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Gene: NPDC1 |
Gene summary for NPDC1 |
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Gene information | Species | Human | Gene symbol | NPDC1 | Gene ID | 56654 |
Gene name | neural proliferation, differentiation and control 1 | |
Gene Alias | CAB | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NQX5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56654 | NPDC1 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.38e-03 | 3.75e-01 | 0.0397 |
56654 | NPDC1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.80e-15 | 3.72e-01 | 0.0588 |
56654 | NPDC1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.61e-09 | 2.81e-01 | 0.294 |
56654 | NPDC1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.18e-02 | 3.63e-01 | 0.3487 |
56654 | NPDC1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.64e-04 | 2.41e-01 | 0.281 |
56654 | NPDC1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.92e-06 | 2.56e-01 | 0.3859 |
56654 | NPDC1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.18e-02 | 2.12e-01 | 0.2585 |
56654 | NPDC1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.94e-05 | 2.10e-01 | 0.3005 |
56654 | NPDC1 | AEH-subject1 | Human | Endometrium | AEH | 1.56e-02 | -3.29e-02 | -0.3059 |
56654 | NPDC1 | AEH-subject2 | Human | Endometrium | AEH | 2.84e-04 | 7.04e-02 | -0.2525 |
56654 | NPDC1 | AEH-subject3 | Human | Endometrium | AEH | 8.19e-09 | 1.63e-01 | -0.2576 |
56654 | NPDC1 | AEH-subject4 | Human | Endometrium | AEH | 1.93e-06 | -3.63e-01 | -0.2657 |
56654 | NPDC1 | AEH-subject5 | Human | Endometrium | AEH | 2.00e-19 | -4.07e-01 | -0.2953 |
56654 | NPDC1 | EEC-subject1 | Human | Endometrium | EEC | 1.30e-06 | -1.04e-01 | -0.2682 |
56654 | NPDC1 | EEC-subject2 | Human | Endometrium | EEC | 5.19e-08 | 1.13e-01 | -0.2607 |
56654 | NPDC1 | EEC-subject3 | Human | Endometrium | EEC | 1.08e-37 | -4.17e-01 | -0.2525 |
56654 | NPDC1 | EEC-subject5 | Human | Endometrium | EEC | 1.27e-04 | -1.26e-01 | -0.249 |
56654 | NPDC1 | GSM5276934 | Human | Endometrium | EEC | 6.12e-10 | -3.17e-01 | -0.0913 |
56654 | NPDC1 | GSM5276937 | Human | Endometrium | EEC | 2.91e-02 | -2.36e-01 | -0.0897 |
56654 | NPDC1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 8.70e-21 | -2.28e-01 | -0.1869 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NPDC1 | SNV | Missense_Mutation | c.334N>A | p.Gly112Arg | p.G112R | Q9NQX5 | protein_coding | tolerated(0.48) | benign(0.213) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
NPDC1 | SNV | Missense_Mutation | c.265N>A | p.Gly89Ser | p.G89S | Q9NQX5 | protein_coding | tolerated(0.82) | benign(0.054) | TCGA-BH-A0AV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
NPDC1 | SNV | Missense_Mutation | c.832G>C | p.Glu278Gln | p.E278Q | Q9NQX5 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-E2-A159-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
NPDC1 | insertion | Frame_Shift_Ins | novel | c.350_351insAAGA | p.Leu118ArgfsTer96 | p.L118Rfs*96 | Q9NQX5 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
NPDC1 | SNV | Missense_Mutation | rs778983633 | c.407G>A | p.Arg136Gln | p.R136Q | Q9NQX5 | protein_coding | tolerated(0.23) | benign(0.006) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NPDC1 | SNV | Missense_Mutation | rs564238459 | c.406C>T | p.Arg136Trp | p.R136W | Q9NQX5 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
NPDC1 | SNV | Missense_Mutation | novel | c.141N>A | p.Asp47Glu | p.D47E | Q9NQX5 | protein_coding | tolerated(0.1) | benign(0.207) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NPDC1 | SNV | Missense_Mutation | rs751469138 | c.445N>A | p.Gly149Arg | p.G149R | Q9NQX5 | protein_coding | deleterious(0.05) | probably_damaging(0.929) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
NPDC1 | SNV | Missense_Mutation | rs780477037 | c.928G>A | p.Ala310Thr | p.A310T | Q9NQX5 | protein_coding | tolerated(0.54) | benign(0.001) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NPDC1 | SNV | Missense_Mutation | novel | c.742N>G | p.Met248Val | p.M248V | Q9NQX5 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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