1 | A014-C-040 | Human | Colorectum | FAP | 4.42e-08 | -7.04e-01 | -0.1184 |
101060691 | NUTM2B-AS1 | A002-C-201 | Human | Colorectum | FAP | 1.70e-21 | -5.57e-01 | 0.0324 |
101060691 | NUTM2B-AS1 | A002-C-203 | Human | Colorectum | FAP | 1.07e-07 | -2.24e-01 | 0.2786 |
101060691 | NUTM2B-AS1 | A001-C-119 | Human | Colorectum | FAP | 6.29e-17 | -7.34e-01 | -0.1557 |
101060691 | NUTM2B-AS1 | A001-C-108 | Human | Colorectum | FAP | 2.97e-26 | -5.39e-01 | -0.0272 |
101060691 | NUTM2B-AS1 | A002-C-205 | Human | Colorectum | FAP | 1.47e-30 | -6.92e-01 | -0.1236 |
101060691 | NUTM2B-AS1 | A014-C-108 | Human | Colorectum | FAP | 8.32e-04 | -4.67e-01 | -0.124 |
101060691 | NUTM2B-AS1 | A001-C-104 | Human | Colorectum | FAP | 9.04e-07 | -3.87e-01 | 0.0184 |
101060691 | NUTM2B-AS1 | A015-C-005 | Human | Colorectum | FAP | 1.56e-17 | -6.02e-01 | -0.0336 |
101060691 | NUTM2B-AS1 | A015-C-006 | Human | Colorectum | FAP | 2.54e-27 | -8.18e-01 | -0.0994 |
101060691 | NUTM2B-AS1 | A015-C-106 | Human | Colorectum | FAP | 6.97e-27 | -6.53e-01 | -0.0511 |
101060691 | NUTM2B-AS1 | A002-C-114 | Human | Colorectum | FAP | 4.31e-25 | -6.15e-01 | -0.1561 |
101060691 | NUTM2B-AS1 | A015-C-104 | Human | Colorectum | FAP | 9.74e-40 | -7.65e-01 | -0.1899 |
101060691 | NUTM2B-AS1 | A001-C-014 | Human | Colorectum | FAP | 1.26e-23 | -5.20e-01 | 0.0135 |
101060691 | NUTM2B-AS1 | A002-C-016 | Human | Colorectum | FAP | 2.22e-28 | -4.92e-01 | 0.0521 |
101060691 | NUTM2B-AS1 | A015-C-002 | Human | Colorectum | FAP | 1.13e-18 | -6.84e-01 | -0.0763 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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