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Gene: NPIPA7 |
Gene summary for NPIPA7 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NPIPA7 | Gene ID | 101059938 |
| Gene name | nuclear pore complex interacting protein family member A7 | |
| Gene Alias | NPIPA8 | |
| Cytomap | 16p13.11 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | E9PJI5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 101059938 | NPIPA7 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.27e-19 | 3.78e-01 | 0.0338 |
| 101059938 | NPIPA7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.55e-12 | 3.19e-01 | 0.0674 |
| 101059938 | NPIPA7 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.42e-04 | 2.64e-01 | 0.0112 |
| 101059938 | NPIPA7 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.02e-03 | 1.48e-01 | 0.0588 |
| 101059938 | NPIPA7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.19e-35 | 8.71e-01 | 0.294 |
| 101059938 | NPIPA7 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.59e-06 | 7.13e-01 | 0.3487 |
| 101059938 | NPIPA7 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.92e-18 | 4.92e-01 | 0.281 |
| 101059938 | NPIPA7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.90e-33 | 8.01e-01 | 0.3859 |
| 101059938 | NPIPA7 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.94e-03 | 2.45e-01 | 0.2585 |
| 101059938 | NPIPA7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.94e-11 | 3.20e-01 | 0.3005 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| NPIPA7 | SNV | Missense_Mutation | novel | c.262G>A | p.Ala88Thr | p.A88T | E9PJI5 | protein_coding | tolerated_low_confidence(0.06) | probably_damaging(1) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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