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Gene: NUP50-AS1 |
Gene summary for NUP50-AS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NUP50-AS1 | Gene ID | 100506714 |
Gene name | NUP50 divergent transcript | |
Gene Alias | NUP50-AS1 | |
Cytomap | 22q13.31 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100506714 | NUP50-AS1 | P47T-E | Human | Esophagus | ESCC | 3.42e-03 | 1.33e-01 | 0.1067 |
100506714 | NUP50-AS1 | P49T-E | Human | Esophagus | ESCC | 4.68e-07 | 5.76e-01 | 0.1768 |
100506714 | NUP50-AS1 | P52T-E | Human | Esophagus | ESCC | 3.81e-10 | 1.60e-01 | 0.1555 |
100506714 | NUP50-AS1 | P54T-E | Human | Esophagus | ESCC | 1.90e-03 | 1.01e-01 | 0.0975 |
100506714 | NUP50-AS1 | P62T-E | Human | Esophagus | ESCC | 2.35e-12 | 2.86e-01 | 0.1302 |
100506714 | NUP50-AS1 | P65T-E | Human | Esophagus | ESCC | 3.78e-12 | 1.62e-01 | 0.0978 |
100506714 | NUP50-AS1 | P74T-E | Human | Esophagus | ESCC | 1.32e-24 | 5.85e-01 | 0.1479 |
100506714 | NUP50-AS1 | P80T-E | Human | Esophagus | ESCC | 9.63e-06 | 1.75e-01 | 0.155 |
100506714 | NUP50-AS1 | P82T-E | Human | Esophagus | ESCC | 5.13e-05 | 4.79e-01 | 0.1072 |
100506714 | NUP50-AS1 | P83T-E | Human | Esophagus | ESCC | 3.93e-13 | 5.37e-01 | 0.1738 |
100506714 | NUP50-AS1 | P84T-E | Human | Esophagus | ESCC | 1.27e-05 | 2.45e-01 | 0.0933 |
100506714 | NUP50-AS1 | P89T-E | Human | Esophagus | ESCC | 6.89e-08 | 3.93e-01 | 0.1752 |
100506714 | NUP50-AS1 | P91T-E | Human | Esophagus | ESCC | 3.62e-06 | 4.92e-01 | 0.1828 |
100506714 | NUP50-AS1 | P107T-E | Human | Esophagus | ESCC | 5.51e-09 | 2.84e-01 | 0.171 |
100506714 | NUP50-AS1 | P127T-E | Human | Esophagus | ESCC | 1.28e-06 | 1.03e-01 | 0.0826 |
100506714 | NUP50-AS1 | P128T-E | Human | Esophagus | ESCC | 5.76e-07 | 1.59e-01 | 0.1241 |
100506714 | NUP50-AS1 | P130T-E | Human | Esophagus | ESCC | 2.67e-07 | 2.80e-01 | 0.1676 |
100506714 | NUP50-AS1 | C04 | Human | Oral cavity | OSCC | 5.13e-23 | 9.17e-01 | 0.2633 |
100506714 | NUP50-AS1 | C21 | Human | Oral cavity | OSCC | 4.61e-31 | 8.93e-01 | 0.2678 |
100506714 | NUP50-AS1 | C30 | Human | Oral cavity | OSCC | 4.15e-27 | 1.05e+00 | 0.3055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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