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Gene: MRPS22 |
Gene summary for MRPS22 |
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Gene information | Species | Human | Gene symbol | MRPS22 | Gene ID | 56945 |
Gene name | mitochondrial ribosomal protein S22 | |
Gene Alias | C3orf5 | |
Cytomap | 3q23 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P82650 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56945 | MRPS22 | P17T-E | Human | Esophagus | ESCC | 2.77e-08 | 4.99e-01 | 0.1278 |
56945 | MRPS22 | P19T-E | Human | Esophagus | ESCC | 1.10e-04 | 6.79e-01 | 0.1662 |
56945 | MRPS22 | P20T-E | Human | Esophagus | ESCC | 1.06e-37 | 7.64e-01 | 0.1124 |
56945 | MRPS22 | P21T-E | Human | Esophagus | ESCC | 3.06e-49 | 1.00e+00 | 0.1617 |
56945 | MRPS22 | P22T-E | Human | Esophagus | ESCC | 3.09e-41 | 7.53e-01 | 0.1236 |
56945 | MRPS22 | P23T-E | Human | Esophagus | ESCC | 1.69e-35 | 9.96e-01 | 0.108 |
56945 | MRPS22 | P24T-E | Human | Esophagus | ESCC | 1.30e-37 | 7.99e-01 | 0.1287 |
56945 | MRPS22 | P26T-E | Human | Esophagus | ESCC | 5.54e-54 | 9.55e-01 | 0.1276 |
56945 | MRPS22 | P27T-E | Human | Esophagus | ESCC | 6.36e-33 | 6.47e-01 | 0.1055 |
56945 | MRPS22 | P28T-E | Human | Esophagus | ESCC | 2.69e-46 | 9.15e-01 | 0.1149 |
56945 | MRPS22 | P30T-E | Human | Esophagus | ESCC | 6.65e-32 | 1.08e+00 | 0.137 |
56945 | MRPS22 | P31T-E | Human | Esophagus | ESCC | 1.38e-52 | 8.19e-01 | 0.1251 |
56945 | MRPS22 | P32T-E | Human | Esophagus | ESCC | 1.19e-32 | 7.01e-01 | 0.1666 |
56945 | MRPS22 | P36T-E | Human | Esophagus | ESCC | 5.87e-22 | 4.69e-01 | 0.1187 |
56945 | MRPS22 | P37T-E | Human | Esophagus | ESCC | 6.54e-30 | 6.15e-01 | 0.1371 |
56945 | MRPS22 | P38T-E | Human | Esophagus | ESCC | 5.03e-13 | 5.86e-01 | 0.127 |
56945 | MRPS22 | P39T-E | Human | Esophagus | ESCC | 1.00e-26 | 5.60e-01 | 0.0894 |
56945 | MRPS22 | P40T-E | Human | Esophagus | ESCC | 1.53e-21 | 5.18e-01 | 0.109 |
56945 | MRPS22 | P42T-E | Human | Esophagus | ESCC | 3.30e-22 | 5.92e-01 | 0.1175 |
56945 | MRPS22 | P44T-E | Human | Esophagus | ESCC | 1.23e-15 | 3.54e-01 | 0.1096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPS22 | SNV | Missense_Mutation | c.808G>C | p.Gly270Arg | p.G270R | P82650 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
MRPS22 | SNV | Missense_Mutation | c.619N>G | p.Pro207Ala | p.P207A | P82650 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
MRPS22 | SNV | Missense_Mutation | novel | c.107T>C | p.Leu36Pro | p.L36P | P82650 | protein_coding | deleterious_low_confidence(0.03) | benign(0.003) | TCGA-B6-A40B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPS22 | SNV | Missense_Mutation | c.913N>G | p.His305Asp | p.H305D | P82650 | protein_coding | deleterious(0.04) | possibly_damaging(0.897) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MRPS22 | SNV | Missense_Mutation | c.217N>A | p.Glu73Lys | p.E73K | P82650 | protein_coding | tolerated(0.16) | benign(0.017) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
MRPS22 | SNV | Missense_Mutation | novel | c.28C>A | p.Leu10Met | p.L10M | P82650 | protein_coding | deleterious_low_confidence(0.03) | benign(0.01) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MRPS22 | SNV | Missense_Mutation | c.132N>G | p.Phe44Leu | p.F44L | P82650 | protein_coding | tolerated_low_confidence(0.81) | benign(0) | TCGA-EK-A2RO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MRPS22 | SNV | Missense_Mutation | novel | c.562N>A | p.Glu188Lys | p.E188K | P82650 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VS-A954-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
MRPS22 | SNV | Missense_Mutation | rs773327850 | c.976N>C | p.Asn326His | p.N326H | P82650 | protein_coding | tolerated(0.14) | benign(0.001) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MRPS22 | SNV | Missense_Mutation | rs755925113 | c.1064G>A | p.Arg355His | p.R355H | P82650 | protein_coding | deleterious(0.01) | benign(0.042) | TCGA-DM-A282-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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