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Gene: MUM1 |
Gene summary for MUM1 |
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Gene information | Species | Human | Gene symbol | MUM1 | Gene ID | 84939 |
Gene name | PWWP domain containing 3A, DNA repair factor | |
Gene Alias | EXPAND1 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | J3KNX4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84939 | MUM1 | P30T-E | Human | Esophagus | ESCC | 4.37e-19 | 5.02e-01 | 0.137 |
84939 | MUM1 | P31T-E | Human | Esophagus | ESCC | 1.08e-22 | 3.90e-01 | 0.1251 |
84939 | MUM1 | P32T-E | Human | Esophagus | ESCC | 7.00e-23 | 4.18e-01 | 0.1666 |
84939 | MUM1 | P36T-E | Human | Esophagus | ESCC | 1.91e-13 | 3.77e-01 | 0.1187 |
84939 | MUM1 | P37T-E | Human | Esophagus | ESCC | 3.18e-21 | 4.16e-01 | 0.1371 |
84939 | MUM1 | P39T-E | Human | Esophagus | ESCC | 2.12e-17 | 2.65e-01 | 0.0894 |
84939 | MUM1 | P40T-E | Human | Esophagus | ESCC | 1.17e-09 | 1.76e-01 | 0.109 |
84939 | MUM1 | P42T-E | Human | Esophagus | ESCC | 2.06e-26 | 5.73e-01 | 0.1175 |
84939 | MUM1 | P44T-E | Human | Esophagus | ESCC | 2.28e-09 | 2.97e-01 | 0.1096 |
84939 | MUM1 | P47T-E | Human | Esophagus | ESCC | 1.64e-15 | 3.09e-01 | 0.1067 |
84939 | MUM1 | P48T-E | Human | Esophagus | ESCC | 2.32e-19 | 3.38e-01 | 0.0959 |
84939 | MUM1 | P49T-E | Human | Esophagus | ESCC | 5.15e-05 | 6.99e-01 | 0.1768 |
84939 | MUM1 | P52T-E | Human | Esophagus | ESCC | 9.46e-25 | 5.07e-01 | 0.1555 |
84939 | MUM1 | P54T-E | Human | Esophagus | ESCC | 5.78e-27 | 6.57e-01 | 0.0975 |
84939 | MUM1 | P56T-E | Human | Esophagus | ESCC | 3.67e-13 | 7.23e-01 | 0.1613 |
84939 | MUM1 | P57T-E | Human | Esophagus | ESCC | 1.92e-15 | 3.43e-01 | 0.0926 |
84939 | MUM1 | P61T-E | Human | Esophagus | ESCC | 1.99e-32 | 6.80e-01 | 0.099 |
84939 | MUM1 | P62T-E | Human | Esophagus | ESCC | 1.97e-34 | 5.26e-01 | 0.1302 |
84939 | MUM1 | P65T-E | Human | Esophagus | ESCC | 1.80e-19 | 3.23e-01 | 0.0978 |
84939 | MUM1 | P74T-E | Human | Esophagus | ESCC | 5.48e-24 | 5.61e-01 | 0.1479 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUM1 | SNV | Missense_Mutation | novel | c.862N>A | p.Glu288Lys | p.E288K | protein_coding | tolerated(0.3) | benign(0.108) | TCGA-AC-A8OS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MUM1 | SNV | Missense_Mutation | novel | c.278N>A | p.Arg93His | p.R93H | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MUM1 | SNV | Missense_Mutation | c.137T>C | p.Leu46Pro | p.L46P | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MUM1 | SNV | Missense_Mutation | rs147961437 | c.232G>A | p.Val78Ile | p.V78I | protein_coding | tolerated(0.17) | benign(0.105) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MUM1 | SNV | Missense_Mutation | c.1115N>G | p.Glu372Gly | p.E372G | protein_coding | tolerated(0.19) | benign(0) | TCGA-E9-A24A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
MUM1 | SNV | Missense_Mutation | c.1378N>T | p.Leu460Phe | p.L460F | protein_coding | tolerated(0.41) | probably_damaging(0.976) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
MUM1 | insertion | In_Frame_Ins | novel | c.432_433insCAGAATTTGCCCCTAGAACCACTCCTATTC | p.Val144_Leu145insGlnAsnLeuProLeuGluProLeuLeuPhe | p.V144_L145insQNLPLEPLLF | protein_coding | TCGA-A8-A06U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
MUM1 | deletion | Frame_Shift_Del | novel | c.1102delN | p.Lys368SerfsTer45 | p.K368Sfs*45 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
MUM1 | SNV | Missense_Mutation | rs773907661 | c.308N>T | p.Ser103Leu | p.S103L | protein_coding | tolerated(0.07) | benign(0.001) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MUM1 | SNV | Missense_Mutation | c.707N>T | p.Ser236Leu | p.S236L | protein_coding | tolerated(0.16) | benign(0.14) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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