![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MSANTD3 |
Gene summary for MSANTD3 |
![]() |
Gene information | Species | Human | Gene symbol | MSANTD3 | Gene ID | 91283 |
Gene name | Myb/SANT DNA binding domain containing 3 | |
Gene Alias | C9orf30 | |
Cytomap | 9q31.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024R171 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91283 | MSANTD3 | P17T-E | Human | Esophagus | ESCC | 5.27e-06 | 2.22e-01 | 0.1278 |
91283 | MSANTD3 | P19T-E | Human | Esophagus | ESCC | 7.04e-10 | 5.90e-01 | 0.1662 |
91283 | MSANTD3 | P20T-E | Human | Esophagus | ESCC | 4.39e-04 | 1.07e-01 | 0.1124 |
91283 | MSANTD3 | P21T-E | Human | Esophagus | ESCC | 1.54e-23 | 4.05e-01 | 0.1617 |
91283 | MSANTD3 | P22T-E | Human | Esophagus | ESCC | 3.17e-12 | 1.91e-01 | 0.1236 |
91283 | MSANTD3 | P23T-E | Human | Esophagus | ESCC | 2.47e-11 | 2.03e-01 | 0.108 |
91283 | MSANTD3 | P24T-E | Human | Esophagus | ESCC | 1.73e-19 | 4.97e-01 | 0.1287 |
91283 | MSANTD3 | P26T-E | Human | Esophagus | ESCC | 1.03e-10 | 2.26e-01 | 0.1276 |
91283 | MSANTD3 | P27T-E | Human | Esophagus | ESCC | 1.87e-09 | 5.73e-02 | 0.1055 |
91283 | MSANTD3 | P28T-E | Human | Esophagus | ESCC | 6.13e-16 | 3.23e-01 | 0.1149 |
91283 | MSANTD3 | P30T-E | Human | Esophagus | ESCC | 1.06e-14 | 5.13e-01 | 0.137 |
91283 | MSANTD3 | P31T-E | Human | Esophagus | ESCC | 6.46e-14 | 3.46e-01 | 0.1251 |
91283 | MSANTD3 | P32T-E | Human | Esophagus | ESCC | 6.33e-41 | 8.88e-01 | 0.1666 |
91283 | MSANTD3 | P36T-E | Human | Esophagus | ESCC | 9.33e-09 | 3.89e-01 | 0.1187 |
91283 | MSANTD3 | P37T-E | Human | Esophagus | ESCC | 7.94e-10 | 1.77e-01 | 0.1371 |
91283 | MSANTD3 | P38T-E | Human | Esophagus | ESCC | 3.24e-16 | 8.14e-01 | 0.127 |
91283 | MSANTD3 | P39T-E | Human | Esophagus | ESCC | 4.52e-03 | 2.57e-02 | 0.0894 |
91283 | MSANTD3 | P40T-E | Human | Esophagus | ESCC | 5.80e-19 | 5.00e-01 | 0.109 |
91283 | MSANTD3 | P42T-E | Human | Esophagus | ESCC | 2.69e-13 | 2.72e-01 | 0.1175 |
91283 | MSANTD3 | P44T-E | Human | Esophagus | ESCC | 1.68e-05 | 1.57e-01 | 0.1096 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MSANTD3 | SNV | Missense_Mutation | novel | c.163N>A | p.Glu55Lys | p.E55K | Q96H12 | protein_coding | tolerated(0.08) | possibly_damaging(0.671) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MSANTD3 | SNV | Missense_Mutation | rs773424982 | c.173C>T | p.Ser58Phe | p.S58F | Q96H12 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-E2-A14X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
MSANTD3 | SNV | Missense_Mutation | c.401N>A | p.Pro134His | p.P134H | Q96H12 | protein_coding | tolerated_low_confidence(0.12) | benign(0) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MSANTD3 | SNV | Missense_Mutation | novel | c.194N>A | p.Arg65Gln | p.R65Q | Q96H12 | protein_coding | deleterious(0.01) | possibly_damaging(0.48) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MSANTD3 | SNV | Missense_Mutation | rs533234800 | c.13N>A | p.Glu5Lys | p.E5K | Q96H12 | protein_coding | tolerated_low_confidence(0.09) | possibly_damaging(0.905) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
MSANTD3 | SNV | Missense_Mutation | c.91N>A | p.Val31Met | p.V31M | Q96H12 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MSANTD3 | SNV | Missense_Mutation | rs367876098 | c.451N>A | p.Asp151Asn | p.D151N | Q96H12 | protein_coding | deleterious_low_confidence(0) | benign(0.021) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MSANTD3 | SNV | Missense_Mutation | rs776217356 | c.406G>A | p.Ala136Thr | p.A136T | Q96H12 | protein_coding | tolerated_low_confidence(0.09) | benign(0) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MSANTD3 | SNV | Missense_Mutation | rs750365142 | c.283N>T | p.Arg95Trp | p.R95W | Q96H12 | protein_coding | deleterious(0.02) | benign(0.265) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MSANTD3 | SNV | Missense_Mutation | rs367876098 | c.451N>A | p.Asp151Asn | p.D151N | Q96H12 | protein_coding | deleterious_low_confidence(0) | benign(0.021) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |