![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MRPL22 |
Gene summary for MRPL22 |
![]() |
Gene information | Species | Human | Gene symbol | MRPL22 | Gene ID | 29093 |
Gene name | mitochondrial ribosomal protein L22 | |
Gene Alias | HSPC158 | |
Cytomap | 5q33.2 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q9NWU5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29093 | MRPL22 | P20T-E | Human | Esophagus | ESCC | 3.90e-26 | 6.95e-01 | 0.1124 |
29093 | MRPL22 | P21T-E | Human | Esophagus | ESCC | 3.31e-51 | 1.16e+00 | 0.1617 |
29093 | MRPL22 | P22T-E | Human | Esophagus | ESCC | 7.30e-44 | 8.39e-01 | 0.1236 |
29093 | MRPL22 | P23T-E | Human | Esophagus | ESCC | 1.42e-37 | 1.07e+00 | 0.108 |
29093 | MRPL22 | P24T-E | Human | Esophagus | ESCC | 5.12e-31 | 7.22e-01 | 0.1287 |
29093 | MRPL22 | P26T-E | Human | Esophagus | ESCC | 5.56e-30 | 7.25e-01 | 0.1276 |
29093 | MRPL22 | P27T-E | Human | Esophagus | ESCC | 6.01e-26 | 5.39e-01 | 0.1055 |
29093 | MRPL22 | P28T-E | Human | Esophagus | ESCC | 2.02e-32 | 6.89e-01 | 0.1149 |
29093 | MRPL22 | P30T-E | Human | Esophagus | ESCC | 1.73e-21 | 9.65e-01 | 0.137 |
29093 | MRPL22 | P31T-E | Human | Esophagus | ESCC | 1.09e-30 | 6.00e-01 | 0.1251 |
29093 | MRPL22 | P32T-E | Human | Esophagus | ESCC | 1.22e-73 | 1.71e+00 | 0.1666 |
29093 | MRPL22 | P36T-E | Human | Esophagus | ESCC | 8.67e-21 | 6.99e-01 | 0.1187 |
29093 | MRPL22 | P37T-E | Human | Esophagus | ESCC | 5.05e-22 | 5.69e-01 | 0.1371 |
29093 | MRPL22 | P38T-E | Human | Esophagus | ESCC | 1.36e-16 | 9.61e-01 | 0.127 |
29093 | MRPL22 | P39T-E | Human | Esophagus | ESCC | 5.00e-12 | 3.81e-01 | 0.0894 |
29093 | MRPL22 | P40T-E | Human | Esophagus | ESCC | 2.23e-10 | 4.31e-01 | 0.109 |
29093 | MRPL22 | P42T-E | Human | Esophagus | ESCC | 4.21e-19 | 5.83e-01 | 0.1175 |
29093 | MRPL22 | P44T-E | Human | Esophagus | ESCC | 8.57e-14 | 5.34e-01 | 0.1096 |
29093 | MRPL22 | P47T-E | Human | Esophagus | ESCC | 4.24e-16 | 2.65e-01 | 0.1067 |
29093 | MRPL22 | P48T-E | Human | Esophagus | ESCC | 1.37e-24 | 4.12e-01 | 0.0959 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:0042255111 | Esophagus | ESCC | ribosome assembly | 50/8552 | 61/18723 | 5.66e-09 | 1.17e-07 | 50 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:004225512 | Liver | Cirrhotic | ribosome assembly | 39/4634 | 61/18723 | 1.07e-10 | 5.72e-09 | 39 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:004225522 | Liver | HCC | ribosome assembly | 50/7958 | 61/18723 | 2.79e-10 | 9.50e-09 | 50 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:004225520 | Oral cavity | OSCC | ribosome assembly | 49/7305 | 61/18723 | 4.73e-11 | 1.50e-09 | 49 |
GO:0022613110 | Oral cavity | LP | ribonucleoprotein complex biogenesis | 259/4623 | 463/18723 | 7.20e-48 | 2.25e-44 | 259 |
GO:0042254110 | Oral cavity | LP | ribosome biogenesis | 173/4623 | 299/18723 | 8.97e-35 | 1.41e-31 | 173 |
GO:0042255110 | Oral cavity | LP | ribosome assembly | 44/4623 | 61/18723 | 8.20e-15 | 1.05e-12 | 44 |
GO:002261329 | Skin | cSCC | ribonucleoprotein complex biogenesis | 302/4864 | 463/18723 | 5.13e-72 | 3.22e-68 | 302 |
GO:004225428 | Skin | cSCC | ribosome biogenesis | 206/4864 | 299/18723 | 3.33e-55 | 1.04e-51 | 206 |
GO:004225529 | Skin | cSCC | ribosome assembly | 44/4864 | 61/18723 | 5.84e-14 | 3.81e-12 | 44 |
GO:0022613113 | Thyroid | PTC | ribonucleoprotein complex biogenesis | 292/5968 | 463/18723 | 3.24e-44 | 2.05e-40 | 292 |
GO:0042254113 | Thyroid | PTC | ribosome biogenesis | 202/5968 | 299/18723 | 3.47e-37 | 5.47e-34 | 202 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301042 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301052 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301030 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010114 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010210 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
hsa0301038 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL22 | SNV | Missense_Mutation | novel | c.223A>C | p.Lys75Gln | p.K75Q | Q9NWU5 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-OL-A66P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
MRPL22 | insertion | In_Frame_Ins | novel | c.494_495insCTTCCGAACAAGCCCAGTGCCTGC | p.Tyr165_Cys166insPheArgThrSerProValProAla | p.Y165_C166insFRTSPVPA | Q9NWU5 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
MRPL22 | SNV | Missense_Mutation | novel | c.172C>T | p.Pro58Ser | p.P58S | Q9NWU5 | protein_coding | deleterious(0.02) | benign(0.175) | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
MRPL22 | SNV | Missense_Mutation | c.132N>C | p.Lys44Asn | p.K44N | Q9NWU5 | protein_coding | tolerated(0.17) | benign(0.005) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
MRPL22 | SNV | Missense_Mutation | novel | c.231N>G | p.Ser77Arg | p.S77R | Q9NWU5 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-MU-A8JM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL22 | SNV | Missense_Mutation | novel | c.161N>T | p.Pro54Leu | p.P54L | Q9NWU5 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-PN-A8MA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
MRPL22 | insertion | Frame_Shift_Ins | novel | c.171_172insGAAATAT | p.Pro58GlufsTer22 | p.P58Efs*22 | Q9NWU5 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
MRPL22 | SNV | Missense_Mutation | rs763635105 | c.446N>A | p.Arg149His | p.R149H | Q9NWU5 | protein_coding | tolerated(0.11) | probably_damaging(0.967) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MRPL22 | SNV | Missense_Mutation | c.593G>A | p.Arg198His | p.R198H | Q9NWU5 | protein_coding | tolerated(0.06) | possibly_damaging(0.773) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
MRPL22 | SNV | Missense_Mutation | rs200057403 | c.128G>A | p.Arg43Gln | p.R43Q | Q9NWU5 | protein_coding | tolerated(0.21) | benign(0.005) | TCGA-AJ-A8CV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |