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Gene: MTIF3 |
Gene summary for MTIF3 |
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Gene information | Species | Human | Gene symbol | MTIF3 | Gene ID | 219402 |
Gene name | mitochondrial translational initiation factor 3 | |
Gene Alias | IF3mt | |
Cytomap | 13q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q9H2K0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
219402 | MTIF3 | P21T-E | Human | Esophagus | ESCC | 3.75e-40 | 6.37e-01 | 0.1617 |
219402 | MTIF3 | P22T-E | Human | Esophagus | ESCC | 5.91e-14 | 2.42e-01 | 0.1236 |
219402 | MTIF3 | P23T-E | Human | Esophagus | ESCC | 1.25e-27 | 6.61e-01 | 0.108 |
219402 | MTIF3 | P24T-E | Human | Esophagus | ESCC | 1.61e-29 | 4.81e-01 | 0.1287 |
219402 | MTIF3 | P26T-E | Human | Esophagus | ESCC | 2.85e-23 | 2.89e-01 | 0.1276 |
219402 | MTIF3 | P27T-E | Human | Esophagus | ESCC | 2.07e-21 | 3.88e-01 | 0.1055 |
219402 | MTIF3 | P28T-E | Human | Esophagus | ESCC | 5.12e-08 | 1.68e-01 | 0.1149 |
219402 | MTIF3 | P30T-E | Human | Esophagus | ESCC | 3.95e-21 | 8.88e-01 | 0.137 |
219402 | MTIF3 | P31T-E | Human | Esophagus | ESCC | 4.39e-29 | 1.98e-01 | 0.1251 |
219402 | MTIF3 | P32T-E | Human | Esophagus | ESCC | 1.22e-26 | 4.52e-01 | 0.1666 |
219402 | MTIF3 | P36T-E | Human | Esophagus | ESCC | 2.19e-09 | 3.94e-01 | 0.1187 |
219402 | MTIF3 | P37T-E | Human | Esophagus | ESCC | 4.00e-15 | 2.53e-01 | 0.1371 |
219402 | MTIF3 | P39T-E | Human | Esophagus | ESCC | 2.65e-15 | 2.26e-01 | 0.0894 |
219402 | MTIF3 | P40T-E | Human | Esophagus | ESCC | 1.08e-14 | 3.83e-01 | 0.109 |
219402 | MTIF3 | P42T-E | Human | Esophagus | ESCC | 5.44e-15 | 2.88e-01 | 0.1175 |
219402 | MTIF3 | P44T-E | Human | Esophagus | ESCC | 1.17e-10 | 1.79e-01 | 0.1096 |
219402 | MTIF3 | P47T-E | Human | Esophagus | ESCC | 3.32e-23 | 2.70e-01 | 0.1067 |
219402 | MTIF3 | P48T-E | Human | Esophagus | ESCC | 6.35e-17 | 1.88e-01 | 0.0959 |
219402 | MTIF3 | P49T-E | Human | Esophagus | ESCC | 1.34e-12 | 1.36e+00 | 0.1768 |
219402 | MTIF3 | P52T-E | Human | Esophagus | ESCC | 4.49e-18 | 2.98e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:0006413110 | Esophagus | ESCC | translational initiation | 100/8552 | 118/18723 | 1.16e-18 | 1.25e-16 | 100 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:190300816 | Esophagus | ESCC | organelle disassembly | 89/8552 | 114/18723 | 1.36e-12 | 5.80e-11 | 89 |
GO:000641312 | Liver | Cirrhotic | translational initiation | 76/4634 | 118/18723 | 8.36e-20 | 2.18e-17 | 76 |
GO:00224117 | Liver | Cirrhotic | cellular component disassembly | 182/4634 | 443/18723 | 1.59e-14 | 1.54e-12 | 182 |
GO:19030084 | Liver | Cirrhotic | organelle disassembly | 59/4634 | 114/18723 | 4.82e-10 | 2.27e-08 | 59 |
GO:0032543 | Liver | Cirrhotic | mitochondrial translation | 40/4634 | 76/18723 | 1.61e-07 | 4.29e-06 | 40 |
GO:0140053 | Liver | Cirrhotic | mitochondrial gene expression | 49/4634 | 108/18723 | 2.35e-06 | 4.31e-05 | 49 |
GO:002241112 | Liver | HCC | cellular component disassembly | 282/7958 | 443/18723 | 1.02e-19 | 1.38e-17 | 282 |
GO:000641322 | Liver | HCC | translational initiation | 94/7958 | 118/18723 | 1.39e-16 | 1.24e-14 | 94 |
GO:190300811 | Liver | HCC | organelle disassembly | 89/7958 | 114/18723 | 8.68e-15 | 5.73e-13 | 89 |
GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
GO:00325431 | Liver | HCC | mitochondrial translation | 62/7958 | 76/18723 | 2.95e-12 | 1.34e-10 | 62 |
GO:002241119 | Oral cavity | OSCC | cellular component disassembly | 283/7305 | 443/18723 | 9.57e-27 | 3.37e-24 | 283 |
GO:000641318 | Oral cavity | OSCC | translational initiation | 96/7305 | 118/18723 | 4.02e-21 | 7.06e-19 | 96 |
GO:19030088 | Oral cavity | OSCC | organelle disassembly | 85/7305 | 114/18723 | 1.15e-14 | 6.93e-13 | 85 |
GO:01400533 | Oral cavity | OSCC | mitochondrial gene expression | 78/7305 | 108/18723 | 2.37e-12 | 9.86e-11 | 78 |
GO:00325434 | Oral cavity | OSCC | mitochondrial translation | 59/7305 | 76/18723 | 7.21e-12 | 2.70e-10 | 59 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTIF3 | SNV | Missense_Mutation | c.93N>T | p.Lys31Asn | p.K31N | Q9H2K0 | protein_coding | tolerated(0.19) | benign(0.007) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
MTIF3 | deletion | In_Frame_Del | c.624_626delNNN | p.Ile209del | p.I209del | Q9H2K0 | protein_coding | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |||
MTIF3 | SNV | Missense_Mutation | novel | c.210N>T | p.Lys70Asn | p.K70N | Q9H2K0 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
MTIF3 | SNV | Missense_Mutation | c.473G>T | p.Arg158Ile | p.R158I | Q9H2K0 | protein_coding | tolerated(0.62) | benign(0) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MTIF3 | SNV | Missense_Mutation | rs777543756 | c.305G>A | p.Arg102Gln | p.R102Q | Q9H2K0 | protein_coding | deleterious(0.02) | possibly_damaging(0.796) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MTIF3 | SNV | Missense_Mutation | novel | c.388N>T | p.Leu130Phe | p.L130F | Q9H2K0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
MTIF3 | SNV | Missense_Mutation | c.824N>C | p.Val275Ala | p.V275A | Q9H2K0 | protein_coding | tolerated(0.47) | benign(0) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
MTIF3 | SNV | Missense_Mutation | rs150437746 | c.254N>A | p.Arg85Gln | p.R85Q | Q9H2K0 | protein_coding | tolerated(0.05) | probably_damaging(0.993) | TCGA-B5-A0K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
MTIF3 | SNV | Missense_Mutation | novel | c.679N>T | p.Pro227Ser | p.P227S | Q9H2K0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MTIF3 | SNV | Missense_Mutation | novel | c.245N>A | p.Ile82Asn | p.I82N | Q9H2K0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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