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Gene: NHP2 |
Gene summary for NHP2 |
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Gene information | Species | Human | Gene symbol | NHP2 | Gene ID | 55651 |
Gene name | NHP2 ribonucleoprotein | |
Gene Alias | DKCB2 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0000154 | UniProtAcc | J3QSY4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55651 | NHP2 | GSM4909321 | Human | Breast | IDC | 1.44e-23 | 2.53e-01 | 0.1559 |
55651 | NHP2 | brca1 | Human | Breast | Precancer | 4.99e-14 | 4.66e-01 | -0.0338 |
55651 | NHP2 | brca2 | Human | Breast | Precancer | 8.81e-07 | 3.05e-01 | -0.024 |
55651 | NHP2 | brca3 | Human | Breast | Precancer | 1.63e-03 | 2.68e-01 | -0.0263 |
55651 | NHP2 | NCCBC14 | Human | Breast | DCIS | 5.76e-06 | -2.50e-01 | 0.2021 |
55651 | NHP2 | NCCBC2 | Human | Breast | DCIS | 8.77e-04 | 3.28e-02 | 0.1554 |
55651 | NHP2 | NCCBC5 | Human | Breast | DCIS | 1.45e-14 | -4.22e-03 | 0.2046 |
55651 | NHP2 | P1 | Human | Breast | IDC | 1.81e-19 | -3.06e-01 | 0.1527 |
55651 | NHP2 | DCIS2 | Human | Breast | DCIS | 2.61e-58 | 1.28e-01 | 0.0085 |
55651 | NHP2 | AEH-subject1 | Human | Endometrium | AEH | 2.13e-17 | -4.76e-01 | -0.3059 |
55651 | NHP2 | AEH-subject2 | Human | Endometrium | AEH | 1.12e-17 | -5.03e-01 | -0.2525 |
55651 | NHP2 | AEH-subject3 | Human | Endometrium | AEH | 8.46e-12 | -3.51e-01 | -0.2576 |
55651 | NHP2 | AEH-subject4 | Human | Endometrium | AEH | 1.53e-16 | -5.77e-01 | -0.2657 |
55651 | NHP2 | AEH-subject5 | Human | Endometrium | AEH | 7.44e-19 | -5.25e-01 | -0.2953 |
55651 | NHP2 | EEC-subject1 | Human | Endometrium | EEC | 6.28e-21 | -5.05e-01 | -0.2682 |
55651 | NHP2 | EEC-subject2 | Human | Endometrium | EEC | 7.68e-14 | -4.31e-01 | -0.2607 |
55651 | NHP2 | EEC-subject3 | Human | Endometrium | EEC | 1.28e-54 | -5.67e-01 | -0.2525 |
55651 | NHP2 | EEC-subject4 | Human | Endometrium | EEC | 2.18e-15 | -4.81e-01 | -0.2571 |
55651 | NHP2 | EEC-subject5 | Human | Endometrium | EEC | 6.64e-18 | -4.78e-01 | -0.249 |
55651 | NHP2 | GSM5276934 | Human | Endometrium | EEC | 2.22e-06 | -3.59e-01 | -0.0913 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00422549 | Breast | Precancer | ribosome biogenesis | 52/1080 | 299/18723 | 7.35e-13 | 1.51e-10 | 52 |
GO:00422739 | Breast | Precancer | ribosomal large subunit biogenesis | 22/1080 | 72/18723 | 5.03e-11 | 5.61e-09 | 22 |
GO:00063646 | Breast | Precancer | rRNA processing | 35/1080 | 225/18723 | 7.90e-08 | 4.60e-06 | 35 |
GO:00160726 | Breast | Precancer | rRNA metabolic process | 36/1080 | 236/18723 | 8.59e-08 | 4.84e-06 | 36 |
GO:00108338 | Breast | Precancer | telomere maintenance via telomere lengthening | 15/1080 | 81/18723 | 5.31e-05 | 1.11e-03 | 15 |
GO:00007238 | Breast | Precancer | telomere maintenance | 20/1080 | 131/18723 | 6.10e-05 | 1.25e-03 | 20 |
GO:00344705 | Breast | Precancer | ncRNA processing | 42/1080 | 395/18723 | 9.91e-05 | 1.83e-03 | 42 |
GO:19048743 | Breast | Precancer | positive regulation of telomerase RNA localization to Cajal body | 6/1080 | 15/18723 | 1.16e-04 | 2.08e-03 | 6 |
