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Gene: MTX2 |
Gene summary for MTX2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MTX2 | Gene ID | 10651 |
Gene name | metaxin 2 | |
Gene Alias | MDPS | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | O75431 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10651 | MTX2 | F007 | Human | Colorectum | FAP | 9.05e-04 | -4.38e-01 | 0.1176 |
10651 | MTX2 | A001-C-207 | Human | Colorectum | FAP | 2.99e-04 | -3.81e-01 | 0.1278 |
10651 | MTX2 | A015-C-203 | Human | Colorectum | FAP | 1.25e-32 | -6.06e-01 | -0.1294 |
10651 | MTX2 | A015-C-204 | Human | Colorectum | FAP | 1.32e-06 | -4.43e-01 | -0.0228 |
10651 | MTX2 | A014-C-040 | Human | Colorectum | FAP | 1.93e-04 | -5.06e-01 | -0.1184 |
10651 | MTX2 | A002-C-201 | Human | Colorectum | FAP | 1.10e-15 | -4.71e-01 | 0.0324 |
10651 | MTX2 | A002-C-203 | Human | Colorectum | FAP | 1.99e-05 | -3.25e-01 | 0.2786 |
10651 | MTX2 | A001-C-119 | Human | Colorectum | FAP | 1.72e-19 | -7.79e-01 | -0.1557 |
10651 | MTX2 | A001-C-108 | Human | Colorectum | FAP | 3.57e-28 | -6.24e-01 | -0.0272 |
10651 | MTX2 | A002-C-205 | Human | Colorectum | FAP | 5.79e-28 | -6.76e-01 | -0.1236 |
10651 | MTX2 | A014-C-108 | Human | Colorectum | FAP | 2.15e-03 | -4.66e-01 | -0.124 |
10651 | MTX2 | A001-C-104 | Human | Colorectum | FAP | 6.77e-11 | -4.69e-01 | 0.0184 |
10651 | MTX2 | A015-C-005 | Human | Colorectum | FAP | 8.97e-08 | -4.82e-01 | -0.0336 |
10651 | MTX2 | A015-C-006 | Human | Colorectum | FAP | 7.30e-21 | -6.90e-01 | -0.0994 |
10651 | MTX2 | A015-C-106 | Human | Colorectum | FAP | 1.22e-13 | -3.92e-01 | -0.0511 |
10651 | MTX2 | A002-C-114 | Human | Colorectum | FAP | 3.84e-21 | -6.14e-01 | -0.1561 |
10651 | MTX2 | A015-C-104 | Human | Colorectum | FAP | 7.01e-33 | -5.93e-01 | -0.1899 |
10651 | MTX2 | A001-C-014 | Human | Colorectum | FAP | 1.67e-19 | -5.25e-01 | 0.0135 |
10651 | MTX2 | A002-C-016 | Human | Colorectum | FAP | 5.87e-24 | -5.66e-01 | 0.0521 |
10651 | MTX2 | A015-C-002 | Human | Colorectum | FAP | 1.23e-16 | -6.64e-01 | -0.0763 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068399 | Cervix | CC | mitochondrial transport | 60/2311 | 254/18723 | 4.21e-07 | 1.67e-05 | 60 |
GO:00070067 | Cervix | CC | mitochondrial membrane organization | 28/2311 | 116/18723 | 3.28e-04 | 3.47e-03 | 28 |
GO:00070074 | Cervix | CC | inner mitochondrial membrane organization | 11/2311 | 38/18723 | 4.94e-03 | 2.95e-02 | 11 |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0007006 | Colorectum | AD | mitochondrial membrane organization | 48/3918 | 116/18723 | 4.53e-07 | 1.72e-05 | 48 |
GO:0007007 | Colorectum | AD | inner mitochondrial membrane organization | 18/3918 | 38/18723 | 2.45e-04 | 3.09e-03 | 18 |
GO:00068392 | Colorectum | MSS | mitochondrial transport | 93/3467 | 254/18723 | 6.14e-12 | 9.82e-10 | 93 |
GO:00070062 | Colorectum | MSS | mitochondrial membrane organization | 42/3467 | 116/18723 | 4.99e-06 | 1.38e-04 | 42 |
GO:00070072 | Colorectum | MSS | inner mitochondrial membrane organization | 14/3467 | 38/18723 | 6.00e-03 | 4.03e-02 | 14 |
GO:00068394 | Colorectum | FAP | mitochondrial transport | 55/2622 | 254/18723 | 5.58e-04 | 6.24e-03 | 55 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:000700619 | Esophagus | ESCC | mitochondrial membrane organization | 93/8552 | 116/18723 | 2.16e-14 | 1.11e-12 | 93 |
GO:000700713 | Esophagus | ESCC | inner mitochondrial membrane organization | 31/8552 | 38/18723 | 5.93e-06 | 6.10e-05 | 31 |
GO:00068397 | Liver | Cirrhotic | mitochondrial transport | 112/4634 | 254/18723 | 1.03e-11 | 6.66e-10 | 112 |
GO:00070065 | Liver | Cirrhotic | mitochondrial membrane organization | 57/4634 | 116/18723 | 1.13e-08 | 4.29e-07 | 57 |
GO:00070073 | Liver | Cirrhotic | inner mitochondrial membrane organization | 19/4634 | 38/18723 | 6.75e-04 | 5.06e-03 | 19 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
GO:000700612 | Liver | HCC | mitochondrial membrane organization | 80/7958 | 116/18723 | 7.09e-09 | 1.81e-07 | 80 |
GO:000700711 | Liver | HCC | inner mitochondrial membrane organization | 28/7958 | 38/18723 | 9.60e-05 | 8.34e-04 | 28 |
GO:000683918 | Oral cavity | OSCC | mitochondrial transport | 162/7305 | 254/18723 | 8.96e-16 | 6.52e-14 | 162 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTX2 | SNV | Missense_Mutation | c.567N>G | p.Cys189Trp | p.C189W | O75431 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-B6-A0WX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
MTX2 | insertion | Frame_Shift_Ins | novel | c.343_344insCACATGCTGCTAATTTTTTTGTTTGTTTTGTTTTGTTTTT | p.Met115ThrfsTer32 | p.M115Tfs*32 | O75431 | protein_coding | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | ||
MTX2 | SNV | Missense_Mutation | novel | c.190G>A | p.Glu64Lys | p.E64K | O75431 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-EA-A97N-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MTX2 | SNV | Missense_Mutation | c.25N>A | p.Val9Ile | p.V9I | O75431 | protein_coding | tolerated(0.46) | benign(0.015) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTX2 | SNV | Missense_Mutation | c.575C>T | p.Ala192Val | p.A192V | O75431 | protein_coding | deleterious(0.01) | possibly_damaging(0.868) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
MTX2 | SNV | Missense_Mutation | rs867441047 | c.758A>G | p.Tyr253Cys | p.Y253C | O75431 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-QG-A5Z1-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
MTX2 | SNV | Missense_Mutation | novel | c.92N>T | p.Glu31Val | p.E31V | O75431 | protein_coding | deleterious(0.05) | benign(0.142) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MTX2 | SNV | Missense_Mutation | c.467N>G | p.Ile156Ser | p.I156S | O75431 | protein_coding | deleterious(0) | benign(0.103) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTX2 | SNV | Missense_Mutation | novel | c.293N>A | p.Ser98Tyr | p.S98Y | O75431 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
MTX2 | SNV | Missense_Mutation | novel | c.65C>T | p.Ala22Val | p.A22V | O75431 | protein_coding | tolerated(0.97) | benign(0.039) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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