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Gene: NEO1 |
Gene summary for NEO1 |
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Gene information | Species | Human | Gene symbol | NEO1 | Gene ID | 4756 |
Gene name | neogenin 1 | |
Gene Alias | IGDCC2 | |
Cytomap | 15q24.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q59FP8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4756 | NEO1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.75e-56 | -9.58e-01 | 0.3859 |
4756 | NEO1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.05e-28 | -1.19e+00 | 0.2585 |
4756 | NEO1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.47e-59 | -9.96e-01 | 0.3005 |
4756 | NEO1 | F007 | Human | Colorectum | FAP | 4.01e-20 | -9.22e-01 | 0.1176 |
4756 | NEO1 | A002-C-010 | Human | Colorectum | FAP | 9.90e-20 | -5.50e-01 | 0.242 |
4756 | NEO1 | A001-C-207 | Human | Colorectum | FAP | 1.65e-26 | -9.41e-01 | 0.1278 |
4756 | NEO1 | A015-C-203 | Human | Colorectum | FAP | 2.52e-46 | -9.54e-01 | -0.1294 |
4756 | NEO1 | A015-C-204 | Human | Colorectum | FAP | 8.79e-27 | -9.25e-01 | -0.0228 |
4756 | NEO1 | A014-C-040 | Human | Colorectum | FAP | 4.09e-09 | -7.40e-01 | -0.1184 |
4756 | NEO1 | A002-C-201 | Human | Colorectum | FAP | 1.41e-43 | -1.04e+00 | 0.0324 |
4756 | NEO1 | A002-C-203 | Human | Colorectum | FAP | 4.67e-32 | -8.22e-01 | 0.2786 |
4756 | NEO1 | A001-C-119 | Human | Colorectum | FAP | 2.88e-37 | -1.20e+00 | -0.1557 |
4756 | NEO1 | A001-C-108 | Human | Colorectum | FAP | 9.38e-60 | -1.13e+00 | -0.0272 |
4756 | NEO1 | A002-C-021 | Human | Colorectum | FAP | 4.25e-12 | -3.35e-01 | 0.1171 |
4756 | NEO1 | A002-C-205 | Human | Colorectum | FAP | 2.43e-56 | -1.15e+00 | -0.1236 |
4756 | NEO1 | A014-C-108 | Human | Colorectum | FAP | 7.33e-06 | -4.82e-01 | -0.124 |
4756 | NEO1 | A001-C-104 | Human | Colorectum | FAP | 2.56e-38 | -9.21e-01 | 0.0184 |
4756 | NEO1 | A015-C-005 | Human | Colorectum | FAP | 9.26e-11 | -5.62e-01 | -0.0336 |
4756 | NEO1 | A015-C-006 | Human | Colorectum | FAP | 7.23e-44 | -1.20e+00 | -0.0994 |
4756 | NEO1 | A015-C-106 | Human | Colorectum | FAP | 2.39e-27 | -7.27e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0055076 | Colorectum | AD | transition metal ion homeostasis | 53/3918 | 138/18723 | 1.89e-06 | 5.65e-05 | 53 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0055072 | Colorectum | AD | iron ion homeostasis | 32/3918 | 85/18723 | 2.97e-04 | 3.60e-03 | 32 |
GO:0007178 | Colorectum | AD | transmembrane receptor protein serine/threonine kinase signaling pathway | 99/3918 | 355/18723 | 9.92e-04 | 9.28e-03 | 99 |
GO:0007411 | Colorectum | AD | axon guidance | 64/3918 | 227/18723 | 5.41e-03 | 3.55e-02 | 64 |
GO:0097485 | Colorectum | AD | neuron projection guidance | 64/3918 | 228/18723 | 6.02e-03 | 3.78e-02 | 64 |
GO:00550761 | Colorectum | SER | transition metal ion homeostasis | 41/2897 | 138/18723 | 1.66e-05 | 5.05e-04 | 41 |
GO:00550721 | Colorectum | SER | iron ion homeostasis | 24/2897 | 85/18723 | 1.91e-03 | 1.93e-02 | 24 |
GO:00074111 | Colorectum | SER | axon guidance | 51/2897 | 227/18723 | 3.29e-03 | 2.82e-02 | 51 |
GO:00974851 | Colorectum | SER | neuron projection guidance | 51/2897 | 228/18723 | 3.61e-03 | 3.03e-02 | 51 |
GO:00615641 | Colorectum | SER | axon development | 94/2897 | 467/18723 | 3.78e-03 | 3.13e-02 | 94 |
GO:00074091 | Colorectum | SER | axonogenesis | 84/2897 | 418/18723 | 6.20e-03 | 4.49e-02 | 84 |
GO:00550762 | Colorectum | MSS | transition metal ion homeostasis | 45/3467 | 138/18723 | 4.99e-05 | 9.02e-04 | 45 |
GO:00074092 | Colorectum | MSS | axonogenesis | 105/3467 | 418/18723 | 4.32e-04 | 5.23e-03 | 105 |
GO:00550722 | Colorectum | MSS | iron ion homeostasis | 29/3467 | 85/18723 | 4.44e-04 | 5.32e-03 | 29 |
GO:00615642 | Colorectum | MSS | axon development | 115/3467 | 467/18723 | 5.33e-04 | 6.00e-03 | 115 |
GO:00071781 | Colorectum | MSS | transmembrane receptor protein serine/threonine kinase signaling pathway | 86/3467 | 355/18723 | 4.04e-03 | 2.95e-02 | 86 |
