Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: MLLT4

Gene summary for MLLT4

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MLLT4

Gene ID

4301

Gene nameafadin, adherens junction formation factor
Gene AliasAF6
Cytomap6q27
Gene Typeprotein-coding
GO ID

GO:0001885

UniProtAcc

P55196


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4301MLLT4P22T-EHumanEsophagusESCC3.60e-132.61e-010.1236
4301MLLT4P23T-EHumanEsophagusESCC4.96e-266.20e-010.108
4301MLLT4P24T-EHumanEsophagusESCC1.85e-184.68e-010.1287
4301MLLT4P26T-EHumanEsophagusESCC6.89e-447.24e-010.1276
4301MLLT4P27T-EHumanEsophagusESCC1.85e-183.76e-010.1055
4301MLLT4P28T-EHumanEsophagusESCC1.72e-549.61e-010.1149
4301MLLT4P30T-EHumanEsophagusESCC4.37e-205.05e-010.137
4301MLLT4P31T-EHumanEsophagusESCC1.97e-102.23e-010.1251
4301MLLT4P32T-EHumanEsophagusESCC1.13e-162.93e-010.1666
4301MLLT4P36T-EHumanEsophagusESCC1.14e-175.12e-010.1187
4301MLLT4P37T-EHumanEsophagusESCC9.95e-305.37e-010.1371
4301MLLT4P38T-EHumanEsophagusESCC4.54e-113.85e-010.127
4301MLLT4P39T-EHumanEsophagusESCC8.96e-458.08e-010.0894
4301MLLT4P40T-EHumanEsophagusESCC1.39e-204.74e-010.109
4301MLLT4P42T-EHumanEsophagusESCC3.60e-122.82e-010.1175
4301MLLT4P44T-EHumanEsophagusESCC2.31e-164.39e-010.1096
4301MLLT4P47T-EHumanEsophagusESCC1.62e-132.36e-010.1067
4301MLLT4P48T-EHumanEsophagusESCC5.95e-294.88e-010.0959
4301MLLT4P49T-EHumanEsophagusESCC3.28e-159.80e-010.1768
4301MLLT4P52T-EHumanEsophagusESCC1.49e-396.16e-010.1555
Page: 1 2 3 4 5 6 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
Page: 1 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0452020CervixCCAdherens junction33/126793/84656.99e-077.31e-064.32e-0633
hsa0453020CervixCCTight junction49/1267169/84651.87e-061.78e-051.05e-0549
hsa0467020CervixCCLeukocyte transendothelial migration36/1267114/84655.22e-064.83e-052.86e-0536
hsa0401512CervixCCRap1 signaling pathway56/1267210/84656.23e-065.61e-053.32e-0556
hsa040142CervixCCRas signaling pathway51/1267236/84653.55e-031.34e-027.91e-0351
hsa04520110CervixCCAdherens junction33/126793/84656.99e-077.31e-064.32e-0633
hsa04530110CervixCCTight junction49/1267169/84651.87e-061.78e-051.05e-0549
hsa04670110CervixCCLeukocyte transendothelial migration36/1267114/84655.22e-064.83e-052.86e-0536
hsa0401513CervixCCRap1 signaling pathway56/1267210/84656.23e-065.61e-053.32e-0556
hsa0401411CervixCCRas signaling pathway51/1267236/84653.55e-031.34e-027.91e-0351
hsa0467025CervixHSIL_HPVLeukocyte transendothelial migration16/459114/84654.04e-043.49e-032.82e-0316
hsa0467035CervixHSIL_HPVLeukocyte transendothelial migration16/459114/84654.04e-043.49e-032.82e-0316
hsa04520ColorectumADAdherens junction50/209293/84651.52e-092.83e-081.81e-0850
hsa04530ColorectumADTight junction76/2092169/84655.49e-099.69e-086.18e-0876
hsa04015ColorectumADRap1 signaling pathway71/2092210/84651.72e-039.68e-036.18e-0371
hsa04670ColorectumADLeukocyte transendothelial migration41/2092114/84654.60e-032.20e-021.40e-0241
hsa045201ColorectumADAdherens junction50/209293/84651.52e-092.83e-081.81e-0850
hsa045301ColorectumADTight junction76/2092169/84655.49e-099.69e-086.18e-0876
hsa040151ColorectumADRap1 signaling pathway71/2092210/84651.72e-039.68e-036.18e-0371
hsa046701ColorectumADLeukocyte transendothelial migration41/2092114/84654.60e-032.20e-021.40e-0241
Page: 1 2 3 4 5 6 7 8 9 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
Page: 1 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1