GO:00070047 | Breast | Precancer | telomere maintenance via telomerase | 13/1080 | 69/18723 | 1.37e-04 | 2.38e-03 | 13 |
GO:00062786 | Breast | Precancer | RNA-dependent DNA biosynthetic process | 13/1080 | 75/18723 | 3.27e-04 | 4.64e-03 | 13 |
GO:19048723 | Breast | Precancer | regulation of telomerase RNA localization to Cajal body | 6/1080 | 18/18723 | 3.70e-04 | 5.04e-03 | 6 |
GO:00906703 | Breast | Precancer | RNA localization to Cajal body | 6/1080 | 19/18723 | 5.14e-04 | 6.65e-03 | 6 |
GO:00906713 | Breast | Precancer | telomerase RNA localization to Cajal body | 6/1080 | 19/18723 | 5.14e-04 | 6.65e-03 | 6 |
GO:00906723 | Breast | Precancer | telomerase RNA localization | 6/1080 | 19/18723 | 5.14e-04 | 6.65e-03 | 6 |
GO:00906853 | Breast | Precancer | RNA localization to nucleus | 6/1080 | 19/18723 | 5.14e-04 | 6.65e-03 | 6 |
GO:00322003 | Breast | Precancer | telomere organization | 20/1080 | 159/18723 | 8.45e-04 | 9.82e-03 | 20 |
GO:00004703 | Breast | Precancer | maturation of LSU-rRNA | 7/1080 | 28/18723 | 8.46e-04 | 9.82e-03 | 7 |
GO:00346604 | Breast | Precancer | ncRNA metabolic process | 45/1080 | 485/18723 | 1.15e-03 | 1.26e-02 | 45 |
GO:00064039 | Breast | Precancer | RNA localization | 23/1080 | 201/18723 | 1.34e-03 | 1.41e-02 | 23 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NHP2 | deletion | Frame_Shift_Del | novel | c.99delN | p.Ile34SerfsTer22 | p.I34Sfs*22 | Q9NX24 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
NHP2 | SNV | Missense_Mutation | c.235A>G | p.Met79Val | p.M79V | Q9NX24 | protein_coding | tolerated(1) | benign(0) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NHP2 | SNV | Missense_Mutation | c.418N>A | p.Asp140Asn | p.D140N | Q9NX24 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-CI-6619-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
NHP2 | SNV | Missense_Mutation | c.242N>C | p.Leu81Ser | p.L81S | Q9NX24 | protein_coding | deleterious(0) | possibly_damaging(0.773) | TCGA-B5-A11G-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NHP2 | SNV | Missense_Mutation | rs752392516 | c.364N>T | p.Arg122Cys | p.R122C | Q9NX24 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NHP2 | SNV | Missense_Mutation | novel | c.404N>G | p.Tyr135Cys | p.Y135C | Q9NX24 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
NHP2 | SNV | Missense_Mutation | novel | c.43G>T | p.Ala15Ser | p.A15S | Q9NX24 | protein_coding | tolerated(0.51) | benign(0.018) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NHP2 | SNV | Missense_Mutation | c.177G>C | p.Gln59His | p.Q59H | Q9NX24 | protein_coding | tolerated(0.41) | possibly_damaging(0.77) | TCGA-55-6979-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
NHP2 | SNV | Missense_Mutation | c.418N>A | p.Asp140Asn | p.D140N | Q9NX24 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-L9-A8F4-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NHP2 | SNV | Missense_Mutation | novel | c.259C>G | p.Pro87Ala | p.P87A | Q9NX24 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-34-2609-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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