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Gene: NBPF14 |
Gene summary for NBPF14 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NBPF14 | Gene ID | 25832 |
Gene name | NBPF member 14 | |
Gene Alias | DJ328E19.C1.1 | |
Cytomap | 1q21.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A087WZJ2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25832 | NBPF14 | P11T-E | Human | Esophagus | ESCC | 1.80e-18 | 6.05e-01 | 0.1426 |
25832 | NBPF14 | P12T-E | Human | Esophagus | ESCC | 6.72e-08 | 3.90e-02 | 0.1122 |
25832 | NBPF14 | P15T-E | Human | Esophagus | ESCC | 1.69e-06 | 6.49e-02 | 0.1149 |
25832 | NBPF14 | P16T-E | Human | Esophagus | ESCC | 7.47e-21 | 3.69e-01 | 0.1153 |
25832 | NBPF14 | P20T-E | Human | Esophagus | ESCC | 6.08e-03 | 3.69e-02 | 0.1124 |
25832 | NBPF14 | P21T-E | Human | Esophagus | ESCC | 6.99e-04 | 5.81e-02 | 0.1617 |
25832 | NBPF14 | P22T-E | Human | Esophagus | ESCC | 1.00e-13 | 6.99e-02 | 0.1236 |
25832 | NBPF14 | P23T-E | Human | Esophagus | ESCC | 5.90e-06 | 1.84e-01 | 0.108 |
25832 | NBPF14 | P24T-E | Human | Esophagus | ESCC | 4.41e-06 | 6.48e-02 | 0.1287 |
25832 | NBPF14 | P26T-E | Human | Esophagus | ESCC | 1.46e-09 | 8.61e-02 | 0.1276 |
25832 | NBPF14 | P27T-E | Human | Esophagus | ESCC | 3.56e-04 | 1.56e-02 | 0.1055 |
25832 | NBPF14 | P28T-E | Human | Esophagus | ESCC | 3.03e-17 | 3.20e-01 | 0.1149 |
25832 | NBPF14 | P31T-E | Human | Esophagus | ESCC | 1.11e-04 | 1.15e-01 | 0.1251 |
25832 | NBPF14 | P32T-E | Human | Esophagus | ESCC | 6.00e-07 | 1.11e-01 | 0.1666 |
25832 | NBPF14 | P36T-E | Human | Esophagus | ESCC | 5.06e-06 | 2.80e-01 | 0.1187 |
25832 | NBPF14 | P37T-E | Human | Esophagus | ESCC | 4.88e-06 | 1.46e-01 | 0.1371 |
25832 | NBPF14 | P40T-E | Human | Esophagus | ESCC | 1.63e-02 | 1.14e-01 | 0.109 |
25832 | NBPF14 | P42T-E | Human | Esophagus | ESCC | 5.68e-03 | 5.97e-02 | 0.1175 |
25832 | NBPF14 | P47T-E | Human | Esophagus | ESCC | 2.49e-05 | 4.00e-02 | 0.1067 |
25832 | NBPF14 | P48T-E | Human | Esophagus | ESCC | 3.62e-26 | 4.81e-01 | 0.0959 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NBPF14 | SNV | Missense_Mutation | novel | c.4984G>A | p.Asp1662Asn | p.D1662N | protein_coding | deleterious(0.02) | possibly_damaging(0.728) | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.3493N>T | p.Ile1165Phe | p.I1165F | protein_coding | tolerated(0.07) | benign(0.249) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.5N>C | p.Val2Ala | p.V2A | protein_coding | tolerated(0.06) | benign(0.285) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.8605G>A | p.Asp2869Asn | p.D2869N | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
NBPF14 | SNV | Missense_Mutation | novel | c.1081N>A | p.Glu361Lys | p.E361K | protein_coding | deleterious(0.02) | possibly_damaging(0.486) | TCGA-C8-A12X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.1827N>T | p.Lys609Asn | p.K609N | protein_coding | deleterious(0.03) | probably_damaging(0.938) | TCGA-EW-A1OX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.193G>C | p.Asp65His | p.D65H | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
NBPF14 | insertion | Frame_Shift_Ins | novel | c.8645_8646insT | p.Arg2882SerfsTer39 | p.R2882Sfs*39 | protein_coding | TCGA-AR-A5QQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |||
NBPF14 | SNV | Missense_Mutation | novel | c.251N>G | p.Glu84Gly | p.E84G | protein_coding | deleterious(0) | possibly_damaging(0.479) | TCGA-EA-A97N-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
NBPF14 | SNV | Missense_Mutation | novel | c.1044N>G | p.Phe348Leu | p.F348L | protein_coding | tolerated(0.22) | benign(0.294) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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