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Gene: NOSIP |
Gene summary for NOSIP |
Gene summary. |
Gene information | Species | Human | Gene symbol | NOSIP | Gene ID | 51070 |
Gene name | nitric oxide synthase interacting protein | |
Gene Alias | CGI-25 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9Y314 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51070 | NOSIP | LZE5T | Human | Esophagus | ESCC | 3.46e-05 | 3.18e-01 | 0.0514 |
51070 | NOSIP | LZE7T | Human | Esophagus | ESCC | 3.00e-10 | 7.88e-01 | 0.0667 |
51070 | NOSIP | LZE8T | Human | Esophagus | ESCC | 1.17e-12 | 5.66e-01 | 0.067 |
51070 | NOSIP | LZE20T | Human | Esophagus | ESCC | 3.50e-10 | 3.16e-01 | 0.0662 |
51070 | NOSIP | LZE22D1 | Human | Esophagus | HGIN | 1.60e-05 | 3.86e-01 | 0.0595 |
51070 | NOSIP | LZE22T | Human | Esophagus | ESCC | 2.82e-06 | 7.45e-01 | 0.068 |
51070 | NOSIP | LZE24T | Human | Esophagus | ESCC | 2.09e-30 | 1.06e+00 | 0.0596 |
51070 | NOSIP | LZE21T | Human | Esophagus | ESCC | 4.71e-04 | 4.92e-01 | 0.0655 |
51070 | NOSIP | LZE6T | Human | Esophagus | ESCC | 3.46e-07 | 5.14e-01 | 0.0845 |
51070 | NOSIP | P1T-E | Human | Esophagus | ESCC | 2.47e-15 | 8.52e-01 | 0.0875 |
51070 | NOSIP | P2T-E | Human | Esophagus | ESCC | 7.72e-33 | 6.83e-01 | 0.1177 |
51070 | NOSIP | P4T-E | Human | Esophagus | ESCC | 5.08e-34 | 8.60e-01 | 0.1323 |
51070 | NOSIP | P5T-E | Human | Esophagus | ESCC | 1.20e-16 | 4.62e-01 | 0.1327 |
51070 | NOSIP | P8T-E | Human | Esophagus | ESCC | 2.05e-79 | 1.55e+00 | 0.0889 |
51070 | NOSIP | P9T-E | Human | Esophagus | ESCC | 6.73e-16 | 6.00e-01 | 0.1131 |
51070 | NOSIP | P10T-E | Human | Esophagus | ESCC | 7.90e-58 | 1.09e+00 | 0.116 |
51070 | NOSIP | P11T-E | Human | Esophagus | ESCC | 4.39e-31 | 1.25e+00 | 0.1426 |
51070 | NOSIP | P12T-E | Human | Esophagus | ESCC | 1.90e-67 | 1.39e+00 | 0.1122 |
51070 | NOSIP | P15T-E | Human | Esophagus | ESCC | 4.82e-42 | 9.39e-01 | 0.1149 |
51070 | NOSIP | P16T-E | Human | Esophagus | ESCC | 2.32e-25 | 4.04e-01 | 0.1153 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051341 | Colorectum | SER | regulation of oxidoreductase activity | 27/2897 | 107/18723 | 5.86e-03 | 4.29e-02 | 27 |
GO:00509991 | Thyroid | PTC | regulation of nitric-oxide synthase activity | 22/5968 | 44/18723 | 9.27e-03 | 3.82e-02 | 22 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOSIP | SNV | Missense_Mutation | c.299N>C | p.Lys100Thr | p.K100T | Q9Y314 | protein_coding | tolerated(0.31) | benign(0.003) | TCGA-EW-A1OZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |
NOSIP | deletion | In_Frame_Del | novel | c.114_131delTGCCGTGAAGGACTTCGA | p.Ala39_Asp44del | p.A39_D44del | Q9Y314 | protein_coding | TCGA-EW-A3U0-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | ||
NOSIP | SNV | Missense_Mutation | rs769816516 | c.334C>T | p.Arg112Trp | p.R112W | Q9Y314 | protein_coding | deleterious(0) | possibly_damaging(0.837) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NOSIP | SNV | Missense_Mutation | c.394A>C | p.Lys132Gln | p.K132Q | Q9Y314 | protein_coding | tolerated(0.24) | benign(0.154) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOSIP | SNV | Missense_Mutation | novel | c.887N>A | p.Arg296Gln | p.R296Q | Q9Y314 | protein_coding | deleterious(0.02) | probably_damaging(0.963) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOSIP | SNV | Missense_Mutation | rs769816516 | c.334N>T | p.Arg112Trp | p.R112W | Q9Y314 | protein_coding | deleterious(0) | possibly_damaging(0.837) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NOSIP | SNV | Missense_Mutation | rs376400410 | c.545N>T | p.Thr182Met | p.T182M | Q9Y314 | protein_coding | deleterious(0.03) | possibly_damaging(0.577) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NOSIP | SNV | Missense_Mutation | c.68N>T | p.Thr23Ile | p.T23I | Q9Y314 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOSIP | SNV | Missense_Mutation | c.284N>A | p.Arg95Gln | p.R95Q | Q9Y314 | protein_coding | tolerated(0.39) | benign(0.001) | TCGA-EI-6510-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOSIP | SNV | Missense_Mutation | rs767271460 | c.649N>T | p.Arg217Cys | p.R217C | Q9Y314 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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