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Gene: NIPA2 |
Gene summary for NIPA2 |
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Gene information | Species | Human | Gene symbol | NIPA2 | Gene ID | 81614 |
Gene name | NIPA magnesium transporter 2 | |
Gene Alias | SLC57A2 | |
Cytomap | 15q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R372 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81614 | NIPA2 | P23T-E | Human | Esophagus | ESCC | 2.73e-21 | 8.09e-01 | 0.108 |
81614 | NIPA2 | P24T-E | Human | Esophagus | ESCC | 1.05e-14 | 3.16e-01 | 0.1287 |
81614 | NIPA2 | P26T-E | Human | Esophagus | ESCC | 2.17e-28 | 5.41e-01 | 0.1276 |
81614 | NIPA2 | P27T-E | Human | Esophagus | ESCC | 3.91e-25 | 1.89e-01 | 0.1055 |
81614 | NIPA2 | P28T-E | Human | Esophagus | ESCC | 8.68e-34 | 7.54e-01 | 0.1149 |
81614 | NIPA2 | P30T-E | Human | Esophagus | ESCC | 6.82e-17 | 9.48e-01 | 0.137 |
81614 | NIPA2 | P31T-E | Human | Esophagus | ESCC | 1.20e-31 | 6.44e-01 | 0.1251 |
81614 | NIPA2 | P32T-E | Human | Esophagus | ESCC | 2.80e-41 | 9.29e-01 | 0.1666 |
81614 | NIPA2 | P36T-E | Human | Esophagus | ESCC | 1.71e-13 | 3.86e-01 | 0.1187 |
81614 | NIPA2 | P37T-E | Human | Esophagus | ESCC | 1.64e-20 | 5.62e-01 | 0.1371 |
81614 | NIPA2 | P39T-E | Human | Esophagus | ESCC | 3.62e-17 | 4.65e-01 | 0.0894 |
81614 | NIPA2 | P40T-E | Human | Esophagus | ESCC | 3.90e-10 | 2.48e-01 | 0.109 |
81614 | NIPA2 | P42T-E | Human | Esophagus | ESCC | 8.66e-14 | 5.00e-01 | 0.1175 |
81614 | NIPA2 | P44T-E | Human | Esophagus | ESCC | 5.64e-14 | 3.04e-01 | 0.1096 |
81614 | NIPA2 | P47T-E | Human | Esophagus | ESCC | 8.54e-27 | 4.07e-01 | 0.1067 |
81614 | NIPA2 | P48T-E | Human | Esophagus | ESCC | 3.47e-14 | 2.09e-01 | 0.0959 |
81614 | NIPA2 | P49T-E | Human | Esophagus | ESCC | 1.47e-08 | 1.36e+00 | 0.1768 |
81614 | NIPA2 | P52T-E | Human | Esophagus | ESCC | 8.85e-29 | 7.56e-01 | 0.1555 |
81614 | NIPA2 | P54T-E | Human | Esophagus | ESCC | 3.13e-16 | 3.17e-01 | 0.0975 |
81614 | NIPA2 | P56T-E | Human | Esophagus | ESCC | 5.49e-10 | 1.16e+00 | 0.1613 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NIPA2 | SNV | Missense_Mutation | novel | c.257C>T | p.Thr86Ile | p.T86I | Q8N8Q9 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
NIPA2 | SNV | Missense_Mutation | c.259C>G | p.Pro87Ala | p.P87A | Q8N8Q9 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NIPA2 | SNV | Missense_Mutation | c.998N>C | p.Asn333Thr | p.N333T | Q8N8Q9 | protein_coding | tolerated(0.13) | benign(0.024) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NIPA2 | SNV | Missense_Mutation | rs776169350 | c.941N>A | p.Arg314Gln | p.R314Q | Q8N8Q9 | protein_coding | tolerated(0.3) | benign(0.017) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NIPA2 | SNV | Missense_Mutation | c.934T>C | p.Ser312Pro | p.S312P | Q8N8Q9 | protein_coding | tolerated(0.29) | benign(0.019) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NIPA2 | SNV | Missense_Mutation | c.550N>G | p.Ile184Val | p.I184V | Q8N8Q9 | protein_coding | tolerated(0.18) | possibly_damaging(0.498) | TCGA-AG-3726-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NIPA2 | SNV | Missense_Mutation | c.320G>T | p.Arg107Ile | p.R107I | Q8N8Q9 | protein_coding | deleterious(0.02) | possibly_damaging(0.493) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
NIPA2 | SNV | Missense_Mutation | rs776169350 | c.941G>A | p.Arg314Gln | p.R314Q | Q8N8Q9 | protein_coding | tolerated(0.3) | benign(0.017) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
NIPA2 | insertion | Frame_Shift_Ins | novel | c.90_91insA | p.Leu35ProfsTer21 | p.L35Pfs*21 | Q8N8Q9 | protein_coding | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
NIPA2 | insertion | Frame_Shift_Ins | novel | c.90_91insA | p.Leu35ProfsTer21 | p.L35Pfs*21 | Q8N8Q9 | protein_coding | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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