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Gene: NFIX |
Gene summary for NFIX |
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Gene information | Species | Human | Gene symbol | NFIX | Gene ID | 4784 |
Gene name | nuclear factor I X | |
Gene Alias | CTF | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B4DHW2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4784 | NFIX | CRC-1-8810 | Human | Colorectum | CRC | 6.93e-03 | 6.09e-02 | 0.6257 |
4784 | NFIX | CRC-3-11773 | Human | Colorectum | CRC | 2.67e-07 | 4.12e-01 | 0.2564 |
4784 | NFIX | LZE4T | Human | Esophagus | ESCC | 8.00e-03 | -1.57e-01 | 0.0811 |
4784 | NFIX | LZE7T | Human | Esophagus | ESCC | 5.78e-03 | -1.09e-01 | 0.0667 |
4784 | NFIX | LZE8T | Human | Esophagus | ESCC | 4.51e-02 | -2.05e-01 | 0.067 |
4784 | NFIX | LZE24T | Human | Esophagus | ESCC | 1.16e-10 | 1.94e-01 | 0.0596 |
4784 | NFIX | LZE21T | Human | Esophagus | ESCC | 4.16e-03 | -6.08e-02 | 0.0655 |
4784 | NFIX | P2T-E | Human | Esophagus | ESCC | 3.85e-38 | 7.17e-01 | 0.1177 |
4784 | NFIX | P4T-E | Human | Esophagus | ESCC | 5.56e-09 | 1.42e-01 | 0.1323 |
4784 | NFIX | P5T-E | Human | Esophagus | ESCC | 8.89e-10 | -1.57e-01 | 0.1327 |
4784 | NFIX | P8T-E | Human | Esophagus | ESCC | 3.99e-09 | 1.19e-01 | 0.0889 |
4784 | NFIX | P9T-E | Human | Esophagus | ESCC | 1.86e-06 | 5.91e-02 | 0.1131 |
4784 | NFIX | P10T-E | Human | Esophagus | ESCC | 8.50e-31 | 7.66e-01 | 0.116 |
4784 | NFIX | P12T-E | Human | Esophagus | ESCC | 4.36e-20 | 2.10e-01 | 0.1122 |
4784 | NFIX | P15T-E | Human | Esophagus | ESCC | 4.62e-10 | 1.43e-01 | 0.1149 |
4784 | NFIX | P16T-E | Human | Esophagus | ESCC | 5.99e-16 | 2.01e-01 | 0.1153 |
4784 | NFIX | P20T-E | Human | Esophagus | ESCC | 1.29e-04 | 4.62e-02 | 0.1124 |
4784 | NFIX | P21T-E | Human | Esophagus | ESCC | 3.70e-24 | 3.15e-01 | 0.1617 |
4784 | NFIX | P22T-E | Human | Esophagus | ESCC | 1.04e-17 | 3.14e-02 | 0.1236 |
4784 | NFIX | P23T-E | Human | Esophagus | ESCC | 2.01e-08 | 1.40e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:00062605 | Skin | AK | DNA replication | 40/1910 | 260/18723 | 5.49e-03 | 3.03e-02 | 40 |
GO:000626012 | Skin | cSCC | DNA replication | 106/4864 | 260/18723 | 1.18e-07 | 2.77e-06 | 106 |
GO:00062606 | Thyroid | PTC | DNA replication | 114/5968 | 260/18723 | 3.09e-05 | 2.95e-04 | 114 |
GO:000626013 | Thyroid | ATC | DNA replication | 124/6293 | 260/18723 | 1.58e-06 | 1.93e-05 | 124 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFIX | insertion | Nonsense_Mutation | novel | c.458_459insAGTGAGGGAGAGAGAGAGAGAATAGGTGTGT | p.Pro154ValfsTer8 | p.P154Vfs*8 | Q14938 | protein_coding | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | ||
NFIX | SNV | Missense_Mutation | c.791G>A | p.Arg264Gln | p.R264Q | Q14938 | protein_coding | tolerated(0.06) | benign(0.232) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NFIX | SNV | Missense_Mutation | c.889N>A | p.Gly297Arg | p.G297R | Q14938 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-EF-5830-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NFIX | SNV | Missense_Mutation | novel | c.310G>A | p.Val104Met | p.V104M | Q14938 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | novel | c.184G>T | p.Gly62Cys | p.G62C | Q14938 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | c.830N>A | p.Arg277His | p.R277H | Q14938 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NFIX | SNV | Missense_Mutation | rs771724729 | c.239G>A | p.Arg80His | p.R80H | Q14938 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | novel | c.959N>T | p.Pro320Leu | p.P320L | Q14938 | protein_coding | tolerated(0.85) | benign(0.009) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | novel | c.671T>C | p.Val224Ala | p.V224A | Q14938 | protein_coding | tolerated(0.08) | probably_damaging(0.991) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NFIX | SNV | Missense_Mutation | novel | c.305N>T | p.Cys102Phe | p.C102F | Q14938 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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