Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MRPS33

Gene summary for MRPS33

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MRPS33

Gene ID

51650

Gene namemitochondrial ribosomal protein S33
Gene AliasCGI-139
Cytomap7q34
Gene Typeprotein-coding
GO ID

GO:0006412

UniProtAcc

A4D1T3


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
51650MRPS33HTA11_99999965104_69814HumanColorectumMSS4.09e-116.42e-010.281
51650MRPS33HTA11_99999971662_82457HumanColorectumMSS2.30e-206.98e-010.3859
51650MRPS33HTA11_99999974143_84620HumanColorectumMSS7.28e-144.77e-010.3005
51650MRPS33LZE4THumanEsophagusESCC3.31e-102.18e-010.0811
51650MRPS33LZE5THumanEsophagusESCC1.35e-021.77e-010.0514
51650MRPS33LZE7THumanEsophagusESCC2.05e-056.47e-010.0667
51650MRPS33LZE8THumanEsophagusESCC1.89e-033.30e-010.067
51650MRPS33LZE20THumanEsophagusESCC1.47e-064.38e-010.0662
51650MRPS33LZE22D1HumanEsophagusHGIN9.51e-051.37e-010.0595
51650MRPS33LZE24THumanEsophagusESCC8.02e-065.92e-010.0596
51650MRPS33LZE6THumanEsophagusESCC7.93e-044.08e-010.0845
51650MRPS33P1T-EHumanEsophagusESCC5.72e-104.48e-010.0875
51650MRPS33P2T-EHumanEsophagusESCC7.46e-174.07e-010.1177
51650MRPS33P4T-EHumanEsophagusESCC2.25e-521.54e+000.1323
51650MRPS33P5T-EHumanEsophagusESCC2.03e-501.16e+000.1327
51650MRPS33P8T-EHumanEsophagusESCC1.06e-245.54e-010.0889
51650MRPS33P9T-EHumanEsophagusESCC1.44e-228.71e-010.1131
51650MRPS33P10T-EHumanEsophagusESCC2.28e-356.39e-010.116
51650MRPS33P11T-EHumanEsophagusESCC9.34e-083.08e-010.1426
51650MRPS33P12T-EHumanEsophagusESCC3.56e-591.27e+000.1122
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MRPS33SNVMissense_Mutationc.302N>Cp.Arg101Thrp.R101TQ9Y291protein_codingdeleterious(0)probably_damaging(0.991)TCGA-C8-A275-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
MRPS33SNVMissense_Mutationrs779139791c.50N>Ap.Arg17Glnp.R17QQ9Y291protein_codingtolerated(0.12)benign(0.173)TCGA-C5-A3HE-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownPD
MRPS33deletionFrame_Shift_Delc.301delAp.Arg101GlufsTer55p.R101Efs*55Q9Y291protein_codingTCGA-G4-6302-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
MRPS33SNVMissense_Mutationnovelc.71G>Tp.Arg24Metp.R24MQ9Y291protein_codingdeleterious(0.03)probably_damaging(0.945)TCGA-A5-A0G1-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MRPS33SNVMissense_Mutationc.280N>Tp.Pro94Serp.P94SQ9Y291protein_codingdeleterious(0.01)probably_damaging(0.999)TCGA-BS-A0TJ-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
MRPS33deletionFrame_Shift_Delc.301delNp.Arg101GlufsTer55p.R101Efs*55Q9Y291protein_codingTCGA-D1-A17M-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
MRPS33deletionFrame_Shift_Delnovelc.223delNp.His75IlefsTer11p.H75Ifs*11Q9Y291protein_codingTCGA-EO-A22U-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MRPS33deletionFrame_Shift_Delnovelc.313delAp.Arg105GlyfsTer51p.R105Gfs*51Q9Y291protein_codingTCGA-EY-A1GK-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MRPS33SNVMissense_Mutationc.203N>Cp.Leu68Prop.L68PQ9Y291protein_codingdeleterious(0.01)possibly_damaging(0.892)TCGA-DD-A1EK-01Liverliver hepatocellular carcinomaFemale<65I/IITargeted Molecular therapysorafenibPD
MRPS33SNVMissense_Mutationrs750148841c.304N>Tp.Ala102Serp.A102SQ9Y291protein_codingtolerated(0.33)benign(0.033)TCGA-95-7567-01Lunglung adenocarcinomaMale<65I/IIChemotherapycisplatinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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