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Gene: NRN1 |
Gene summary for NRN1 |
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Gene information | Species | Human | Gene symbol | NRN1 | Gene ID | 51299 |
Gene name | neuritin 1 | |
Gene Alias | NRN | |
Cytomap | 6p25.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9NPD7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51299 | NRN1 | P62T-E | Human | Esophagus | ESCC | 2.15e-90 | 1.61e+00 | 0.1302 |
51299 | NRN1 | P65T-E | Human | Esophagus | ESCC | 2.45e-17 | 3.98e-01 | 0.0978 |
51299 | NRN1 | P75T-E | Human | Esophagus | ESCC | 2.46e-39 | 8.47e-01 | 0.1125 |
51299 | NRN1 | P76T-E | Human | Esophagus | ESCC | 1.72e-24 | 5.66e-01 | 0.1207 |
51299 | NRN1 | P79T-E | Human | Esophagus | ESCC | 4.90e-27 | 7.22e-01 | 0.1154 |
51299 | NRN1 | P80T-E | Human | Esophagus | ESCC | 3.36e-55 | 2.00e+00 | 0.155 |
51299 | NRN1 | P82T-E | Human | Esophagus | ESCC | 2.11e-02 | 2.09e-01 | 0.1072 |
51299 | NRN1 | P89T-E | Human | Esophagus | ESCC | 3.15e-26 | 1.46e+00 | 0.1752 |
51299 | NRN1 | P130T-E | Human | Esophagus | ESCC | 2.60e-08 | 3.19e-01 | 0.1676 |
51299 | NRN1 | C30 | Human | Oral cavity | OSCC | 1.08e-11 | 6.77e-01 | 0.3055 |
51299 | NRN1 | C43 | Human | Oral cavity | OSCC | 2.54e-30 | 5.80e-01 | 0.1704 |
51299 | NRN1 | C46 | Human | Oral cavity | OSCC | 1.89e-14 | 3.77e-01 | 0.1673 |
51299 | NRN1 | C08 | Human | Oral cavity | OSCC | 1.77e-11 | 4.21e-01 | 0.1919 |
51299 | NRN1 | LN46 | Human | Oral cavity | OSCC | 5.35e-04 | 2.71e-01 | 0.1666 |
51299 | NRN1 | ATC13 | Human | Thyroid | ATC | 1.25e-05 | 1.75e-01 | 0.34 |
51299 | NRN1 | ATC2 | Human | Thyroid | ATC | 2.35e-15 | 1.17e+00 | 0.34 |
51299 | NRN1 | ATC5 | Human | Thyroid | ATC | 2.43e-03 | 1.77e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:006056010 | Esophagus | ESCC | developmental growth involved in morphogenesis | 131/8552 | 234/18723 | 9.28e-04 | 4.73e-03 | 131 |
GO:004858810 | Esophagus | ESCC | developmental cell growth | 125/8552 | 234/18723 | 1.01e-02 | 3.46e-02 | 125 |
GO:001604917 | Oral cavity | OSCC | cell growth | 268/7305 | 482/18723 | 6.55e-14 | 3.51e-12 | 268 |
GO:00485889 | Oral cavity | OSCC | developmental cell growth | 116/7305 | 234/18723 | 6.20e-04 | 3.50e-03 | 116 |
GO:00605609 | Oral cavity | OSCC | developmental growth involved in morphogenesis | 116/7305 | 234/18723 | 6.20e-04 | 3.50e-03 | 116 |
GO:19901388 | Oral cavity | OSCC | neuron projection extension | 86/7305 | 172/18723 | 2.13e-03 | 9.80e-03 | 86 |
GO:001604927 | Thyroid | ATC | cell growth | 241/6293 | 482/18723 | 4.27e-14 | 2.35e-12 | 241 |
GO:199013824 | Thyroid | ATC | neuron projection extension | 89/6293 | 172/18723 | 6.63e-07 | 9.13e-06 | 89 |
GO:004858823 | Thyroid | ATC | developmental cell growth | 114/6293 | 234/18723 | 1.11e-06 | 1.44e-05 | 114 |
GO:006056019 | Thyroid | ATC | developmental growth involved in morphogenesis | 114/6293 | 234/18723 | 1.11e-06 | 1.44e-05 | 114 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NRN1 | SNV | Missense_Mutation | novel | c.176C>T | p.Ala59Val | p.A59V | protein_coding | tolerated(0.18) | possibly_damaging(0.794) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NRN1 | SNV | Missense_Mutation | c.257N>T | p.Thr86Met | p.T86M | protein_coding | tolerated(0.11) | possibly_damaging(0.799) | TCGA-EA-A50E-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | ||
NRN1 | SNV | Missense_Mutation | novel | c.449C>T | p.Ala150Val | p.A150V | protein_coding | tolerated(0.32) | benign(0.288) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
NRN1 | SNV | Missense_Mutation | c.403N>A | p.Glu135Lys | p.E135K | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
NRN1 | SNV | Missense_Mutation | novel | c.194N>T | p.Ser65Leu | p.S65L | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
NRN1 | SNV | Missense_Mutation | c.338N>T | p.Ala113Val | p.A113V | protein_coding | tolerated(0.11) | possibly_damaging(0.72) | TCGA-CM-6675-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | fluorouracil | PD | ||
NRN1 | SNV | Missense_Mutation | c.403G>A | p.Glu135Lys | p.E135K | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
NRN1 | deletion | Frame_Shift_Del | c.337delN | p.Ala113ArgfsTer8 | p.A113Rfs*8 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||||
NRN1 | SNV | Missense_Mutation | novel | c.416G>A | p.Ser139Asn | p.S139N | protein_coding | tolerated(0.11) | benign(0.157) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NRN1 | SNV | Missense_Mutation | c.403N>A | p.Glu135Lys | p.E135K | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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