GO:00615643 | Colorectum | FAP | axon development | 106/2622 | 467/18723 | 1.98e-07 | 1.21e-05 | 106 |
GO:00074093 | Colorectum | FAP | axonogenesis | 97/2622 | 418/18723 | 2.20e-07 | 1.30e-05 | 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04360 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa043601 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa04350 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa043501 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa043602 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043603 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043604 | Colorectum | FAP | Axon guidance | 47/1404 | 182/8465 | 9.09e-04 | 5.20e-03 | 3.16e-03 | 47 |
hsa043605 | Colorectum | FAP | Axon guidance | 47/1404 | 182/8465 | 9.09e-04 | 5.20e-03 | 3.16e-03 | 47 |
hsa043606 | Colorectum | CRC | Axon guidance | 43/1091 | 182/8465 | 4.38e-05 | 8.70e-04 | 5.90e-04 | 43 |
hsa043607 | Colorectum | CRC | Axon guidance | 43/1091 | 182/8465 | 4.38e-05 | 8.70e-04 | 5.90e-04 | 43 |
hsa043504 | Endometrium | AEH | TGF-beta signaling pathway | 26/1197 | 108/8465 | 3.82e-03 | 2.18e-02 | 1.59e-02 | 26 |
hsa0436010 | Endometrium | AEH | Axon guidance | 39/1197 | 182/8465 | 4.47e-03 | 2.46e-02 | 1.80e-02 | 39 |
hsa0435011 | Endometrium | AEH | TGF-beta signaling pathway | 26/1197 | 108/8465 | 3.82e-03 | 2.18e-02 | 1.59e-02 | 26 |
hsa0436013 | Endometrium | AEH | Axon guidance | 39/1197 | 182/8465 | 4.47e-03 | 2.46e-02 | 1.80e-02 | 39 |
hsa043502 | Endometrium | EEC | TGF-beta signaling pathway | 26/1237 | 108/8465 | 5.95e-03 | 3.12e-02 | 2.33e-02 | 26 |
hsa0436022 | Endometrium | EEC | Axon guidance | 39/1237 | 182/8465 | 7.78e-03 | 3.66e-02 | 2.73e-02 | 39 |
hsa043503 | Endometrium | EEC | TGF-beta signaling pathway | 26/1237 | 108/8465 | 5.95e-03 | 3.12e-02 | 2.33e-02 | 26 |
hsa0436032 | Endometrium | EEC | Axon guidance | 39/1237 | 182/8465 | 7.78e-03 | 3.66e-02 | 2.73e-02 | 39 |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0436016 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NEO1 | SNV | Missense_Mutation | c.2509N>A | p.Asp837Asn | p.D837N | Q92859 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NEO1 | SNV | Missense_Mutation | c.979N>A | p.Glu327Lys | p.E327K | Q92859 | protein_coding | tolerated(0.2) | benign(0.007) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
NEO1 | SNV | Missense_Mutation | c.1000N>C | p.Glu334Gln | p.E334Q | Q92859 | protein_coding | tolerated(0.3) | benign(0.079) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
NEO1 | SNV | Missense_Mutation | c.412A>C | p.Thr138Pro | p.T138P | Q92859 | protein_coding | deleterious(0.04) | possibly_damaging(0.826) | TCGA-E2-A14W-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD | |
NEO1 | deletion | Frame_Shift_Del | novel | c.4196delN | p.Thr1399LysfsTer7 | p.T1399Kfs*7 | Q92859 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
NEO1 | SNV | Missense_Mutation | novel | c.3699G>A | p.Met1233Ile | p.M1233I | Q92859 | protein_coding | tolerated(0.11) | benign(0.316) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
NEO1 | SNV | Missense_Mutation | c.2834C>T | p.Ala945Val | p.A945V | Q92859 | protein_coding | tolerated(0.2) | possibly_damaging(0.528) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
NEO1 | SNV | Missense_Mutation | rs142333707 | c.1373N>T | p.Thr458Met | p.T458M | Q92859 | protein_coding | deleterious(0.03) | possibly_damaging(0.872) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NEO1 | SNV | Missense_Mutation | c.400N>A | p.Glu134Lys | p.E134K | Q92859 | protein_coding | tolerated(0.1) | benign(0.201) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
NEO1 | SNV | Missense_Mutation | c.191N>T | p.Ser64Leu | p.S64L | Q92859 | protein_coding | deleterious(0.04) | benign(0.102) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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