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Gene: MTF1 |
Gene summary for MTF1 |
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Gene information | Species | Human | Gene symbol | MTF1 | Gene ID | 4520 |
Gene name | metal regulatory transcription factor 1 | |
Gene Alias | MTF-1 | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | Q14872 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4520 | MTF1 | P24T-E | Human | Esophagus | ESCC | 1.62e-05 | 9.24e-02 | 0.1287 |
4520 | MTF1 | P26T-E | Human | Esophagus | ESCC | 7.40e-17 | 2.45e-01 | 0.1276 |
4520 | MTF1 | P27T-E | Human | Esophagus | ESCC | 1.89e-12 | 2.84e-01 | 0.1055 |
4520 | MTF1 | P28T-E | Human | Esophagus | ESCC | 1.30e-17 | 3.37e-01 | 0.1149 |
4520 | MTF1 | P30T-E | Human | Esophagus | ESCC | 6.63e-13 | 3.33e-01 | 0.137 |
4520 | MTF1 | P31T-E | Human | Esophagus | ESCC | 2.18e-08 | 2.44e-01 | 0.1251 |
4520 | MTF1 | P32T-E | Human | Esophagus | ESCC | 1.75e-09 | 1.73e-01 | 0.1666 |
4520 | MTF1 | P36T-E | Human | Esophagus | ESCC | 9.74e-05 | 2.04e-01 | 0.1187 |
4520 | MTF1 | P37T-E | Human | Esophagus | ESCC | 9.51e-11 | 2.00e-01 | 0.1371 |
4520 | MTF1 | P39T-E | Human | Esophagus | ESCC | 4.60e-13 | 2.27e-01 | 0.0894 |
4520 | MTF1 | P40T-E | Human | Esophagus | ESCC | 4.38e-02 | 6.10e-02 | 0.109 |
4520 | MTF1 | P42T-E | Human | Esophagus | ESCC | 2.86e-05 | 2.19e-01 | 0.1175 |
4520 | MTF1 | P44T-E | Human | Esophagus | ESCC | 7.29e-03 | 8.57e-02 | 0.1096 |
4520 | MTF1 | P47T-E | Human | Esophagus | ESCC | 8.46e-10 | 1.19e-01 | 0.1067 |
4520 | MTF1 | P48T-E | Human | Esophagus | ESCC | 1.81e-10 | 1.98e-01 | 0.0959 |
4520 | MTF1 | P49T-E | Human | Esophagus | ESCC | 6.30e-03 | 3.35e-01 | 0.1768 |
4520 | MTF1 | P52T-E | Human | Esophagus | ESCC | 4.67e-15 | 3.42e-01 | 0.1555 |
4520 | MTF1 | P54T-E | Human | Esophagus | ESCC | 2.44e-15 | 3.47e-01 | 0.0975 |
4520 | MTF1 | P56T-E | Human | Esophagus | ESCC | 6.64e-09 | 6.67e-01 | 0.1613 |
4520 | MTF1 | P57T-E | Human | Esophagus | ESCC | 8.25e-08 | 1.87e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697927 | Esophagus | HGIN | response to oxidative stress | 107/2587 | 446/18723 | 3.91e-09 | 2.76e-07 | 107 |
GO:004668618 | Esophagus | HGIN | response to cadmium ion | 20/2587 | 68/18723 | 6.35e-04 | 8.73e-03 | 20 |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:001003827 | Esophagus | ESCC | response to metal ion | 208/8552 | 373/18723 | 5.02e-05 | 3.90e-04 | 208 |
GO:004668619 | Esophagus | ESCC | response to cadmium ion | 47/8552 | 68/18723 | 7.81e-05 | 5.80e-04 | 47 |
GO:007124117 | Esophagus | ESCC | cellular response to inorganic substance | 125/8552 | 226/18723 | 2.17e-03 | 9.67e-03 | 125 |
GO:000697922 | Liver | HCC | response to oxidative stress | 281/7958 | 446/18723 | 9.75e-19 | 1.24e-16 | 281 |
GO:001003822 | Liver | HCC | response to metal ion | 208/7958 | 373/18723 | 1.35e-07 | 2.56e-06 | 208 |
GO:004668622 | Liver | HCC | response to cadmium ion | 47/7958 | 68/18723 | 8.13e-06 | 9.56e-05 | 47 |
GO:007124112 | Liver | HCC | cellular response to inorganic substance | 119/7958 | 226/18723 | 1.26e-03 | 6.92e-03 | 119 |
GO:007124812 | Liver | HCC | cellular response to metal ion | 101/7958 | 197/18723 | 7.82e-03 | 3.10e-02 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTF1 | SNV | Missense_Mutation | novel | c.1845G>T | p.Gln615His | p.Q615H | Q14872 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A2-A0ER-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
MTF1 | SNV | Missense_Mutation | c.841C>T | p.Arg281Cys | p.R281C | Q14872 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTF1 | SNV | Missense_Mutation | rs779682329 | c.752G>A | p.Arg251Gln | p.R251Q | Q14872 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MTF1 | SNV | Missense_Mutation | novel | c.2060N>T | p.Ser687Leu | p.S687L | Q14872 | protein_coding | tolerated_low_confidence(0.25) | benign(0.015) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
MTF1 | SNV | Missense_Mutation | c.1070N>T | p.Thr357Ile | p.T357I | Q14872 | protein_coding | deleterious(0.03) | benign(0.024) | TCGA-BH-A0E7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
MTF1 | SNV | Missense_Mutation | c.245A>T | p.His82Leu | p.H82L | Q14872 | protein_coding | tolerated(0.71) | benign(0) | TCGA-EW-A1P8-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | PD | |
MTF1 | SNV | Missense_Mutation | c.193G>A | p.Gly65Arg | p.G65R | Q14872 | protein_coding | deleterious(0.01) | benign(0.03) | TCGA-EW-A6SC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | aromatase | SD | |
MTF1 | insertion | Nonsense_Mutation | novel | c.508_509insGGCCTATTCAGTAGCCAATTCTCTTTTTCACGTTTGTATCAGG | p.Phe170TrpfsTer5 | p.F170Wfs*5 | Q14872 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
MTF1 | insertion | In_Frame_Ins | novel | c.1845_1846insAAT | p.Gln615_Gln616insAsn | p.Q615_Q616insN | Q14872 | protein_coding | TCGA-A8-A0A9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | ||
MTF1 | insertion | Frame_Shift_Ins | novel | c.1844_1845insATGG | p.Gln616TrpfsTer53 | p.Q616Wfs*53 | Q14872 | protein_coding | TCGA-A8-A0A9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4520 | MTF1 | TRANSCRIPTION FACTOR | LOR-253 | APTO-253 |
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