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Gene: NUTM2A-AS1 |
Gene summary for NUTM2A-AS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NUTM2A-AS1 | Gene ID | 728190 |
Gene name | NUTM2A antisense RNA 1 | |
Gene Alias | FAM22A-AS1 | |
Cytomap | 10q23.2 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
728190 | NUTM2A-AS1 | A001-C-119 | Human | Colorectum | FAP | 3.56e-25 | -7.99e-01 | -0.1557 |
728190 | NUTM2A-AS1 | A001-C-108 | Human | Colorectum | FAP | 4.41e-20 | -4.85e-01 | -0.0272 |
728190 | NUTM2A-AS1 | A002-C-205 | Human | Colorectum | FAP | 2.28e-32 | -6.73e-01 | -0.1236 |
728190 | NUTM2A-AS1 | A001-C-104 | Human | Colorectum | FAP | 3.98e-04 | -3.54e-01 | 0.0184 |
728190 | NUTM2A-AS1 | A015-C-005 | Human | Colorectum | FAP | 6.95e-12 | -4.99e-01 | -0.0336 |
728190 | NUTM2A-AS1 | A015-C-006 | Human | Colorectum | FAP | 5.25e-21 | -6.50e-01 | -0.0994 |
728190 | NUTM2A-AS1 | A015-C-106 | Human | Colorectum | FAP | 3.43e-17 | -4.68e-01 | -0.0511 |
728190 | NUTM2A-AS1 | A002-C-114 | Human | Colorectum | FAP | 2.00e-25 | -6.21e-01 | -0.1561 |
728190 | NUTM2A-AS1 | A015-C-104 | Human | Colorectum | FAP | 9.19e-37 | -6.79e-01 | -0.1899 |
728190 | NUTM2A-AS1 | A001-C-014 | Human | Colorectum | FAP | 7.45e-20 | -5.67e-01 | 0.0135 |
728190 | NUTM2A-AS1 | A002-C-016 | Human | Colorectum | FAP | 2.69e-23 | -4.84e-01 | 0.0521 |
728190 | NUTM2A-AS1 | A015-C-002 | Human | Colorectum | FAP | 3.74e-21 | -7.09e-01 | -0.0763 |
728190 | NUTM2A-AS1 | A001-C-007 | Human | Colorectum | CRC | 3.95e-06 | -5.60e-01 | 0.1899 |
728190 | NUTM2A-AS1 | A001-C-203 | Human | Colorectum | FAP | 5.97e-15 | -3.98e-01 | -0.0481 |
728190 | NUTM2A-AS1 | A002-C-116 | Human | Colorectum | FAP | 4.00e-35 | -6.18e-01 | -0.0452 |
728190 | NUTM2A-AS1 | A014-C-008 | Human | Colorectum | FAP | 9.76e-21 | -6.73e-01 | -0.191 |
728190 | NUTM2A-AS1 | A018-E-020 | Human | Colorectum | FAP | 3.47e-27 | -6.26e-01 | -0.2034 |
728190 | NUTM2A-AS1 | F034 | Human | Colorectum | FAP | 7.57e-24 | -4.88e-01 | -0.0665 |
728190 | NUTM2A-AS1 | F072B | Human | Colorectum | FAP | 5.59e-14 | -4.35e-01 | 0.257 |
728190 | NUTM2A-AS1 | CRC-1-8810 | Human | Colorectum | CRC | 2.85e-08 | -3.95e-01 | 0.6257 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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