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Gene: NPIPB12 |
Gene summary for NPIPB12 |
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Gene information | Species | Human | Gene symbol | NPIPB12 | Gene ID | 440353 |
Gene name | nuclear pore complex interacting protein family member B12 | |
Gene Alias | NPIPB12 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
440353 | NPIPB12 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.45e-04 | 3.45e-01 | 0.0446 |
440353 | NPIPB12 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.12e-02 | 1.88e-01 | 0.0528 |
440353 | NPIPB12 | HTA11_7663_2000001011 | Human | Colorectum | SER | 8.62e-08 | 4.36e-01 | 0.0131 |
440353 | NPIPB12 | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.48e-10 | 4.52e-01 | -0.0177 |
440353 | NPIPB12 | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.31e-28 | 6.14e-01 | 0.0338 |
440353 | NPIPB12 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.70e-09 | 2.68e-01 | 0.0674 |
440353 | NPIPB12 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.40e-17 | 7.11e-01 | 0.0112 |
440353 | NPIPB12 | HTA11_11156_2000001011 | Human | Colorectum | AD | 9.72e-05 | 5.17e-01 | 0.0397 |
440353 | NPIPB12 | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.29e-07 | 3.16e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NPIPB12 | SNV | Missense_Mutation | novel | c.792N>T | p.Lys264Asn | p.K264N | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.99) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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