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Gene: NET1 |
Gene summary for NET1 |
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Gene information | Species | Human | Gene symbol | NET1 | Gene ID | 10276 |
Gene name | neuroepithelial cell transforming 1 | |
Gene Alias | ARHGEF8 | |
Cytomap | 10p15.1 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | Q5SQI5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10276 | NET1 | LZE8T | Human | Esophagus | ESCC | 5.75e-03 | 4.08e-01 | 0.067 |
10276 | NET1 | LZE20T | Human | Esophagus | ESCC | 7.24e-07 | -1.74e-02 | 0.0662 |
10276 | NET1 | LZE24T | Human | Esophagus | ESCC | 3.79e-09 | 7.88e-01 | 0.0596 |
10276 | NET1 | P1T-E | Human | Esophagus | ESCC | 5.96e-03 | 7.43e-01 | 0.0875 |
10276 | NET1 | P2T-E | Human | Esophagus | ESCC | 1.13e-11 | 6.74e-01 | 0.1177 |
10276 | NET1 | P4T-E | Human | Esophagus | ESCC | 2.19e-17 | 7.27e-01 | 0.1323 |
10276 | NET1 | P5T-E | Human | Esophagus | ESCC | 3.81e-19 | 7.58e-01 | 0.1327 |
10276 | NET1 | P8T-E | Human | Esophagus | ESCC | 8.30e-11 | 5.21e-01 | 0.0889 |
10276 | NET1 | P9T-E | Human | Esophagus | ESCC | 1.14e-09 | -1.92e-01 | 0.1131 |
10276 | NET1 | P10T-E | Human | Esophagus | ESCC | 3.69e-22 | 7.94e-01 | 0.116 |
10276 | NET1 | P11T-E | Human | Esophagus | ESCC | 1.16e-10 | 1.02e+00 | 0.1426 |
10276 | NET1 | P12T-E | Human | Esophagus | ESCC | 3.03e-24 | 1.38e+00 | 0.1122 |
10276 | NET1 | P15T-E | Human | Esophagus | ESCC | 5.64e-26 | 9.52e-01 | 0.1149 |
10276 | NET1 | P16T-E | Human | Esophagus | ESCC | 1.95e-18 | 7.59e-01 | 0.1153 |
10276 | NET1 | P20T-E | Human | Esophagus | ESCC | 9.71e-20 | 9.42e-01 | 0.1124 |
10276 | NET1 | P21T-E | Human | Esophagus | ESCC | 1.21e-36 | 1.30e+00 | 0.1617 |
10276 | NET1 | P22T-E | Human | Esophagus | ESCC | 4.53e-11 | 3.89e-01 | 0.1236 |
10276 | NET1 | P23T-E | Human | Esophagus | ESCC | 3.93e-11 | 6.57e-01 | 0.108 |
10276 | NET1 | P26T-E | Human | Esophagus | ESCC | 3.21e-16 | 6.47e-01 | 0.1276 |
10276 | NET1 | P27T-E | Human | Esophagus | ESCC | 8.69e-20 | 8.88e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0000302 | Colorectum | AD | response to reactive oxygen species | 78/3918 | 222/18723 | 6.17e-07 | 2.21e-05 | 78 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0034599 | Colorectum | AD | cellular response to oxidative stress | 94/3918 | 288/18723 | 2.03e-06 | 6.02e-05 | 94 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0042542 | Colorectum | AD | response to hydrogen peroxide | 52/3918 | 146/18723 | 2.83e-05 | 5.30e-04 | 52 |
GO:0034614 | Colorectum | AD | cellular response to reactive oxygen species | 50/3918 | 155/18723 | 6.25e-04 | 6.49e-03 | 50 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:0046578 | Colorectum | AD | regulation of Ras protein signal transduction | 56/3918 | 189/18723 | 2.85e-03 | 2.14e-02 | 56 |
GO:0007266 | Colorectum | AD | Rho protein signal transduction | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
GO:00069792 | Colorectum | MSS | response to oxidative stress | 128/3467 | 446/18723 | 7.65e-08 | 3.81e-06 | 128 |
GO:00621972 | Colorectum | MSS | cellular response to chemical stress | 102/3467 | 337/18723 | 9.73e-08 | 4.71e-06 | 102 |
GO:00345992 | Colorectum | MSS | cellular response to oxidative stress | 88/3467 | 288/18723 | 4.58e-07 | 1.77e-05 | 88 |
GO:00430872 | Colorectum | MSS | regulation of GTPase activity | 101/3467 | 348/18723 | 1.00e-06 | 3.46e-05 | 101 |
GO:00003022 | Colorectum | MSS | response to reactive oxygen species | 67/3467 | 222/18723 | 1.60e-05 | 3.60e-04 | 67 |
GO:00160492 | Colorectum | MSS | cell growth | 123/3467 | 482/18723 | 7.15e-05 | 1.21e-03 | 123 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NET1 | SNV | Missense_Mutation | novel | c.500N>T | p.Ser167Phe | p.S167F | Q7Z628 | protein_coding | deleterious(0.03) | benign(0.396) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
NET1 | SNV | Missense_Mutation | c.727N>A | p.Asp243Asn | p.D243N | Q7Z628 | protein_coding | tolerated(0.09) | benign(0.015) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
NET1 | SNV | Missense_Mutation | rs773238555 | c.1081G>A | p.Glu361Lys | p.E361K | Q7Z628 | protein_coding | tolerated(0.19) | benign(0.075) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NET1 | SNV | Missense_Mutation | c.199N>G | p.Arg67Gly | p.R67G | Q7Z628 | protein_coding | deleterious(0) | possibly_damaging(0.528) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
NET1 | SNV | Missense_Mutation | c.296N>T | p.Thr99Met | p.T99M | Q7Z628 | protein_coding | deleterious(0) | possibly_damaging(0.879) | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NET1 | SNV | Missense_Mutation | c.272G>C | p.Arg91Thr | p.R91T | Q7Z628 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-LP-A4AX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NET1 | SNV | Missense_Mutation | c.449G>C | p.Arg150Thr | p.R150T | Q7Z628 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NET1 | SNV | Missense_Mutation | c.868N>A | p.Leu290Ile | p.L290I | Q7Z628 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NET1 | SNV | Missense_Mutation | c.1038N>G | p.Ile346Met | p.I346M | Q7Z628 | protein_coding | deleterious(0.01) | possibly_damaging(0.487) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
NET1 | SNV | Missense_Mutation | c.1019N>G | p.Glu340Gly | p.E340G | Q7Z628 | protein_coding | deleterious(0.04) | benign(0.073) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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