|
Gene: MRPL55 |
Gene summary for MRPL55 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MRPL55 | Gene ID | 128308 |
Gene name | mitochondrial ribosomal protein L55 | |
Gene Alias | AAVG5835 | |
Cytomap | 1q42.13 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | A0A024R3R0 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
128308 | MRPL55 | GSM4909313 | Human | Breast | IDC | 1.60e-06 | 2.31e-01 | 0.0391 |
128308 | MRPL55 | GSM4909315 | Human | Breast | IDC | 1.38e-05 | 3.81e-01 | 0.21 |
128308 | MRPL55 | GSM4909316 | Human | Breast | IDC | 5.24e-05 | 3.69e-01 | 0.21 |
128308 | MRPL55 | GSM4909317 | Human | Breast | IDC | 2.39e-04 | 2.82e-01 | 0.1355 |
128308 | MRPL55 | GSM4909318 | Human | Breast | IDC | 2.82e-04 | 3.38e-01 | 0.2031 |
128308 | MRPL55 | GSM4909319 | Human | Breast | IDC | 6.57e-31 | 9.55e-02 | 0.1563 |
128308 | MRPL55 | GSM4909320 | Human | Breast | IDC | 4.83e-11 | 3.78e-01 | 0.1575 |
128308 | MRPL55 | GSM4909321 | Human | Breast | IDC | 1.39e-23 | 4.94e-01 | 0.1559 |
128308 | MRPL55 | brca2 | Human | Breast | Precancer | 1.97e-05 | 1.63e-01 | -0.024 |
128308 | MRPL55 | M2 | Human | Breast | IDC | 1.40e-03 | 1.96e-01 | 0.21 |
128308 | MRPL55 | NCCBC14 | Human | Breast | DCIS | 1.72e-11 | 2.12e-01 | 0.2021 |
128308 | MRPL55 | NCCBC5 | Human | Breast | DCIS | 9.50e-09 | 1.29e-01 | 0.2046 |
128308 | MRPL55 | P1 | Human | Breast | IDC | 2.27e-07 | -1.54e-01 | 0.1527 |
128308 | MRPL55 | P2 | Human | Breast | IDC | 3.33e-04 | 2.85e-01 | 0.21 |
128308 | MRPL55 | DCIS2 | Human | Breast | DCIS | 9.24e-39 | 2.36e-02 | 0.0085 |
128308 | MRPL55 | LZE2T | Human | Esophagus | ESCC | 4.88e-02 | 8.78e-01 | 0.082 |
128308 | MRPL55 | LZE4T | Human | Esophagus | ESCC | 7.88e-05 | 2.85e-01 | 0.0811 |
128308 | MRPL55 | LZE7T | Human | Esophagus | ESCC | 9.45e-14 | 1.23e+00 | 0.0667 |
128308 | MRPL55 | LZE8T | Human | Esophagus | ESCC | 5.49e-09 | 3.03e-01 | 0.067 |
128308 | MRPL55 | LZE20T | Human | Esophagus | ESCC | 6.32e-03 | 3.55e-01 | 0.0662 |
Page: 1 2 3 4 5 6 7 8 9 10 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL55 | SNV | Missense_Mutation | novel | c.163A>G | p.Thr55Ala | p.T55A | Q7Z7F7 | protein_coding | tolerated(0.57) | benign(0.003) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL55 | SNV | Missense_Mutation | novel | c.109T>C | p.Cys37Arg | p.C37R | Q7Z7F7 | protein_coding | deleterious_low_confidence(0.01) | benign(0.136) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL55 | SNV | Missense_Mutation | rs758299560 | c.460N>T | p.Arg154Cys | p.R154C | Q7Z7F7 | protein_coding | deleterious(0) | possibly_damaging(0.804) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
MRPL55 | SNV | Missense_Mutation | c.187C>T | p.His63Tyr | p.H63Y | Q7Z7F7 | protein_coding | tolerated(0.06) | benign(0.135) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
MRPL55 | SNV | Missense_Mutation | rs376021962 | c.377N>A | p.Arg126Gln | p.R126Q | Q7Z7F7 | protein_coding | tolerated(0.1) | possibly_damaging(0.873) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MRPL55 | SNV | Missense_Mutation | novel | c.451C>T | p.His151Tyr | p.H151Y | Q7Z7F7 | protein_coding | deleterious(0.03) | benign(0.182) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL55 | SNV | Missense_Mutation | rs766879446 | c.166G>A | p.Gly56Arg | p.G56R | Q7Z7F7 | protein_coding | tolerated(0.31) | benign(0.114) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
MRPL55 | SNV | Missense_Mutation | novel | c.455T>C | p.Val152Ala | p.V152A | Q7Z7F7 | protein_coding | tolerated(0.52) | benign(0.051) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MRPL55 | SNV | Missense_Mutation | rs751426782 | c.394C>T | p.Arg132Cys | p.R132C | Q7Z7F7 | protein_coding | deleterious(0.02) | benign(0.267) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL55 | SNV | Missense_Mutation | novel | c.365C>A | p.Pro122His | p.P122H | Q7Z7F7 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |