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Gene: MTRNR2L1 |
Gene summary for MTRNR2L1 |
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Gene information | Species | Human | Gene symbol | MTRNR2L1 | Gene ID | 100462977 |
Gene name | MT-RNR2 like 1 | |
Gene Alias | HN1 | |
Cytomap | 17p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | P0CJ68 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100462977 | MTRNR2L1 | HCC1_Meng | Human | Liver | HCC | 4.78e-05 | -1.90e-01 | 0.0246 |
100462977 | MTRNR2L1 | HCC2_Meng | Human | Liver | HCC | 4.62e-37 | 2.94e-01 | 0.0107 |
100462977 | MTRNR2L1 | cirrhotic1 | Human | Liver | Cirrhotic | 8.96e-06 | 1.52e-01 | 0.0202 |
100462977 | MTRNR2L1 | cirrhotic2 | Human | Liver | Cirrhotic | 6.10e-24 | 5.20e-01 | 0.0201 |
100462977 | MTRNR2L1 | HCC1 | Human | Liver | HCC | 5.86e-59 | 7.50e+00 | 0.5336 |
100462977 | MTRNR2L1 | HCC2 | Human | Liver | HCC | 1.14e-07 | 7.94e-01 | 0.5341 |
100462977 | MTRNR2L1 | HCC5 | Human | Liver | HCC | 9.15e-40 | 1.35e+00 | 0.4932 |
100462977 | MTRNR2L1 | Pt13.a | Human | Liver | HCC | 1.07e-06 | -1.90e-01 | 0.021 |
100462977 | MTRNR2L1 | C04 | Human | Oral cavity | OSCC | 1.60e-13 | 3.62e-01 | 0.2633 |
100462977 | MTRNR2L1 | C30 | Human | Oral cavity | OSCC | 8.23e-53 | 2.09e+00 | 0.3055 |
100462977 | MTRNR2L1 | C46 | Human | Oral cavity | OSCC | 1.35e-03 | -6.74e-02 | 0.1673 |
100462977 | MTRNR2L1 | C08 | Human | Oral cavity | OSCC | 1.94e-17 | 4.35e-01 | 0.1919 |
100462977 | MTRNR2L1 | C86 | Human | Oral cavity | OSCC | 2.13e-05 | 1.03e+00 | 0.161 |
100462977 | MTRNR2L1 | LP17 | Human | Oral cavity | LP | 1.28e-02 | 1.48e-01 | 0.2349 |
100462977 | MTRNR2L1 | EOLP-1 | Human | Oral cavity | EOLP | 8.35e-04 | -1.54e-01 | -0.0202 |
100462977 | MTRNR2L1 | NEOLP-1 | Human | Oral cavity | NEOLP | 1.77e-03 | -1.54e-01 | -0.0194 |
100462977 | MTRNR2L1 | NEOLP-2 | Human | Oral cavity | NEOLP | 3.94e-04 | -1.54e-01 | -0.0196 |
100462977 | MTRNR2L1 | NEOLP-3 | Human | Oral cavity | NEOLP | 3.73e-03 | -1.54e-01 | -0.0191 |
100462977 | MTRNR2L1 | SYSMH1 | Human | Oral cavity | OSCC | 1.77e-03 | -1.54e-01 | 0.1127 |
100462977 | MTRNR2L1 | SYSMH2 | Human | Oral cavity | OSCC | 3.73e-03 | -1.54e-01 | 0.2326 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097194 | Liver | HCC | execution phase of apoptosis | 48/7958 | 85/18723 | 6.47e-03 | 2.63e-02 | 48 |
GO:1900117 | Liver | HCC | regulation of execution phase of apoptosis | 19/7958 | 29/18723 | 1.05e-02 | 3.89e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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